Author(s):
M. Sivakumar, V.S. Chandrasekaran, B. Pushpa Kumari
Email(s):
vschandru610@gmail.com
DOI:
10.52711/0974-360X.2023.00106 
Address:
M. Sivakumar1, V.S. Chandrasekaran2*, B. Pushpa Kumari3
1Professor, HOD, Department of Pharmacognosy, Faculty of Pharmacy, Sree Balaji Medical College and Hospital, Bharat Institute of Science and Technology (DU), Chennai.
2Associate Professor, Department of Pharmaceutical Biotechnology, Krishna Teja Pharmacy College, Tirupati 517506.
3Professor, Department of Pharmacology, Krishna Teja Pharmacy College, Tirupati.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2023
ABSTRACT:
Rheumatoid arthritis (RA) is a systemic, chronic inflammatory and auto immune disorder. RA is provoked by genetical predisposition and environmental factors. Oxidative stress makes the human liable to diseases like diabetes, RA, cancer, atherosclerosis etc. Hence the study investigated the anti-arthritic and oxidative activity of ethanolic extract of Glycosmis pentaphylla (EEGP) as it has not been pharmacologically tested. Anti-arthritic potential was evaluated in vitro using protein denaturation by bovine serum albumin and in vivo by Complete Freund Adjuvant (CFA) models at 200 and 400mg/kg doses. Also, in vitro and in vivo antioxidant ability was appraised by DPPH scavenging and assessment of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and lipid peroxidation (LPO). The results exhibited concentration dependent inhibition of albumin denaturation with maximum results obtained at 800µg/ml. The results of CFA model depicted better protection against arthritic lesions and body weight alterations. Also G. pentaphylla remarkably ameliorated histopathological changes. Additionally, plant exhibited remarkable anti-oxidant activity.
Cite this article:
M. Sivakumar, V.S. Chandrasekaran, B. Pushpa Kumari. In vitro and in vivo Anti-arthritic and Antioxidant potential of Glycosmis pentaphylla in Complete Freund’s Adjuvant model. Research Journal of Pharmacy and Technology 2023; 16(2):621-6. doi: 10.52711/0974-360X.2023.00106
Cite(Electronic):
M. Sivakumar, V.S. Chandrasekaran, B. Pushpa Kumari. In vitro and in vivo Anti-arthritic and Antioxidant potential of Glycosmis pentaphylla in Complete Freund’s Adjuvant model. Research Journal of Pharmacy and Technology 2023; 16(2):621-6. doi: 10.52711/0974-360X.2023.00106 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-25
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