Author(s):
Swamita Arora, Priti Tagde, Sanjar Alam, Wasim Akram, Sangeetha Gupta
Email(s):
sgupta23@amity.edu
DOI:
10.52711/0974-360X.2023.00466 
Address:
Swamita Arora1, Priti Tagde1, Sanjar Alam2, Wasim Akram2, Sangeetha Gupta1*
1Amity Institute of Pharmacy, A -Block, Amity University, Sector-125, Noida-U.P.-201303, India.
2Department of Pharmacology, R. V. Northland Institute of Pharmacy, Gautam Buddh Nagar, U.P.-203207, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 6,
Year - 2023
ABSTRACT:
The purpose of this work was to explain how TLR3/dsRNA complex inhibitor-calbiochem affects allergic inflammation of the airways. The identification of double-stranded RNA (dsRNA) is facilitated by the TLR3 in a significant way. Mice were subjected to Poly (I: C) as a model of asthma being sensitized and challenged with PBS and ovalbumin (OVA) chemicals. TLR3/dsRNA complex inhibitor was given to the mice. Throughout the trial, body mass scaling was used to estimate the effect of drugs in mice. Lung interstitial protein and enzyme content in airways are assessed by biochemical parameters. TLR3/dsRNA complex inhibitor drastically improved the percentage of antioxidant markers like MDA, GSH, GPx and CAT in lung tissues as well as maintained the body weight throughout the treatment period in experimental animals. It is anticipated that a new TLR3/dsRNA complex inhibitor will be used clinically since it inhibits airway inflammation without causing viral treatment resistance.
Cite this article:
Swamita Arora, Priti Tagde, Sanjar Alam, Wasim Akram, Sangeetha Gupta. Role of Toll-like receptor-3 antagonist on viral load of Asthma in Swiss Albino Mice. Research Journal of Pharmacy and Technology 2023; 16(6):2829-4. doi: 10.52711/0974-360X.2023.00466
Cite(Electronic):
Swamita Arora, Priti Tagde, Sanjar Alam, Wasim Akram, Sangeetha Gupta. Role of Toll-like receptor-3 antagonist on viral load of Asthma in Swiss Albino Mice. Research Journal of Pharmacy and Technology 2023; 16(6):2829-4. doi: 10.52711/0974-360X.2023.00466 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-6-44
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