Author(s): Santhosh S, Pazhani GP, Arathi MS, Manickam S


DOI: 10.52711/0974-360X.2023.00161   

Address: Santhosh S1, Pazhani GP2, Arathi MS3, Manickam S4*
1Scholar, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
2Associate Professor, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulattur – 603203, Tamil Nadu, India.
3Associate Professor, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
4 Associate Professor, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023

The herb Boerhavia diffusa (BD) is well-known in the Indian medicinal system. Punarnava is its vernacular name. BD is one of the chief ingredients in ayurvedic formulations used for urinary diseases. In the realm of phytochemistry, the plant has risen to prominence due to its diverse biological activities. Here, we reviewed the scientific literature available on administration of BD for acute kidney injury, chronic kidney disease, polycystic kidney disease, renal calculi, urinary tract infection, and COVID-19 related kidney disease and we also explored its antioxidant and anti-inflammatory properties. The nephroprotective effect of BD has been clearly demonstrated in in vitro, in vivo, and in clinical studies. The in vivo studies have yielded a plethora of data. The most commonly employed extracts were aqueous, hydroalcoholic, ethanolic, and methanolic extracts. Clinical studies have employed polyherbal combinations containing BD extract. Irrespective of the type of BD extract, all studies showed reduction in the key markers of kidney diseases, namely urea, creatinine, BUN, and proteins. It has antifibrotic property reducing the formation of extracelluar collagen deposition in the renal tubules, which is not much explored. The review highlights the importance of further research required in establishing the molecular mechanisms underlying the action of BD. With in-depth molecular research and clinical trials, BD could be developed into a novel therapeutic agent for the successful treatment of renal disorders especially the chronic kidney disease.

Cite this article:
Santhosh S, Pazhani GP, Arathi MS, Manickam S. Nephroprotective Role of Boerhavia diffusa in Renal Disorders: A Review. Research Journal of Pharmacy and Technology 2023; 16(2):962-8. doi: 10.52711/0974-360X.2023.00161

Santhosh S, Pazhani GP, Arathi MS, Manickam S. Nephroprotective Role of Boerhavia diffusa in Renal Disorders: A Review. Research Journal of Pharmacy and Technology 2023; 16(2):962-8. doi: 10.52711/0974-360X.2023.00161   Available on:

1.    Nayak P.Thirunavoukkarasu M. A review of the plant Boerhaavia diffusa: Its chemistry, pharmacology and therapeutical potential. The Journal of Phytopharmacology. 2016;5(2):83-92.
2.    Sharma R. Kumari N. Ashawat M.Verma C. Standardization and phytochemical screening analysis for herbal extracts: Zingiber officinalis, Rosc., Curcuma longa Linn., Cinnamonum zeylanicum Nees., Piper longum, Linn., Boerhaavia diffussa Linn. Asian J. Pharm. Tech. 2020;10(3):127-133.
3.    Jayachitra J. Janani B. Bharathi V. Manikandan R. Phytochemical analysis and mineral composition of Methanolic extract of Boerhavia diffusa L. Research J. Pharm. and Tech. 2020;13(10):4856-4860.  
4.    Mishra S. Aeri V. Gaur PK. Jachak SM. Phytochemical, therapeutic, and ethnopharmacological overview for a traditionally important herb: Boerhavia diffusa Linn. Biomed Res. Int. 2014;2014:808302.
5.    Pradhan D. Das C. Das D. Kar DM. Ghosh G. Isolation of major Phytoconstituents and Standardization of different extracts of Boerhavia diffusa by RP-HPLC. Research J. Pharm. and Tech. 2020;13(1):297-302.
6.    Ferreres F. Sousa C. Justin M. Valentão P. Andrade PB. Llorach R, et al. Characterisation of the phenolic profile of Boerhaavia diffusa L. by HPLC-PAD-MS/MS as a tool for quality control. Phytochemical analysis : PCA. 2005;16(6):451-458.
7.    Peesa JP. Nephroprotective potential of herbal medicines: A review. Asian J. Pharm. Tech. 2013;3(3):115-118.
8.    Kalaivani M. Arockiasamy S. John C. Vasanthi HR. Soundararajan P. Therapeutic potential of Boerhavia diffusa L. against cyclosporine A-Induced mitochondrial dysfunction and apoptosis in madin–Darby canine kidney cells. Pharmacognosy Magazine. 2018;14(55):132-140.
9.    Vineeth TV. Deepak M. Shree ABR.Vaidya A. Antibacterial effect of Boerhavia Diffusa and Punarnavasavam on urinary tract infection (UTI) causing pathogens. World Journal of Pharmaceutical Research. 2014;3(5):423-437.
10.    Dachuri V. Song PH. Kim YW. Ku SK.Song CH. Protective Effects of Traditional Polyherbs on Cisplatin-Induced Acute Kidney Injury Cell Model by Inhibiting Oxidative Stress and MAPK Signaling Pathway. Molecules (Basel, Switzerland). 2020;25(23):5641.
11.    Bhusan SH. Kumar AA. Ashish TF. Lal KM. Evaluation of Polyherbal formulation for Diuretic activity in albino rats. Asian Pacific Journal of Tropical Disease. 2012;2:S442-S445.
12.    Venkatesh P. Dinakar A.Senthilkumar N. Evaluation of diuretic activity of an alcoholic extracts of Boerhaavia diffusa and Anisochilus carnosus in rats. Int. J. Drug. Dev. Res. 2012;4:239-242.
13.    Sawardekar SB. Patel TC. Evaluation of the effect of Boerhavia diffusa on gentamicin-induced nephrotoxicity in rats. Journal of Ayurveda and integrative medicine. 2015;6(2):95-103.
14.    Oburai NL. Rao VV. Bonath RB. Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure. Journal of Ayurveda and integrative medicine. 2015;6(3):150-157.
15.    Raval SK. Patel SG. Dhami AJ. Bhavsar SK. Prophylactic Effect of Biherbal Extracts of Boerhavia diffusa and Tribulus terrestris in Wistar Rats against Adenine Induced Chronic Kidney Disease: Haemato-Biochemical Profile. The Indian Journal of Veterinary Sciences and Biotechnology. 2020;16(2,3 & 4):58-61.
16.    Pareta SK. Harwansh RK. Kumar M. Prasad KK. Protective Effects of Boerhaavia Diffusa Against Acetaminophen Induced Nephrotoxicity in Rats. Pharmacologyonline. 2011;2:698-706.
17.    Karwasra R. Kalra P. Nag TC. Gupta YK. Singh S. Panwar A. Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa. Regulatory toxicology and pharmacology : RTP. 2016;81:341-352.
18.    Arivu I. Muthulingam M. Hypolipidemic efficacy of Boerhaavia diffusa (Linn.) In kidney on D- Galactosamine induced fatty liver in male albino wistar rats. Int. J. Modn. Res. Revs. 2015;3(7):721-725.
19.    Vaidegi N. Anuradha R. Antinephrotoxic Effect of Boerhaavia diffusa L. Root on Lead Acetate Induced Nephrotoxicity in Male Albino Rats. Research J. Pharmacology and Pharmacodynamics. 2012;4(6):353-356. 2321-5836
20.    Indhumathi T. Shilpa K. Mohandass S. Evaluation of Nephroprotective role of Boerhaavia diffusa leaves against mercuric chloride induced toxicity in experimental rats. J. Pharm. Res. 2011;4(6):1848-1850.
21.    Barwal A. Kumari S. Verma SK. Goyal P. Sharma I. Sharma S, et al. Evaluation of herbal formulation Neeri (NS-RF) for protective effects against heavy metal induced nephrotoxicity in rats. Indo American Journal of Pharmaceutical Research. 2015;5:2790-2798.
22.    Sharma S. Baboota S. Amin S. Mir SR. Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat. Pharmaceutical biology. 2020;58(1):184-199.
23.    Ahmad A. Abuzinadah M. Alkreathy H. Kutbi H. Shaik N. Ahmad V, et al. A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model. Asian Pacific Journal of Tropical Biomedicine. 2020;10(4):147-155.
24.    Bodakhe KS. Namdeo KP. Patra KC. Machwal L.Pareta SK. A polyherbal formulation attenuates hyperoxaluria-induced oxidative stress and prevents subsequent deposition of calcium oxalate crystals and renal cell injury in rat kidneys. Chinese journal of natural medicines. 2013;11(5):466-471.
25.    Pareta SK. Patra KC. Mazumder PM. Sasmal D. Aqueous extract of Boerhaavia diffusa root ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney. Pharmaceutical biology. 2011;49(12):1224-1233.
26.    Yadav D. Sharma A. Srivastava S.Tripathi YB. Nephroprotective potential of standardized herbals described in Ayurveda: a comparative study. J. Chem. Pharm. Res. 2016;8:419-427.
27.    Maurya H. Kumar T. Antinephrotic potential of CATCAB-50 in CCL4 induced glomerulonephritic animal. Int. J. Pharm. Med. Res. 2016;4(2):324-328.
28.    Shanmugapriya S. Anuradha R. Kiruthika R. Venkatalakshmi P. Velavan S. Formulation and evaluation of Abutilon indicum and Boerhaavia diffusa for the determination of nephroprotective activities. J. Sci. Trans. Environ. Technov. 2015;9(2):101-106.
29.    Nalini G. Chidambaranathan N. Jegan N. Santhana Kumar M. Marimuthu K. Effect of Hydroalcoholic Extract of Boerhaavia Diffusa Linn against Cisplatin Induced Nephrotoxicity. IOSR Journal of Pharmacy and Biological Sciences. 2015;10(4):17-22.
30.    Singh PK. Baxi D. Doshi A. Ramachandran AV. Antihyperglycaemic and renoprotective effect of Boerhaavia diffusa L. in experimental diabetic rats. Journal of complementary and integrative medicine. 2011;8.
31.    Pareta SK. Patra KC. Mazumder PM. Sasmal D. Prophylactic role of Boerhaavia diffusa in ethylene glycol induced calcium oxalate urolithiasis. African Journal of Urology. 2011;17(2):28.
32.    Vaishnav R. Patel S. Patel N. Evaluation of safety and anti-urolithiatic property of various polyherbal formulations using ethylene glycol-ammonium chloride and potassium oxonate induced urolithiasis in rats and mice respectively. Journal of Drug Delivery and Therapeutics. 2017;7(7):208-210.
33.    Sathyapriya K. Vijayachandrika V. Parameswari C. Antioxidant status in polycystic end-staged renal diseased patients and antihemolytic effect of Boerhaavia diffusa. Indian Journal of Biochemistry and Biophysics. 2009;46:269-272.
34.    Dwivedi D. Mishra PK. Pandey AK. Management Of chronic kidney disease through Ayurveda: A case study. World Journal of Pharmacy and Pharmaceutical Sciences. 2016;6(2):1318-1325.
35.    Misar S. Management of Renal Parenchymal Disease in Ayurveda-A Case Study. International Journal of Science and Research. 2017;6(2):492-495.
36.    Patel M. Patel M. Patel K. Wischnewsky M. Stapelfeldt E. Kessler CS, et al. Deceleration of Disease Progress Through Ayurvedic Treatment in Nondialysis Stages IV–V Patients with Chronic Renal Failure: A Quasi-Experimental Clinical Pilot Study with One Group Pre-and Postdesign and Two Premeasurements. J. Altern. Complement. Med. 2020;26(5):384-391.
37.    Nayak S. Nayak S. Prasad Dash D. Das B. A clinical study on the effect of Boerhaavia diffusa (Punarnava) in essential hypertension. Ayushdhara. 2015;2(6):390-396.
38.    Hagone PA. Kuchewar V. Management of glomerulonephritis through Ayurveda-a case report. International Journal of Ayurvedic Medicine. 2019;10(4):345-347.
39.    Sekhar MS. Anindya B. Boerhavia diffusa L. may have promising potential to alleviate hyperkalemia. International Journal of Applied Ayurved Research.1(10):39-45.
40.    Deshpande S. Malekar S. Asghar S. Showkat P. Pragati U. A Case Report of Urolithiasis of Patient with Multiple Bilateral Renal Stones. International Journal of Scientific and Research Publications. 2013;3(6):1-4.
41.    Derouiche S. Cheradid T. Guessoum M. Heavy metals, oxidative stress and inflammation in pathophysiology of chronic kidney disease- A review. Asian J.Pharm. Tech. 2020;10(3):202-206.
42.    Rafiq M. Viswanatha G. Mohammed Azeemuddin M. Suryakanth D. Uday Kumar V.Patki P. Cystone, a well-known herbal formulation improves renal function in rats with acute renal failure (ARF) induced by Glycerol intoxication. Iranian Journal of Pharmacology and Therapeutics. 2012;11(2):40-44.
43.    Zalavadiya V. Shah V. Santani D. A Review on Urolithiasis and its Treatment using Plants. Research J. Pharmacognosy and Phytochemistry. 2013;5(1):1-8.
44.    Suman. Herbs: An alternative approach in Nephroprotection. Research J. Pharmacognosy and Phytochemistry. 2013;5(1):15-21.
45.    Dhole AR. Dhole VR. Magdum CS. Mohite S. Herbal therapy for urolithiasis: A brief review. Research J. Pharmacology and Pharmacodynamics. 2013;5(1):6-12. 2321-5836
46.    Kumar KS. Saideepthi V. Shahajeb S. Nandini M. Suthakaran R. Evaluation of analgesic potential of Boerhavia diffusa roots in albino mice. Research J. Pharmacognosy and Phytochemistry. 2017;9(2):111-114.
47.    Han X. Ye Q. Kidney involvement in COVID-19 and its treatments. J. Med. Virol. 2021;93(3):1387-1395.
48.    Rutwick Surya U. Praveen N. A molecular docking study of SARS-CoV-2 main protease against phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug discovery. Virusdisease. 2021;32(1):1-9.
49.    Badmanaban R. Milan GP. Patel CN. Sen DJ. Bibhuranjan P. Studies on Leaf extracts of drug Punarnava by comparing its Antioxidant potential by Spectrophotometric method. Research J. Pharm. and Tech. 2010;3(2):566-569.

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