Author(s): Nanditha Bhat, Abhishek Kumar, Pankaj Kumar, Aravinda Pai

Email(s): abhi12bunty@nitte.edu.in

DOI: 10.52711/0974-360X.2023.00455   

Address: Nanditha Bhat1, Abhishek Kumar1*, Pankaj Kumar1, Aravinda Pai2
1Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS) Department of Pharmaceutical Chemistry, Mangalore, India.
2Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences (MCOPS), Department of Pharmaceutical Chemistry, Manipal, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 6,     Year - 2023


ABSTRACT:
Oxadiazoles, a class of five membered heterocyclic azoles, are considered to be a versatile scaffold and is found to be a core moiety of various pharmaceutically active agents.Oxadiazoles are known to inhibit alpha-amylase and alpha-glucosidase enzyme which is rational approach for selecting oxadiazole as antidiabetic agents in controlling postprandial hyperglycemia in type II diabetes mellitus. They are found to exist in 4 different regioisomeric forms namely 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole and 1,3,4-oxadiazole. Oxadiazoles are known to exhibit a wide range of biological activities and many mono and di-substituted oxadiazoles have been studied for their antihyperglycemic potential. Oxadiazoles have been found to act on various potential targets of the antidiabetic therapy. They are found to elicit hypoglycemic action by different mechanisms like inhibition of digestive enzymes, insulin sensitization, reduction of renal glucose reabsorption, etc. The results of various substituted oxadiazoles studied for their anti-diabetic activity has been reviewed in this article.


Cite this article:
Nanditha Bhat, Abhishek Kumar, Pankaj Kumar, Aravinda Pai. A Comprehensive Review on the Antidiabetic Activity of Oxadiazole Derivatives. Research Journal of Pharmacy and Technology 2023; 16(6):2771-2775. doi: 10.52711/0974-360X.2023.00455

Cite(Electronic):
Nanditha Bhat, Abhishek Kumar, Pankaj Kumar, Aravinda Pai. A Comprehensive Review on the Antidiabetic Activity of Oxadiazole Derivatives. Research Journal of Pharmacy and Technology 2023; 16(6):2771-2775. doi: 10.52711/0974-360X.2023.00455   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-6-33


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