Author(s): Jyotsna Pandit Khedkar, Sreemoy Kanti Das, Prashant Suresh Salunke, Sandeep Poddar

Email(s): bkjyotsna108@gmail.com

DOI: 10.52711/0974-360X.2023.00189   

Address: Jyotsna Pandit Khedkar1*, Sreemoy Kanti Das1, Prashant Suresh Salunke1, Sandeep Poddar2
1Faculty of Pharmacy, Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor D. E., Malaysia.
2Deputy Vice Chancellor (Research & Innovation), Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor D. E., Malaysia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2023


ABSTRACT:
Background: The purpose of this study is to determine how amiodarone, an antiarrhythmic medication, affects Glibenclamide's hypoglycemic activity in normal and diabetic rats when administered in multiple doses over seven days. Methods: The researchers intended to explore how glibenclamide and amiodarone pharmacologically interact in normal and diabetic rats. These tests were performed on the same group of rats after the provided medications Glibenclamide 1.03 mg/kg body weight and Amiodarone 50 mg/kg body weight had been entirely eliminated, i.e. after the drugs had been totally eliminated. The drugs were administered orally. After taking blood samples from the tail vein at predetermined intervals, the glucose levels were estimated using the GOD/POD technique. Results:The findings showed that numerous doses of amiodarone, an antiarrhythmic medication, affected the hypoglycaemic action of Glibenclamide in normal and diabetic rats when provided alone and in combination with Glibenclamide. This might be because amiodarone and Glibenclamide have a pharmacokinetic interaction. Conclusion: Preliminary research suggests that the combination has a pharmacokinetic interaction in diabetic patients with arrhythmia. As a result, blood glucose levels needed to be closely monitored.


Cite this article:
Jyotsna Pandit Khedkar, Sreemoy Kanti Das, Prashant Suresh Salunke, Sandeep Poddar. Amiodarone’s effect on the Pharmacokinetics of Glibenclamide in Healthy and Diabetic Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1134-8. doi: 10.52711/0974-360X.2023.00189

Cite(Electronic):
Jyotsna Pandit Khedkar, Sreemoy Kanti Das, Prashant Suresh Salunke, Sandeep Poddar. Amiodarone’s effect on the Pharmacokinetics of Glibenclamide in Healthy and Diabetic Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1134-8. doi: 10.52711/0974-360X.2023.00189   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-3-25


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