Author(s): Mukesh Sharma, Ajazuddin, Kushagra Nagori, Vishal Jain, Neema Sajju Balan


DOI: 10.52711/0974-360X.2023.00420   

Address: Mukesh Sharma1, Ajazuddin1, Kushagra Nagori1, Vishal Jain3, Neema Sajju Balan2*
1Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, India.
2G D Rungta College of Science and Technology, Bhilai, Chhattisgarh, 490024, India.
3Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023

Most of today's rapidly spreading infectious diseases are arthropod-borne, and vaccinations are powerless to prevent them. Because insect repellents are effective topical barriers to the spread of arthropod-borne infectious illnesses. Plant-based (natural) and chemical-based products are both used (synthetic) as a mosquito repellents, which come in a variety of forms such as mosquito repeller coils, mosquito repeller oil, and so on, are becoming more popular around the world as vector-borne viral diseases such as Dengue, Chikungunya, and Malaria become more prevalent. The best alternative to the optimal formulation is determined by a number of elements, including the type of repellent (natural or synthetic), medicinal forms (spray, lotion, cream, gel), duration of action (short or long), exposure environment, and user (adult, pregnant women, children, newborn). DEET, IPicaridin, and essential oils are the most commonly utilised repellents, each with its own set of benefits and drawbacks. DEET is not suggested for children under the age of six months or pregnant women because of its toxicity. The current tendency is to employ pant-based repellent active compounds like essential oils, which have minimal toxicity, are environmentally friendly, but have a shorter repellent action period due to quick evaporation after skin contact. Repellents could be a visible option for people to reduce the risk of interaction with rare mosquito-borne diseases for mosquito borne diseases. The review highlights a summary of mosquito repellents, its novel discoveries, and areaof technicalstudies such as the novel and unique repellent formulations and their potentialfuture.

Cite this article:
Mukesh Sharma, Ajazuddin, Kushagra Nagori, Vishal Jain, Neema Sajju Balan. Herbal, Safe and effective Mosquito repellents: Recent Development and Opportunity. Research Journal of Pharmacy and Technology 2023; 16(5):2557-2564. doi: 10.52711/0974-360X.2023.00420

Mukesh Sharma, Ajazuddin, Kushagra Nagori, Vishal Jain, Neema Sajju Balan. Herbal, Safe and effective Mosquito repellents: Recent Development and Opportunity. Research Journal of Pharmacy and Technology 2023; 16(5):2557-2564. doi: 10.52711/0974-360X.2023.00420   Available on:

1.    Rehman JU, Ali A, Khan IA. Plant based products: Use and development as repellents against mosquitoes: A review. Fitoterapia. 2014;95:65-74. doi:10.1016/j.fitote.2014.03.002
2.    Karunamoorthi H, Karunamoorthi K, Hailu T. Insect Repellent Plants Traditional Usage Practices in the Ethiopian Malaria Epidemic-Prone Setting: An Ethnobotanical Survey. Vol 10.; 2014.
3.    Barradas TN, Lopes LMA, Ricci E, De Holanda E Silva KG, Mansur CRE. Development and characterization of micellar systems for application as insect repellents. Int J Pharm. Published online 2013. doi:10.1016/j.ijpharm.2013.05.050
4.    Tisgratog R, Sanguanpong U, Grieco JP, Ngoen-kluan R, Chareonviriyaphap T. Plants traditionally used as mosquito repellents and the implication for their use in vector control. Acta Trop. Published online 2016. doi:10.1016/j.actatropica.2016.01.024
5.    Kumar S, Wahab N, Warikoo R. Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L. Asian Pac J Trop Biomed. 2011;1(2):85-88. doi:10.1016/S2221-1691(11)60001-4
6.    Afolabi OJ, Simon-oke IA, Elufisan OO, Oniya MO. Adulticidal and repellent activities of some botanical oils against malaria mosquito : Anopheles gambiae ( Diptera : Culicidae ). Beni-Suef Univ J Basic Appl Sci. Published online 2017:0-3. doi:10.1016/j.bjbas.2017.09.004
7.    Anuradha V, M SA, Yogananth N. Journal of Tropical Diseases Efficacy of Mosquito Repellent and Adulticidal Activities of Halophila Ovalis Extract Against Filaria Vectors. 2016;4(2):2-5. doi:10.4172/2329-891X.1000191
8.    Das NG, Dhiman S, Talukdar PK, Rabha B, Goswami D, Veer V. Synergistic mosquito-repellent activity of Curcuma longa , Pogostemon heyneanus and Zanthoxylum limonella essential oils. J Infect Public Health. 2015;8(4):323-328. doi:10.1016/j.jiph.2015.02.005
9.    Cao JQ, Guo SS, Wang Y, Pang X, Geng ZF, Du SS. Toxicity and repellency of essential oil from Evodia lenticellata Huang fruits and its major monoterpenes against three stored-product insects. Ecotoxicol Environ Saf. 2018;160:342-348. doi:10.1016/j.ecoenv.2018.05.054
10.    Govindarajan M, Rajeswary M, Arivoli S, Tennyson S, Benelli G. Larvicidal and repellent potential of Zingiber nimmonii (J. Graham) Dalzell (Zingiberaceae) essential oil: an eco-friendly tool against malaria, dengue, and lymphatic filariasis mosquito vectors? Parasitol Res. 2016;115(5). doi:10.1007/s00436-016-4920-x
11.    Barnes KM, Whi AL, Bulling MT. Journal of Archaeological Science : Reports A preliminary study on the antibacterial activity and insect repellent properties of embalming fl uids from the 18th Dynasty ( 1550 – 1292 BCE ) in ancient Egypt. 2019;25(January). doi:10.1016/j.jasrep.2019.05.032
12.    Chellappandian M, Vasantha-srinivasan P, Senthil-nathan S, et al. Botanical essential oils and uses as mosquitocides and repellents against dengue. Environ Int. 2018;113(October 2017):214-230. doi:10.1016/j.envint.2017.12.038
13.    Bhardwaj M, Bharadwaj L, Trigunayat K, Trigunayat MM. Insecticidal and wormicidal plants from Aravalli hill range of India. J Ethnopharmacol. 2011;136(1):103-110. doi:10.1016/j.jep.2011.04.013
14.    Thanigaivel A, Vasantha-Srinivasan P, Senthil-Nathan S, et al. Impact of Terminalia chebula Retz. against Aedes aegypti L. and non-target aquatic predatory insects. Ecotoxicol Environ Saf. Published online 2017. doi:10.1016/j.ecoenv.2016.11.004
15.    Anuar AA, Yusof N. Methods of imparting mosquito repellent agents and the assessing mosquito repellency on textile. Fash Text. 2016;3(1). doi:10.1186/s40691-016-0064-y
16.    Batish DR, Singh HP, Kohli RK, Kaur S. Eucalyptus essential oil as a natural pesticide. For Ecol Manage. 2008;256(12):2166-2174. doi:10.1016/j.foreco.2008.08.008
17.    Mondal NK, Chowdhury A, Dey U, et al. Green synthesis of silver nanoparticles and its application for mosquito control. Asian Pacific J Trop Dis. Published online 2014. doi:10.1016/S2222-1808(14)60440-0
18.    Diaz JH. Chemical and plant-based insect repellents: Efficacy, safety, and toxicity. Wilderness Environ Med. 2016;27(1):153-163. doi:10.1016/j.wem.2015.11.007
19.    Demirci B, Yusufoglu HS, Tabanca N, et al. Rhanterium epapposum Oliv. essential oil: Chemical composition and antimicrobial, insect-repellent and anticholinesterase activities. Saudi Pharm J. 2017;25(5):703-708. doi:10.1016/j.jsps.2016.10.009
20.    Fankhauser B, Dumont P, Hunter JS, et al. Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against Three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs. Parasites and Vectors. 2015;8(1). doi:10.1186/s13071-015-0691-y
21.    Katz TM, Miller JH, Hebert AA. new developments. 2008;(Cdc):865-871. doi:10.1016/j.jaad.2007.10.005
22.    Sfara V, Mougabure-Cueto GA, González-Audino PA. Modulation of the behavioral and electrical responses to the repellent DEET elicited by the pre-exposure to the same compound in Blattella germanica. PeerJ. Published online 2016. doi:10.7717/peerj.2150
23.    Sengupta R, Chakraborty S, Bandyopadhyay S, et al. A Short Review on Rubber / Clay Nanocomposites With Emphasis on Mechanical Properties. Engineering. 2007;47:21-25. doi:10.1002/pen
24.    Wu H, Zhang M, Yang Z. Repellent activity screening of 12 essential oils against Aedes albopictus Skuse: Repellent liquid preparation of Mentha arvensis and Litsea cubeba oils and bioassay on hand skin. Ind Crops Prod. 2019;128:464-470. doi:10.1016/j.indcrop.2018.11.015
25.    Campos D, Gravato C, Quintaneiro C, et al. Are insect repellents toxic to freshwater insects? A case study using caddisflies exposed to DEET. Chemosphere. 2016;149:177-182. doi:10.1016/j.chemosphere.2016.01.098
26.    Balaji APB, Mishra P, Suresh Kumar RS, Mukherjee A, Chandrasekaran N. Nanoformulation of poly(ethylene glycol) polymerized organic insect repellent by PIT emulsification method and its application for Japanese encephalitis vector control. Colloids Surfaces B Biointerfaces. 2015;128:370-378. doi:10.1016/j.colsurfb.2015.02.034
27.    Capinera JL. Relationships between insect pests and weeds: an evolutionary perspective. Weed Sci. 2005;53(6):892-901. doi:10.1614/WS-04-049R.1
28.    Zoubiri S, Baaliouamer A. Potentiality of plants as source of insecticide principles. J Saudi Chem Soc. 2014;18(6):925-938. doi:10.1016/j.jscs.2011.11.015
29.    Bohbot JD, Dickens JC. Odorant receptor modulation: Ternary paradigm for mode of action of insect repellents. Neuropharmacology. Published online 2012. doi:10.1016/j.neuropharm.2012.01.004
30.    Maia MF, Onyango SP, Thele M, Simfukwe ET, Turner EL, Moore SJ. Do topical repellents divert mosquitoes within a community? - Health equity implications of topical repellents as a mosquito bite prevention tool. PLoS One. 2013;8(12). doi:10.1371/journal.pone.0084875
31.    Govindarajan M, Benelli G. Eco-friendly larvicides from Indian plants: Effectiveness of lavandulyl acetate and bicyclogermacrene on malaria, dengue and Japanese encephalitis mosquito vectors. Ecotoxicol Environ Saf. Published online 2016. doi:10.1016/j.ecoenv.2016.07.035
32.    Dickens JC, Bohbot JD. Mini review : Mode of action of mosquito repellents. Pestic Biochem Physiol. 2013;106(3):149-155. doi:10.1016/j.pestbp.2013.02.006
33.    Govindarajan M. Mosquito repellent properties of Delonix elata (L.) gamble (Family: Fabaceae) against filariasis vector, Culex quinquefasciatus Say. (Diptera: Culicidae). Asian Pacific J Trop Dis. 2014;4:S194-S198. doi:10.1016/S2222-1808
34.    Govindarajan M, Sivakumar R, Amsath A, Niraimathi S. Mosquito larvicidal properties of Ficus benghalensis L. (Family: Moraceae) against Culex tritaeniorhynchus Giles and Anopheles subpictus Grassi (Diptera: Culicidae). Asian Pac J Trop Med. Published online 2011. doi:10.1016/S1995-7645(11)60135-1
35.    Chellappandian M, Vasantha-Srinivasan P, Senthil-Nathan S, et al. Botanical essential oils and uses as mosquitocides and repellents against dengue. Environ Int. 2018;113:214-230. doi:10.1016/j.envint.2017.12.038
36.    Tippanna Banne S, Girigaon YH. Medical Science Scope of Natural Pesticides in Cultivation of Medicinal Plants. IJSR -International J Sci Res. 2014;3(10).
37.    Malejky N, Nowak-chmura M. The repellent effect of plants and their active substances against the beetle storage pests. 2017;74:66-77. doi:10.1016/j.jspr.2017.10.006
38.    Mamood SNH, Hidayatulfathi O, Budin SB, Rohi GA, Zulfakar MH. The formulation of the essential oil of Piper aduncum Linnaeus ( Piperales : Piperaceae ) increases its efficacy as an insect repellent. Published online 2016. doi:10.1017/S0007485316000614
39.    Tabari MA, Youssefi MR, Maggi F, Benelli G. Toxic and repellent activity of selected monoterpenoids (thymol, carvacrol and linalool) against the castor bean tick, Ixodes ricinus (Acari: Ixodidae). Vet Parasitol. 2017;245:86-91. doi:10.1016/j.vetpar.2017.08.012
40.    Bissinger BW, Roe RM. Tick repellents : Past , present , and future. Pestic Biochem Physiol. 2010;96(2):63-79. doi:10.1016/j.pestbp.2009.09.010
41.    Dris D, Tine-Djebbar F, Bouabida H, Soltani N. Chemical composition and activity of an Ocimum basilicum essential oil on Culex pipiens larvae: Toxicological, biometrical and biochemical aspects. South African J Bot. Published online 2017. doi:10.1016/j.sajb.2017.09.013
42.    Nitin VK, Kiran AW, Manish SK. Review on standardization of herbal churna. Int J Res Ayurveda Pharm. 2014;5(3):397-401. doi:10.7897/2277-4343.05382
43.    Fankhauser B, Dumont P, Iii JSH, et al. Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species ( Aedes albopictus , Aedes aegypti and Culex pipiens ) on dogs. Parasites & Vectors (2015). 2015;8(64):1-8. doi:10.1186/s13071-015-0691-y
44.    Sardana V, Mahajan G, Jabran K, Chauhan BS. Role of competition in managing weeds: An introduction to the special issue. Crop Prot. 2017;95:1-7. doi:10.1016/j.cropro.2016.09.011
45.    Licciardello F. Development of Insect-Repellent Food Packaging Materials. In: Reference Module in Food Science. Elsevier; 2018. doi:10.1016/b978-0-08-100596-5.21465-0
46.    Susan R, Knols B, Bellini R, et al. Acta Tropica Review : Improving our knowledge of male mosquito biology in relation to genetic control programmes. Acta Trop. 2014;132:S2-S11. doi:10.1016/j.actatropica.2013.11.005
47.    Chore JK, Obonyo M, Wachira FN, Mireji PO. Larvicidal activity of selected aloe species against aedes aegypti (Diptera: Culiciade). J Insect Sci. 2014;14(1). doi:10.1093/jisesa/ieu064
48.    Karunamoorthi K, Hailu T. Insect repellent plants traditional usage practices in the Ethiopian malaria epidemic-prone setting: an ethnobotanical survey. J Ethnobiol Ethnomed. 2014;10(1):22. doi:10.1186/1746-4269-10-22
49.    Maharaj R, Maharaj V, Crouch NR, et al. Evaluation of selected South African ethnomedicinal plants as mosquito repellents against the Anopheles arabiensis mosquito in a rodent model. Malar J. Published online 2010. doi:10.1186/1475-2875-9-301
50.    Gross EM, Drouet-Hoguet N, Subedi N, Gross J. The potential of medicinal and aromatic plants (MAPs) to reduce crop damages by Asian Elephants (Elephas maximus). Crop Prot. 2017;100:29-37. doi:10.1016/j.cropro.2017.06.002
51.    Islam J, Zaman K, Tyagi V, Duarah S, Dhiman S, Chattopadhyay P. Protection against mosquito vectors Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus using a novel insect repellent, ethyl anthranilate. Acta Trop. 2017;174:56-63. doi:10.1016/j.actatropica.2017.06.024
52.    Hari I, Mathew N. Larvicidal activity of selected plant extracts and their combination against the mosquito vectors Culex quinquefasciatus and Aedes aegypti. Environ Sci Pollut Res. 2018;25(9):9176-9185. doi:10.1007/s11356-018-1515-3
53.    Jangam SS, Chaudhari PS, Chaudhari S V, Baheti KG. Herbal Plants for Insect Pest Management. 2014;5(3):882-884.
54.    Hanifah AL, Ming HT, Narainasamy VV, Yusoff AT. Laboratory evaluation of six crude plant extracts as repellents against larval Leptotrombidium deliense (Acari: Trombiculidae). Asian Pac J Trop Biomed. 2012;2(1 SUPPL.). doi:10.1016/S2221-1691(12)60170-1
55.    Govindarajan M. Larvicidal and repellent properties of some essential oils against Culex tritaeniorhynchus Giles and Anopheles subpictus Grassi ( Diptera : Culicidae ). Asian Pac J Trop Med. 2011;4(2):106-111. doi:10.1016/S1995-7645(11)60047-3
56.    Oyourou JN, Combrinck S, Regnier T, Marston A. Purification, stability and antifungal activity of verbascoside from Lippia javanica and Lantana camara leaf extracts. Ind Crops Prod. 2013;43(1):820-826. doi:10.1016/j.indcrop.2012.08.028
57.    Bissinger BW, Roe RM. Tick repellents: Past, present, and future. Pestic Biochem Physiol. 2010;96(2):63-79. doi:10.1016/j.pestbp.2009.09.010
58.    Phasomkusolsil S, Soonwera M. The effects of herbal essential oils on the ovipositiondeterrent and ovicidal activities of Aedes aegypti (Linn.), Anopheles dirus (Peyton and Harrison) and Culex quinquefasciatus (Say). Trop Biomed. Published online 2012. doi:10.1016/S2221-1691(11)60136-6

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