Mythili Srinivasan, Deshmukh Apurva, Wani Manish, Polshettiwar Satish, Pande Varun, Deshpande Maitreyee, Pandit Ashlesha, Tagalpallewar Amol, Baheti Akshay
Mythili Srinivasan1, Deshmukh Apurva2, Wani Manish1, Polshettiwar Satish1, Pande Varun1, Deshpande Maitreyee2, Pandit Ashlesha3, Tagalpallewar Amol1, Baheti Akshay1*
1School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, India.
2MAEERs Maharashtra Institute of Pharmacy, Pune, Maharashtra, India.
3JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune.
Volume - 16,
Issue - 3,
Year - 2023
The aim of the current research was to formulate and evaluate herbal extracts tooth gel of of Emblica officinalis, Terminalia bellirica, Terminalia chebula, Trachycpermum ammi, Embelia ribes and Syzygium aromaticum, which are used for oral hygiene, plaque control, gingivitis, anti-bacterial, astringent and prevent tooth decay. Powders were extracted separately and further evaluated for phytochemical screening which showed presence of phytoconstituents like alkaloids, tannins, flavonoids and carbohydrates. A 23 factorial design was used to optimize tooth gel using independent variables: concentration of sodium carboxymethyl cellulose (X1) (2 and 3 %); concentration of Gantrex (X2) (0 and 1%) and concentration of sodium lauryl sulphate (X3) (1.5 and 2.5 %) and dependent variables foaming capacity (Y1) and zone of inhibition (Y2). Tooth gel was evaluated for color, odor, taste and pH. Gel exhibited good viscosity, extrudability, spreadability and antimicrobial activity. Formulation F5 showed highest foamability (48.2±0.4ml) and zone of inhibition (4.4±0.2cm) with the desirability value 1 (most desirable response) at design space X1 = 2%, X2 = 0%, X3 = 2.5 % and was therefore considered optimize formulation. Formulation was found stable after 3 months of stability studies. Thus, formulated toothgel had better results when compared with marketed formulation. In conclusion, formulated toothgel was considered as helpful to take care of oral hygiene of human being.
Cite this article:
Mythili Srinivasan, Deshmukh Apurva, Wani Manish, Polshettiwar Satish, Pande Varun, Deshpande Maitreyee, Pandit Ashlesha, Tagalpallewar Amol, Baheti Akshay. Development and In-vitro Effectiveness of Tooth-gel containing Herbal Extracts. Research Journal of Pharmacy and Technology 2023; 16(3):1283-8. doi: 10.52711/0974-360X.2023.00211
Mythili Srinivasan, Deshmukh Apurva, Wani Manish, Polshettiwar Satish, Pande Varun, Deshpande Maitreyee, Pandit Ashlesha, Tagalpallewar Amol, Baheti Akshay. Development and In-vitro Effectiveness of Tooth-gel containing Herbal Extracts. Research Journal of Pharmacy and Technology 2023; 16(3):1283-8. doi: 10.52711/0974-360X.2023.00211 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-3-47
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