Author(s): Dessy Abdullah, Sandeep Poddar, Nadia Purnama Dewi, Ade Teti Vani

Email(s): dessyabdullah@fk.unbrah.ac.id

DOI: 10.52711/0974-360X.2023.00959   

Address: Dessy Abdullah1,2*, Sandeep Poddar2, Nadia Purnama Dewi1,2, Ade Teti Vani1
1Faculty of Medical, Baiturrahmah University, 49HM+VCJ, Jalan Raya By Pass, AiePacah, Koto Tangah, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586, Indonesia.
2Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor, Malaysia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 12,     Year - 2023


ABSTRACT:
Cholesterol is a chemical that is naturally created by the liver but can also be present in animal-based meals like meat and milk. Cholesterol is required by the body for the formation of healthy cells, the production of several hormones, and the production of vitamin D. Although cholesterol is necessary for the body, high levels can be harmful to one's health, hence therapy to lower cholesterol levels using natural products or the aid of bacterial metabolism is required. Lactobacillus plantarum 2DA is a lactic acid bacterium that has potential as a probiotic, so further analysis is needed on its ability as a therapy to reduce cholesterol through a bioinformatics approach. The method used in this research is to search for bacterial secondary metabolites by studying literature from published journals. Each compound is then searched in the PubChem database for its canonical structure and isomeric SMILE (simplified molecular-input line-entry system) and secondary metabolites in bacteria from the literature study were analyzed for potential using WAY2DRUG PASS prediction (http://www.pharmaexpert. ru/passonline/predict.php) as a cholesterol-lowering treatment. The results of the study based on the prediction of the SAR Way2 Drug Pass Server seen in the Probability To Be Active (Pa) values obtained 0.45, 0.49 and 0.37 for anti-hypercholesterolemic, cholesterol antagonist and cholesterol oxidase inhibitors. From the results obtained, it can be recommended that Lactobacillus plantarum 2DA can be further researched in vivo for cholesterol-lowering therapy.


Cite this article:
Dessy Abdullah, Sandeep Poddar, Nadia Purnama Dewi, Ade Teti Vani. Prediction of Structure Activity Relationship (SAR) of Lactobacillus plantarum DA2 content for Cholesterol Reduction Treatment. Research Journal of Pharmacy and Technology.2023; 16(12):5915-9. doi: 10.52711/0974-360X.2023.00959

Cite(Electronic):
Dessy Abdullah, Sandeep Poddar, Nadia Purnama Dewi, Ade Teti Vani. Prediction of Structure Activity Relationship (SAR) of Lactobacillus plantarum DA2 content for Cholesterol Reduction Treatment. Research Journal of Pharmacy and Technology.2023; 16(12):5915-9. doi: 10.52711/0974-360X.2023.00959   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-12-60


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