Anand Koppal, Vagdevi H. R, Senthilkumar Sivanesan, Sukumar Ethirajan, Rajagopalan Vijayaraghavan
Anand Koppal1, Vagdevi H. R2, Senthilkumar Sivanesan3, Sukumar Ethirajan4, Rajagopalan Vijayaraghavan5
1Assistant Professor, Department of Pharmacology, PES Institute of Medical Sciences and Research Kuppam - 517425 Andhra Pradesh, India.
2Associate Professor, Bapuji College of Allied Health Sciences, Shivamogga - 577222 Karnataka, India.
3Associate Professor, Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, Tamilnadu, India.
4Advisor, Research and Development ,Vpro Biotech Division Arumparthapuram Main Road Puducherry - 605110, India.
5Research Director, Department of Research and Development, Saveetha Institute of Medical and Technical Sciences Chennai - 602105, Tamilnadu, India.
Volume - 16,
Issue - 5,
Year - 2023
Objective: The present work evaluated the therapeutic potential of embelin monotherapy, embelin plus levodopa (L-Dopa) combination therapy in rotenone induced Parkinson’s disease (PD) model mice. Scope: Based on several growing evidence, antioxidants can be considered as modifiable factors that eventually decrease the risk of degeneration and progression of PD. Especially anti-oxidants from herbal medicines play vital role against several degenerative diseases. Therefore, we evaluated the neuroprotective effect of embelin and embelin plus L-Dopa therapy in rotenone induced behavioural changes in mice. Methods: Swiss Albino male adult mice were randomly divided into 7 groups. Group-1 (Control) 2mL/kg olive oil by oral route (p.o.), Groups from 2 to 7 were induced with 2.5mg/kg rotenone by intraperitoneal route (i.p.), L-Dopa 7.5mg/kg p.o was administered to Group-3. Group-4 and Group-5 were given 20mg/kg and 40mg/kg embelin p.o. Group 6 and 7 were given embelin p.o. at a dose of 20mg and 40mg/kg respectively along with 7.5mg/kg L-Dopa p.o. Result: Administration of rotenone (2.5mg/kg) for twenty-one days to mice consecutively produced motor incoordination, decreased locomotor activity anxiety like behaviours and bradykinesia. Embelin monotherapy as well as combination therapy of embelin along with L-Dopa significantly decreased the effect of rotenone on behavioural changes and rendered neuroprotection in a dose dependant manner.
Cite this article:
Anand Koppal, Vagdevi H. R, Senthilkumar Sivanesan, Sukumar Ethirajan, Rajagopalan Vijayaraghavan. Therapeutic effect of Embelin and Levodopa combination in Rotenone induced Parkinson’s disease in mice on Neurobehavioral Changes. Research Journal of Pharmacy and Technology 2023; 16(5):2107-4. doi: 10.52711/0974-360X.2023.00346
Anand Koppal, Vagdevi H. R, Senthilkumar Sivanesan, Sukumar Ethirajan, Rajagopalan Vijayaraghavan. Therapeutic effect of Embelin and Levodopa combination in Rotenone induced Parkinson’s disease in mice on Neurobehavioral Changes. Research Journal of Pharmacy and Technology 2023; 16(5):2107-4. doi: 10.52711/0974-360X.2023.00346 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-5-5
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