Ariadna Anggi Pasang, Alphania Rahniayu, Nila Kurniasari, I Ketut Sudiana, Willy Sandhika, Anny Setijo Rahaju, Dyah Fauziah, Siprianus Ugroseno Yudho Bintoro
Ariadna Anggi Pasang1, Alphania Rahniayu1, Nila Kurniasari1*, I Ketut Sudiana1, Willy Sandhika1, Anny Setijo Rahaju1, Dyah Fauziah1, Siprianus Ugroseno Yudho Bintoro2
1Department of Anatomical Pathology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
2Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Volume - 16,
Issue - 2,
Year - 2023
Diffuse large B-cell lymphoma (DLBCL) is one of the B-cell large cell types of non-Hodgkin lymphoma (NHL) that has poor prognosis with highly variable clinical course. Various prognostic factors have been proposed to predict this, but the results were variable. C-MYC is a proto-oncogen that can cause overexpression leading to the increased of tumor cells proliferation. BAX is a main proapoptotic member of the BCL-2 family proteins that regulates apoptotic function. The study aimed to analyze correlation of c-MYC and BAX protein with various Ann Arbor stages in B-cell large cell type of NHL. This cross-sectional study was performed on 39 formalin fixed paraffin-embedded tissue of patients diagnosed as B-cell large cell type of NHL during January 2017 - December 2019 in Anatomical Pathology Laboratory at Dr. Soetomo General Hospital, Surabaya. To assess the expression of c-MYC and BAX, the immunohistochemistry examination was performed. Immunoexpression of C-MYC and BAX were evaluated according to the number of positive tumor cells divided by the total number of tumor cells and calculated in percentage. There was no difference in C-MYC (p = 0.877) and BAX (p = 0.093) expression with various Ann Arbor stages in B-cell large cell type of NHL. There was no correlation between c-MYC with BAX expression in various Ann Arbor stages in B-cell large cell type of NHL (rs = 0.206, p = 0.209). This indicated that C-MYC and BAX expression alone could not to be used as parameters to predict the outcome of the B-cell large cell type of NHL via Ann Arbor stages.
Cite this article:
Ariadna Anggi Pasang, Alphania Rahniayu, Nila Kurniasari, I Ketut Sudiana, Willy Sandhika, Anny Setijo Rahaju, Dyah Fauziah, Siprianus Ugroseno Yudho Bintoro. Correlation between C-MYC and BAX expression with various Ann Arbor stages in B-cell large cell type of Non-Hodgkin lymphoma. Research Journal of Pharmacy and Technology 2023; 16(2):597-2. doi: 10.52711/0974-360X.2023.00102
Ariadna Anggi Pasang, Alphania Rahniayu, Nila Kurniasari, I Ketut Sudiana, Willy Sandhika, Anny Setijo Rahaju, Dyah Fauziah, Siprianus Ugroseno Yudho Bintoro. Correlation between C-MYC and BAX expression with various Ann Arbor stages in B-cell large cell type of Non-Hodgkin lymphoma. Research Journal of Pharmacy and Technology 2023; 16(2):597-2. doi: 10.52711/0974-360X.2023.00102 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-21
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