Background: Gugglusterone has been reported to provide protection against inflammatory and oxidative reactions of different pathological conditions. Objectives: The main object of this research work is to evaluate the renoprotective effects of guggulsterone in the prevention of cisplatin-induced nephrotoxicity in rats via assessment of renal function and histological study. Materials and methods: Rats in this study were split into four groups which comprise a control group, an induction group, a third group receiving low-dose guggulsterone, and a fourth group receiving high-dose guggulsterone. Results: a single dose of cisplatin drug has jeopardisedrenal physiology that has been demonstrated in histopathology sections and elevation of serum creatinine and urea concentrations. However, concurrent use of Guggulsteronehas provided improved histological findings and significantly (P<0.05) reduced serum creatinine and urea levels compared to the positive control of cisplatin-induced damage. Conclusion:Guggulsteronehas provided a potentially reasonable protective kidney effect against vitiated insults.
Cite this article:
Ruya Ali Albayaty, Munaf Zalzala. Renoprotective effects of Guggulsterone against Cisplatin-Induced Kidney Damage in White Female Albino Rats. Research Journal of Pharmacy and Technology 2023; 16(5):2133-6. doi: 10.52711/0974-360X.2023.00350
Ruya Ali Albayaty, Munaf Zalzala. Renoprotective effects of Guggulsterone against Cisplatin-Induced Kidney Damage in White Female Albino Rats. Research Journal of Pharmacy and Technology 2023; 16(5):2133-6. doi: 10.52711/0974-360X.2023.00350 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-5-9
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