Author(s):
Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee
Email(s):
goparoy2020@gmail.com
DOI:
10.52711/0974-360X.2023.00123 
Address:
Gopa Roy Biswas1*, Sayantan Bhattacharya2, Sutapa Biswas Majee2
1Associate Professor in the Department of Pharmaceutics, Guru Nanak Institute of Pharmaceutical Science and Technology,157/F Nilgunj Road, Panihati, Kolkata – 700114.
2Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata - Group of Institutions, Kolkata.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2023
ABSTRACT:
Hydrophilic swellable polymers can be well used for the fabrication of matrix formulations. The present investigation aimed to develop controlled release matrix formulations of Amoxicillin trihydrate with different concentration of gum karaya, without changing the other factors. The matrix granules, prepared by wet granulation process were first evaluated for different micrometrics properties like bulk density, tapped density, Hausner’s ratio, Carr’s index. The drug content and swelling behavior were also investigated in granular form. After that the matrix granules were encapsulated in empty gelatin shell. The encapsulated granules of Amoxycillin trihydrate were subjected to dissolution studies. The drug release data were analyzed to interpret the drug release kinetics. The drug release data was fitted in kinetic models of zero order, first order, Higuchi and Korsmeyer-Peppas equation. For the formulations with higher concentration of gum karaya, the cumulative percent of drug released versus time plot exhibits curvilinear nature, which suggests that drug release is not dominated by zero order kinetics. The results showed that drug release is much more acquainted with Korsmeyer–Peppas and Higuchi models. The granules with 10-15% of gum karaya reveal the dominance of the highly swollen layer which controls the drug release from the matrix granules.
Cite this article:
Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee. Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations. Research Journal of Pharmacy and Technology 2023; 16(2):721-6. doi: 10.52711/0974-360X.2023.00123
Cite(Electronic):
Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee. Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations. Research Journal of Pharmacy and Technology 2023; 16(2):721-6. doi: 10.52711/0974-360X.2023.00123 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-42
REFERENCES:
1. Mandhar P. Joshi G. Development of Sustained Release Drug Delivery System: A Review. Asian Pacific Journal of Health Sciences. 2015; 2(1): 179-185. https://doi.org/10.21276/apjhs.2015.2.1.31
2. Liechty WB. Kryscio DR. Slaughter BV. Peppas NA. Polymers for drug delivery systems. Annual Review of Chemical and Biomolecular Engineering. 2010; 1:149-173. https://doi.org/10.1146/annurev-chembioeng-073009-100847
3. Bhardwaj TR. Kanwar M. Lal R. Gupta A. Natural gums and modified natural gums as sustained-release carriers. Drug Development and Industrial Pharmacy. 2000 Oct;26(10):1025-38. https://doi.org/10.1081/ddc-100100266. PMID: 11028217.
4. Patra JK. Das G. Fraceto LF et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018;16(1):71. doi:10.1186/s12951-018-0392-8
5. Williams PA. Gums: Properties and Uses. In Encyclopedia of Food and Health, Edited by Benjamin Caballero, Paul M. Finglas, Fidel Toldrá, , Academic Press, 2016, pp. 283-289.
6. Kishore Babu M. Subhashini KV. Aruna N. Murthy TEGK. Rheological Studies of Gum Karaya (Sterculia urens) and Gum Kondagogu (Cochlospermum gossypium)): Tree Gums of India. Research J. Pharm. and Tech. 2011;4(5): 775-778. DOI: 10.5958/0974-360X
7. Uppala A. Naga Swapna V. Neelima Devi R. Glory Sheren G. Kishore Kumar B. Research J. Pharm. and Tech. 8(9): Sept, 2015; Page 1269-1275. doi: 10.5958/0974-360X.2015.00230.9
8. Mohammed, MEU, Rahman, EU, Haseeb, MA, Saleem, M, Naveed, A. Formulation and in vitro evaluation of gastro retentive drug delivery systems of amoxicillin trihydrate. Research J. Pharm. and Tech. 2013;6 (10): 1144-1148. DOI: 10.5958/0974-360X
9. Martínez A, Carmona M, Cortés C, and Arauzo I. Characterization of Thermophysical Properties of Phase Change Materials Using Unconventional Experimental Technologies. Energies. 2020; 13(18):4687. https://doi.org/10.3390/en13184687
10. Dhama P. Kumar S. Sagar MK. Development and Characterization of Transdermal patches of Tramadol Hydrochloride: An Approach to Pain Management. Research Journal of Pharmacy and Technology. 2022; 15(1):1-5. doi: 10.52711/0974-360X.2022.00001
11. Mohsen A,, Abousamra MM and Elshebiney S. Enhanced Oral Bioavailability and Sustained Delivery of Glimepiride via Niosomal Encapsulation: In-vitro Characterization and In-vivo Evaluation. Drug Development and Industrial Pharmacy, 2017., 43(8):1-37. https://doi.org/10.1080/03639045.2017.1310224
12. Salve P. Aherrao S. Bali N. Development and Evaluation of Sustained Release Dosage Form using Hydrophilic and Hydrophobic Materials. Research J. Pharm. and Tech. 2016; 9(5): 481-489. https://doi.org/10.5958/0974-360X.2016.00089.5
13. Roy Biswas G. Roy D. Majee SB. Effect Of Cellulosic Polymer On Physico Mechanical Properties Of Superporous Hydrogel Of An Antihypertensive Drug And Drug Release Kinetics From IT. International Journal of Applied Pharmaceutics., 2019., 11(5): 257-263. DOI: http://dx.doi.org/10.22159/ijap.2019v11i5.34734
14. Mukherjee B, S, Gupta R, Patra, B Tiwari A and Arora P. A comparison between povidone ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. European Journal of Pharmaceutics and Biopharmaceutics, 2005., 59 (3), 475-83. DOI: 10.1016/j.ejpb.2004.09.009
15. Patel P. Ahmad U. Akhtar J. Preformulation Studies: An Integral Part of Formulation Design, Pharmaceutical Formulation Design - Recent Practices, Intech Open, 2019; DOI: 10.5772/intechopen.82868.
16. Biswas GR, Majee SB, Roy A. Combination of synthetic and natural polymers in hydrogel: An impact on drug permeation. J App Pharm Sci, 2016; 6 (11): 158-164. DOI: 10.7324/JAPS.2016.601125
17. Kumar Darapu B.N., K. Sundaramoorthy T. Vetrichelvan. Formulation and In-Vitro Evaluation of Gastroretentive Floating Microspheres of Ranitidine Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2011; 3(1): 24-29.
18. Lejcuś K, Spitalnick M, Dąbrowska J. Swelling Behaviour of Superabsorbent Polymers for Soil Amendment under Different Loads. Polymers. 2018; 10(3):271. https://doi.org/10.3390/polym10030271
19. Amballa H., Kaluva N. Beri SGP. Chinnala KM. Konda M. Formulation and Characterization of Eplerenone Mucoadhesive Buccal Tablets. Research Journal of Pharmacy and Technology. 2021; 14(6):3097-3. doi: 10.52711/0974-360X.2021.00541.
20. Bhattacharjee S. Guha N. Dutta G. Chakraborty M. Jana M. Paul S. Formulation and Evaluation of Sustained Release Matrix Tablet of Anti-Amoebic Drug by Natural Polymers. Research J. Pharm. and Tech. 2017; 10(7): 2041-2046. doi: 10.5958/0974-360X.2017.00356.0
21. Khiste R. Bhapkar N. Kulkarni N. A Review on Applications of Hydroxy Propyl Methyl Cellulose and Natural polymers for the development of modified release drug delivery systems. Research J. Pharm. and Tech. 2021; 14(2):1163-1170. doi: 10.5958/0974-360X.2021.00208.0
22. Simancas-Herbada R. Fernández-Carballido A. Aparicio-Blanco J et al. Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets. Pharmaceutics. 2020;12(2):174. doi: 10.3390/pharmaceutics12020174
23. Patil CC. Vekatesh J. Karajgi SR. Vijapure V. Ashwini G. Jorapur PN. Chetan M. Formulation and in vitro Evaluation of Matrix tablets containing Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(8):4429-4. doi: 10.52711/0974-360X.2021.00769
24. Chavhan SA, Shinde SA, Sapkal SB , Shrikhande VN. Herbal Excipients in Novel Drug Delivery Systems. Asian J. Pharm. Res. 2017; 7(2): 111-117. http://dx.doi.org/10.5958/2231-5691.2017.00019.3
25. Reddy KY. Asha Ch. Formulation and Evaluation of Oral Controlled Release Matrix Tablets of Propranolol Hydrochloride. Asian J. Pharm. Res. 2020; 10(2):81-85. DOI: https://doi.org/10.5958/2231-5691.2020.00015.5