Author(s):
Jeslyne M. Jeyaraj, Senthilnathan Balaraman, Vigneshwar Murugesan, Balaji Pandiyan, Umakrithika Selvaraj, Anitha Kandhasamy
Email(s):
umakrithikamails@gmail.com
DOI:
10.52711/0974-360X.2023.00233 
Address:
Jeslyne M. Jeyaraj1, Senthilnathan Balaraman2, Vigneshwar Murugesan3, Balaji Pandiyan4, Umakrithika Selvaraj5*, Anitha Kandhasamy6
1Bharath Institute of Higher Education and Research, Selaiyur, Chennai, Tamilnadu, India.
2GRT Institute of Pharmaceutical Education and Research, Thiruthani, Tamilnadu, India.
3Faculty of Pharmacy, Dr. MGR Educational and Research Institute, Chennai, Tamilnadu, India.
4Department of Pharmacoloy, School of paharmaceutical Sciences, Vels Institute of Science, Technology and Advanced studies (VISTAS), Pallavaram, Chennai-600117. Tamilnadu, India.
5GITAM School of Pharmacy, GITAM (Deemed to be) University, Hyderabad, Telangana, India.
6Department of Chemistry, Arulmigu Palaniandavar Arts College for Women, Palani, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2023
ABSTRACT:
In today’s modern world the chemical induced hepatotoxicity is one huge threat to human life, even the drugs which have easy accessibility and availability are also produces side effects, when they are used irrationally, so the need for antidote from herbal industry is a common factor. Bauhinia tomentosa Linn belongs to fabaceae, considered as one such potential agent which constitutes wide range of chemical compounds which has therapeutic as well as antidote effect. In this study Bahuinia tomentosa Linn was extracted with ethyl alcohol and the prepared ethanolic extract was evaluated for its hepato protective effect against Acetaminophen induced hepato toxicity in albino mice. The biochemical estimation, histo pathological studies are served as index for the assessment of hepatoprotective activity. Modification in body and liver weight, proteins, levels of biomarkers, antioxidant enzymes along with histopatological variations of extract treated groups were compared with standard hepatoprotective drug silymarin. Marked hepatoprotective activity was noticed in extract treated groups in dose dependent manner. The study results revealed the antihepatato toxic effect of Bauhinia tomentosa Linn and recommended as an excellent natural source of drug in the treatment of acetaminophen induced hepatotoxicity.
Cite this article:
Jeslyne M. Jeyaraj, Senthilnathan Balaraman, Vigneshwar Murugesan, Balaji Pandiyan, Umakrithika Selvaraj, Anitha Kandhasamy. Assessment of Anti-Hepatotoxic Effect of Bahuinia tomentosa Linn against Paracetamol induced Hepatocellular Damage In Albino Mice. Research Journal of Pharmacy and Technology 2023; 16(3):1415-0. doi: 10.52711/0974-360X.2023.00233
Cite(Electronic):
Jeslyne M. Jeyaraj, Senthilnathan Balaraman, Vigneshwar Murugesan, Balaji Pandiyan, Umakrithika Selvaraj, Anitha Kandhasamy. Assessment of Anti-Hepatotoxic Effect of Bahuinia tomentosa Linn against Paracetamol induced Hepatocellular Damage In Albino Mice. Research Journal of Pharmacy and Technology 2023; 16(3):1415-0. doi: 10.52711/0974-360X.2023.00233 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-3-69
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