Yakaiah Vangoori, Naga Vishnu Kandra, Praveen Kumar Uppala, U. Upendrarao, S.V. Saibaba, Murali Krishna Balijepalli, Butti Lavanya, SK. M. Shabana
Yakaiah Vangoori1, Naga Vishnu Kandra2, Praveen Kumar Uppala3*, U. Upendrarao4, S.V. Saibaba5, Murali Krishna Balijepalli6, Butti Lavanya7, SK. M. Shabana8
1Associate Professor, Dept. of Pharmacology, Santhiram Medical College and General Hospital, Nandyal, Kurnool, Andhra Pradesh.
2Post Graduate (M.D), Dept. of Pharmacology, Santhiram Medical College and General Hospital, Nandyal, Kurnool, Andhra Pradesh.
3Pharmacovigilance Associate, (Employee ID- IPC – 291), NCC- PvPI, Indian Pharmacopeia Commission, Ghaziabad.
4Assistant Professor, Dept. of Pharmaceutical Analysis, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh.
5Professor, Dept. of Pharmaceutical Analysis, KVK College of Pharmacy, Hyderabad. Telangana.
6Research Scholar, Centurion University of Technology and Management – CUTM, Odisha.
7Clinical Pharmacist, Santhiram Medical College and General Hospital, Nandyal, Kurnool, Andhra Pradesh.
8Assistant Professor, Dept. of Hospital and Clinical Pharmacy, K V
Volume - 16,
Issue - 5,
Year - 2023
Stevens-Johnson syndrome (SJS) is considered as serious mucocutaneous autoimmune disease which is potentially fatal. It may be initiated by medical treatment or infection and sometimes both may be triggering factors. Skin reactions involving loss of skin and mucus membrane and in severe cases, systemic symptoms may be appeared in SJS. In most of the cases medication is the causative factor. Toxic Epidermal Necrolysis (TEN) is a severe form of SJS, as it involves more than 30% of the skin surface with extensive damage to the mucous membranes. SJS and TEN are distinguished based on the extent of the detached skin surface area. It starts with flu-like symptoms, rashes with pain; the upper layer of affected skin dies, sheds and begins to heal after several days. In severe cases, it may leads to life threatening condition. Here we are presenting drug induced SJS in three different cases with different drugs. In first case, a 40-years male treated with Phenytoin 400mg for epilepsy, in second case, a 50-years male was given Amoxicillin + clavulanic acid-625 for some skin lesions and in third case, 50-years old female was given Methotrexate 7.5mg for Rheumatoid arthritis. In all the three cases, SJS symptoms were started within a period of 5-10days. All the symptoms and reactions were noticed and assessed for the confirmations of SJS.
Cite this article:
Yakaiah Vangoori, Naga Vishnu Kandra, Praveen Kumar Uppala, U. Upendrarao, S.V. Saibaba, Murali Krishna Balijepalli, Butti Lavanya, SK. M. Shabana. Case Reports of Stevens Johnson Syndrome (SJS) Induced by Chemically Unrelated Drugs. Research Journal of Pharmacy and Technology 2023; 16(5):2415-8. doi: 10.52711/0974-360X.2023.00398
Yakaiah Vangoori, Naga Vishnu Kandra, Praveen Kumar Uppala, U. Upendrarao, S.V. Saibaba, Murali Krishna Balijepalli, Butti Lavanya, SK. M. Shabana. Case Reports of Stevens Johnson Syndrome (SJS) Induced by Chemically Unrelated Drugs. Research Journal of Pharmacy and Technology 2023; 16(5):2415-8. doi: 10.52711/0974-360X.2023.00398 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-5-57
1. Rzany B. Correia O. Kelly JP. Naldi L. Auquier A. Stern R. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study Group of the International Case Control Study on Severe Cutaneous Adverse Reactions. Lancet. 1999; 353(9171): 2190 – 2194. DOI: 10.1016/s0140-6736(98)05418-x
2. Madaiah A. Gowda HN. Fatal phenytoin induced Stevens–Johnson syndrome in an elderly person with metastatic lung carcinoma. Natl J Physiol Pharm Pharmacol. 2016; 6:175–177. DOI:10.5455/njppp.2016.6.25122015109
3. Cheriyan S. Patterson R. Greenberger PA. Grammer LC. Latall J. The outcome of Stevens-Johnson syndrome treated with corticosteroids. Allergy Proc. 1995; 16(4):151–155. DOI: 10.2500/108854195778666793
4. Remya Antony et al Case report on Fluconazole Induced Stevens - Johnson Syndrome. Research Journal of Pharmacy and Technology.2019; 12(8): 3735-3738. DOI: 10.5958/0974-360X.2019.00639.5
5. Yetiv JZ. Bianchine JR. JA Owen Jr. Etiologic factors of the Stevens–Johnson syndrome. South Med J. 1980; 73(5):599–602.DOI: 10.1097/00007611-198005000-00015
6. Bianchine JR. Macaraeg PV. Lasagna L et al Drugs as etiologic factors in the Stevens–Johnson syndrome. Am J Med. 1968; 44(3):390–405. doi: 10.1016/0002-9343(68)90110-1
7. Jahirul Islam Laskar. Pinaki Chakravarty. Babul Dewan. Toxic Epidermal Necrolysis induced by Carbamazepine: a case study. Asian Journal of Pharmaceutical and Clinical Research. 2017; 10 (7): 78-81. DOI: https://doi.org/10.22159/ajpcr.2017.v10i7.18406
8. Roujeau JC. Kelly JP. Naldi L. Rzany B. Stern RS. Anderson T et al Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995; 333:1600–1607. DOI: 10.1056/NEJM199512143332404
9. Gerull R. Nelle M. Schaible T Toxic epidermal necrolysis and Stevens-Johnson syndrome: a review. Crit Care Med. 2011; 39:1521–1532. DOI: 10.1097/CCM.0b013e31821201ed
10. Tyagi S. Kumar S. Kumar A. Singla M. Singh A Stevens - Johnson Syndrome - A life threatening skin disorder: A review. J. Chem. Pharm. Res. 2010; 2(2): 618-626.