Author(s):
Basaria Manurung, Hadyanto Lim, Jekson Martiar Siahaan, Endy Juli Anto, Putri C Eyanoer, Sandeep Poddar
Email(s):
basariamanurung31@gmail.com
DOI:
10.52711/0974-360X.2023.00138 
Address:
Basaria Manurung1, Hadyanto Lim2, Jekson Martiar Siahaan2, Endy Juli Anto3, Putri C Eyanoer4, Sandeep Poddar5
1Student of Masters Program in Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Jl. Hang Tuah No.8, Madras Hulu, Kec. Medan Polonia, Kota Medan, Sumatera Utara 20151, Indonesia.
2Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Jl. Hang Tuah No.8, Madras Hulu, Kec. Medan Polonia, Kota Medan, Sumatera Utara 20151, Indonesia.
3Department of Immunology, Faculty of Medicine, Universitas Methodist Indonesia, Jl. Hang Tuah No.8, Madras Hulu, Kec. Medan Polonia, Kota Medan, Sumatera Utara 20151, Indonesia.
4Department of Community and Preventive Medicine, Faculty of Medicine, Uiversitas Sumatera Utara, Jalan Dr. T. Mansur No.9, Padang Bulan, Kec. Medan Baru, Kota Medan, Sumatera Utara 20222, Indonesia.
5Deputy Vice Chancellor (Research & Innovation) Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301
Published In:
Volume - 16,
Issue - 2,
Year - 2023
ABSTRACT:
Gestational Diabetes Mellitus is a disorder of carbohydrate tolerance that results in increased blood sugar levels and was first recognised during the second and third trimesters of pregnancy. It is a health problem that has a direct impact on the health of the mother and fetus. The purpose of this study was to analyse the effect of jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on reducing Blood Sugar Levels and Inflammation in Wistar Albino Rats with Gestational Diabetes Mellitus induced by Streptozotocin. This study used a laboratory experimental research design with a post-test only control group design on Wistar Albino Rats with Gestational Diabetes Mellitus. The sample was obtained by the simple random sampling method. The results showed that the lowest spectrophotometer KGD level was in group C given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.003, which means there was a significant difference between groups and the lowest Interleukin-6 level. In group C, they were given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.511, meaning there was no significant difference between groups. Jackfruit seed ethanol extract functions as a lowering of blood sugar levels and an anti-inflammatory.
Cite this article:
Basaria Manurung, Hadyanto Lim, Jekson Martiar Siahaan, Endy Juli Anto, Putri C Eyanoer, Sandeep Poddar. The Effect of Jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on Blood Sugar Levels and Anti-Inflammatory Reduction on Wistar Albino Rats Streptozotocin-Induced Gestational Diabetes. Research Journal of Pharmacy and Technology 2023; 16(2):804-8. doi: 10.52711/0974-360X.2023.00138
Cite(Electronic):
Basaria Manurung, Hadyanto Lim, Jekson Martiar Siahaan, Endy Juli Anto, Putri C Eyanoer, Sandeep Poddar. The Effect of Jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on Blood Sugar Levels and Anti-Inflammatory Reduction on Wistar Albino Rats Streptozotocin-Induced Gestational Diabetes. Research Journal of Pharmacy and Technology 2023; 16(2):804-8. doi: 10.52711/0974-360X.2023.00138 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-57
REFERENCES:
1. Departemen kesehatan republik indonesia, “Perlunya deteksi dini untuk cegah dan kurangi risiko diabete,” Perlunya deteksi dini untuk cegah dan kurangi risiko diabetes, 2016, [Online]. Available: www.depkes.go.id.
2. Lakshmi. K. Effectiveness of Nursing care of antenatal mothers with Gestational diabetes mellitus. Asian J. Nursing Education and Research. 2020; 10(3): 286-290. https://doi.org/10.5958/2349-2996.2020.00060.9
3. Sachin B. Somwanshi, Punam D. Bairagi, Kiran B. Kotade. Study of Gestational Diabetes Mellitus: A Brief Review. Asian J. Pharm. Res. 2017; 7(2): 118-123. https://doi.org/10.5958/2231-5691.2017.00020.X
4. Arul Mozhi. D, Vijaya Manickam. R, Mangala Gowri. Gestational Diabetes Mellitus –Prevention by Life Style Modification. Int. J. Adv. Nur. Management 2(3): July-Sept., 2014; Page 177-179.
5. Smitha K.R, Sandhya D’Almeida. Effectiveness of Self-Instructional Module on Knowledge Regarding Self-Care Management of Gestational Diabetes Mellitus among Antenatal Women Visiting Selected Antenatal Clinic at Mangalore”. Int. J. Adv. Nur. Management 3(1):Jan. - Mar., 2015; Page 42-45.
6. Marie Rosy, Litty Stanley. Evaluate The Effect of Post Prandial Exercise on Blood Sugar Level of Antenatal Mothers with Gestational Diabetes Mellitus at Women and Children‘s Hospital, Alappuzha. Int. J. Nur. Edu. and Research 2(4): Oct.- Dec. 2014; Page 350-355.
7. Sumanpreet Kaur, Harmanpreet Kaur. A Descriptive Study to Assess the Knowledge Regarding Diabetes Mellitus among the Residents of Selected Rural Community, Gurdaspur, Punjab. Int. J. Nur. Edu. and Research. 2017; 5(1): 19-26.
8. P. Maheshwari, T.S. Shanmugarajan. Gestational Diabetes mellitus effects on Macrosomia and risk of Developing Type 2 Diabetes in Tertiary care hospital. Research J. Pharm. and Tech. 2017; 10(6): 1589-1991. https://doi.org/10.5958/0974-360X.2017.00279.7
9. Maheshwari. P, Guna. B, Ranjith Kumar M, Renugadevi. S. Drug Utilization and Evaluation of Gestational Diabetes Mellitus. Research J. Pharm. and Tech 2017; 10(12): 4206-4208. https://doi.org/10.5958/0974-360X.2017.00768.5
10. Tandi J, Claresta JA, Ayu G, Irwan I. Effect of ethanol extract of kenikir (Cosmos caudatus Kunth.) leaves in blood glucose, cholesterol and histopathology pancreas of male white rats (Rattus norvegicus). Indonesian Journal of Pharmaceutical Science and Technology. 2018 Jun 28;1(1):70-8.
11. Hardyanti, S. 2019. Gambaran Kejadian Diabetes Melitus Gestasional (DMG) Di Kabupaten Sleman Kota Yogyakarta Tahun 2018 [skripsi]. Yogyakarta: Program Studi Kebidanan Program Sarjana Terapan Fakultas Ilmu Kesehatan Universitas ‘Aisyiyah Yogyakarta.
12. Sulistiyah S, Ismiatun L, Ernawati N, Shella S. Faktor Pendukung Timbulnya Resiko Gestasional Diabetes Mellitus Pada Ibu Hamil di BPS Kabupaten Malang. Jurnal Kesehatan Hesti Wira Sakti. 2017 Apr 15; 5(2):108-15.
13. Rahmawati F, Natosba J, Jaji J. Skrining diabetes mellitus gestasional dan faktor risiko yang mempengaruhinya. Jurnal Keperawatan Sriwijaya. 2016 Jan 22; 3(2):33-43.
14. RAHAYU VA, Herlina H, Solihah I. Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Kenikir (Cosmos Caudatus Hbk) Terhadap Tikus Jantan Galur Wistar Yang Diinduksi Aloksan (Doctoral dissertation, Sriwijaya University).2018
15. Rahayu A, Rodiani R. Efek Diabetes Melitus Gestasional terhadap Kelahiran Bayi Makrosomia. Medical Journal of Lampung University [MAJORITY]. 2016 Nov 1; 5(4):17-22.
16. Kurniawan MB, Wiwin NW. Hubungan Antara Diabetes Melitus Gestasional Dan Berat Badan Lahir Dengan Kejadian Respiratory Distress Syndrome (RDS) Pada Neonatus di RSUD Abdul Wahab Sjahranie Samarinda. Borneo Student Research (BSR). 2020 Aug 4; 1(3):1805-12.
17. Introduction: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018 Jan;41(Suppl 1):S1-S2. doi: 10.2337/dc18-Sint01.
18. Candra S, Widodo S A. Pengaruh pemberian ekstrak buah belimbing wuluh (Averrhoa blimbi L.) terhadap penurunan kadar glukosa darah tikus wistar yang diinduksi aloksan (Doctoral dissertation, Fakultas Kedokteran).2012
19. Dwitiyanti M, Efendi K, Rachmania RA, Septiani R. Aktivitas Ekstrak Etanol 70% Biji Nangka (Artocarpus heterophyllus Lam.) dalam Penurunan Kadar Gula Darah Tikus Diabetes Gestasional yang Diindukasi Streptozotocin. Jurnal Jamu Indonesia. 2019;4(1):1-7. doi: 10.29244/jji.v4i1.84.
20. Siahaan JM. Pengaruh Ekstrak Buah Labu Siam (Sechium edule Jacq. Swartz.) Terhadap Stress Oksidatif dan Resistensi Insulin pada Tikus Putih Jantan Galur Wistar Model Diabetes Mellitus Tipe 2.2020
21. Sutrisna EM, Tanti Azizah S, Lutfiana Dewi I. Antidiabetic activity of ethanolic extract of Eugenia polyantha wight leaf from indonesia in diabetic rat wistar strain induced by alloxan. Asian Journal of Pharmaceutical and Clinical Research. 2016; 9(1):374-76.
22. Purnamasari E, Poerwantoro B. Diabetes Mellitus dengan Penyulit Kronis. Majalah Kesehatan PharmaMedika. 2011; 3(2):276-81.
23. Siahaan JM, Illyas S, Lindarto D, Nainggolan M. The effect of ethanol and ethyl acetate fraction of chayote fruit (Sechium edule jacq. swartz) on the oxidative stress and insulin resistance of male white rat model type 2 diabetes mellitus. Open Access Macedonian Journal of Medical Sciences. 2020 Dec 15; 8(A):962-9. https://doi.org/10.3889/OAMJMS.2020.4517
24. Santosoa J, Ratnaningsihb D. Pengembangan Makanan Tape dengan Bahan Dasar dari Biji Buah Nangka (Beton)(Artocarpus heterophyllus Lam.) yang Dikombinasikan dengan Daun Kelor (Moringa Oleifera Lam.) sebagai Obat Antidiabetes Development of Food “Tape” with Basic Material from Jackfruit Seeds (Concrete)(Artocarpus heterophyllus Lam.) Combined with Moringa Oleifera.2019
25. Margono RS, Sumiati T. Potensi Tanaman Indonesia sebagai Antidiabetes melalui Mekanisme Penghambatan Enzim α-glukosidase. Jurnal Farmamedika (Pharmamedika Journal). 2019 Dec 12; 4(2):86-92. doi: 10.47219/ath.v4i2.84.
26. Dwitiyanti D, Rachmania A, Efendi K, Atmojo TT. Potensi Biji Buah Nangka (Artocarpus Heterophyllus L.) Dalam Menghambat Reseptor Alfa-Glukosidase Pada Tikus Diabetes Mellitus Gestasional Yang Terinduksi Streptozotosin Secara In Vivo Dan In Silico. InProsiding Seminar Nasional Berseri 2018 (pp. 118-130).
27. Hasim H, Arifin YY, Andrianto D, Faridah DN. Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi) sebagai Antioksidan dan Antiinflamasi. Jurnal Aplikasi Teknologi Pangan. 2019 Aug 12; 8(3):86-93. doi: 10.17728/jatp.4201
28. Bose D. Potentials of Cuminum cyminum in Microbial Control. International Journal of Advancement in Life Sciences Research. 2018 May 1:8-12. https://doi.org/10.31632/ijalsr.2021.v04i03.004