Author(s): Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee


DOI: 10.52711/0974-360X.2023.00123   

Address: Gopa Roy Biswas1*, Sayantan Bhattacharya2, Sutapa Biswas Majee2
1Associate Professor in the Department of Pharmaceutics, Guru Nanak Institute of Pharmaceutical Science and Technology,157/F Nilgunj Road, Panihati, Kolkata – 700114.
2Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata - Group of Institutions, Kolkata.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023

Hydrophilic swellable polymers can be well used for the fabrication of matrix formulations. The present investigation aimed to develop controlled release matrix formulations of Amoxicillin trihydrate with different concentration of gum karaya, without changing the other factors. The matrix granules, prepared by wet granulation process were first evaluated for different micrometrics properties like bulk density, tapped density, Hausner’s ratio, Carr’s index. The drug content and swelling behavior were also investigated in granular form. After that the matrix granules were encapsulated in empty gelatin shell. The encapsulated granules of Amoxycillin trihydrate were subjected to dissolution studies. The drug release data were analyzed to interpret the drug release kinetics. The drug release data was fitted in kinetic models of zero order, first order, Higuchi and Korsmeyer-Peppas equation. For the formulations with higher concentration of gum karaya, the cumulative percent of drug released versus time plot exhibits curvilinear nature, which suggests that drug release is not dominated by zero order kinetics. The results showed that drug release is much more acquainted with Korsmeyer–Peppas and Higuchi models. The granules with 10-15% of gum karaya reveal the dominance of the highly swollen layer which controls the drug release from the matrix granules.

Cite this article:
Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee. Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations. Research Journal of Pharmacy and Technology 2023; 16(2):721-6. doi: 10.52711/0974-360X.2023.00123

Gopa Roy Biswas, Sayantan Bhattacharya, Sutapa Biswas Majee. Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations. Research Journal of Pharmacy and Technology 2023; 16(2):721-6. doi: 10.52711/0974-360X.2023.00123   Available on:

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