Author(s): Subbulakshmi Packirisamy, Valli Gunam, Jaideep Mahendra, Deepa Rajendran, Ponnulakshmi Rajagopal

Email(s): subbulakshmi@madch.edu.in , Subbu.buvi@gmail.com

DOI: 10.52711/0974-360X.2023.00698   

Address: Subbulakshmi Packirisamy1, Valli Gunam2, Jaideep Mahendra3, Deepa Rajendran4, Ponnulakshmi Rajagopal5
1Lecturer, Department of Pharmacology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, Tamilnadu.
2Professor, Department of Pharmacology, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, Tamilnadu.
3Professor, Department of Periodontology, Meenakshi Ammal Dental College and Hospital
4Associate Professor, Department of Biochemistry, Madha Dental College and Hospital, Kundrathur,Chennai, Tamilnadu.
5Scientist, Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, Tamilnadu.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
Objective: Picrorhiza kurroa Royle ex Benth. (Scrophulariacae) is a herb in the Ayurvedic system of medicine highly noted for its hepatoprotective effect. Over exploitation for various medicinal purposes has made the rhizome as an endangered species. In spite of its geographical distribution, it is available in all the herbal drug stores. The rationale behind this study is to authenticate and standardize the Picrosides by different parameters to enable its identity, purity and efficacy. Thus, the Present study analyzed the presence of phytochemicals qualitatively and evaluated the antioxidant properties in the methanolic extracts of Picrorhiza kurroa. Methods: Preliminary analysis of phytoconstituents of root parts of this plant using the standard procedures and Antioxidant properties were determined by 1,1- diphenyl,2-picrylhydrazyl (DPPH) assay. Results: The qualitative phytochemical analysis revealed the presence of secondary active constituent’s such as glycosides, cardiacglycosides, Tannins, terpenoids, steroids and coumarins and also possesses high free radical scavenging property. Conclusion: Therefore this study explored the antioxidant properties which strongly supports that could prevent many free radical related disorders. Also paves the way for further quantitative and animal studies, planned to explore the molecular mechanisms for the study based on cardiovascular disorders.


Cite this article:
Subbulakshmi Packirisamy, Valli Gunam, Jaideep Mahendra, Deepa Rajendran, Ponnulakshmi Rajagopal. Preliminary Phytochemical screening and Antioxidant properties of Methanolic root extract of Picrorhiza kurroa. Research Journal of Pharmacy and Technology 2023; 16(9):4266-0. doi: 10.52711/0974-360X.2023.00698

Cite(Electronic):
Subbulakshmi Packirisamy, Valli Gunam, Jaideep Mahendra, Deepa Rajendran, Ponnulakshmi Rajagopal. Preliminary Phytochemical screening and Antioxidant properties of Methanolic root extract of Picrorhiza kurroa. Research Journal of Pharmacy and Technology 2023; 16(9):4266-0. doi: 10.52711/0974-360X.2023.00698   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-9-42


REFERENCE:
1.    Rangarajan Narasimhan, Sathiyamoorthy. M. Phytochemical Screening and Antioxidant Studies in the Pulp Extracts of Cucurbita maxima. Asian J. Pharm. Res. 2016; 6(1): 01-04. doi: 10.5958/2231-5691.2016.00001.0
2.    Deepa Rajendiran, Subbulakshmi Packirisamy, K Gunasekaran. A review on role of antioxidants in diabetes. Asian J Pharm Clin Res. 2018.  DOI: https://doi.org/10.22159/ajpcr.2018.v11i2.23241
3.    Mishra P, Yadav KS, Gautam G. Comparative qualitative and quantitative phytochemical analysis of Calotropis gigantea and Calotropis procera roots,Journal of Drug Delivery and Therapeutics. 2018; 8(4):179 -184 http://jddtonline.info/index.php/jddt/article/view/1757
4.    Mukherjee PK. Quality Control of Herbal Drugs. 2nd Edition. Business Horizons; 2007.P. 2 -14
5.    P. Muthukumaran, S. Salomi, R. Umamaheshwari. In vitro Antioxidant Activity of Premna serratifolia Linn. Asian J. Res. Pharm. Sci. 2013; 3(1): 15-18.
6.    Subbulakshmi P, Valli G, Bettina, Deepa R. A Phytopharmacological Review on an Endangered Magical Herb- Picrorhiza Kurroa. Journal of Emerging Technologies and Innovative Research (JETIR). 2021; 8(12): 159-173
7.    Mrunali Potbhare, Nikhita Phendarkar, Deepak Khobragade. In vitro Evaluation of Antioxidant Potential of N –Acetyl-D-Glucosamine. Asian J. Res. Pharm. Sci. 2017; 7(2): 120-122.
8.    Ram Kumar Sahu, Harideep Singh, Amit Roy. Antioxidative characteristics of ethanol and aqueous extracts of Curcuma amada rhizomes. Research J. Pharmacognosy and Phytochemistry. 2009; 1(1): 41-43 .
9.    Maria Masood, Muhammad Arshad, Rahmatullah Qureshi, Sidra Sabir, Muhammad Shoaib Amjad, Huma Qureshi and Zainab Tahir. Picrorhiza kurroa: An ethnopharmacologically important plant species of Himalayan region. Pure and Applied Biology.  2015; 4(3): 407-417.  
10.    Deepika Soni, Abhinav Grover. “Picrosides” from Picrorhiza kurroa as potential anti-carcinogenic agents. Biomedicine and Pharmacotherapy. 2019; 109: 1680- 1687
11.    Salma et al. Phytochemistry and Pharmaceutical Significance of Picrorhiza kurroa Royle ex Benth. Phytochem. and Pharm. of Med. Herb. 2017; 26-37.
12.    Trease, G.E., Evans, W.C. 1989. Pharmacognosy, 11th edn., Bailliere Tindall, London, pp. 45-50
13.    Harborne, J.B. 1973. Phytochemicals Methods. Chapman and Hall Ltd., London, pp. 49-188.
14.    Sofowra, A. 1993. Medicinal Plants And traditional Medicine In Africa. Spectrum Books Ltd., Ibadan, Nigeria, pp. 191-289.
15.    Kharel, R., and K. Raj Sharma. Evaluation of antioxidant potential and quantitative estimation of phenolic and flavonoid content in some selected nepalese medicinal plants. Asian Journal of Pharmaceutical and Clinical Research. 2020; 13(1): 124-8,
16.    Ahmed, M, Saeed, F, et al. Evaluation of Insecticidal and Antioxidant activity of selected Medicinal plants. Journal of Pharmacognosy and Phytochemistry.  2013; 2(3): 153-158.
17.    Leaves, L. Antioxidant Activity by DPPH Radical Scavenging Method of Ageratum conyzoides. Orient. 2014; 1(4): 244–249.
18.    Amit Roy, Dayananda Bhoumik, Ram Kumar Sahu, Jaya Dwivedi. Phytochemical Screening and Antioxidant Activity of Sesbania grandiflora Leaves Extracts. Asian J. Res. Pharm. Sci. 2014; 4(1): 16-21.
19.    Suraj Kumar Behera. Phytochemical screening and antioxidant properties of methanolic extract of root of Asparagus racemosus Linn, International Journal of Food Properties. 2018; 21(1): 2681-2688, DOI: 10.1080/10942912.2018.1560310
20.    Packirisamy S, Magdaline BL, Dhanavel A, Rajendiran D and Vijayashree RJ. Preliminary screening and evaluation of Commiphora caudata leaf extract on cariogenic pathogens. Int J Pharm Sci and Res. 2022; 13(10): 4159-65. doi: 10.13040/IJPSR.0975-8232.13(10).4159-65.
21.    K Amutha , D Victor Arokia Doss. In Vitro Antioxidant Activity of Ethanolic Extract of Barleria cristata L. Leaves. Research J. Pharmacognosy and Phytochemistry 2009; 1(3): 209-212.
22.    Basavaraj H, Purnima Ashok. In – vitro antioxidant activity of aqueous and ethanolic extract of Coscinium fenestratum root and Embelia ribes flower. Research J. Pharm. and Tech. 2012; 5(4): 513-517.
23.    Kaniz Fatima Urmi, Ashraf Uddin Chowdhury, Farhana Diba, Khandaker Ashfaqur Rahman, Razibul Habib, Kaiser Hamid. Evaluation of Antioxidant and Cytotoxic Potential of Different Extracts from the Leaves of Aegle marmelos L. Research J. Pharm. and Tech. 2013; 6(4): 384-387.
24.    Pandey Manisha, Verma Rohit K, Dharamveer, Koshy MK , Saraf Shubhini A. Antioxidant Activity of Sida veronicaefolia. Research J. Pharmacognosy and Phytochemistry. 2010; 2(1): 79-81.
25.    Jinsu Mathew, Kavita Maria Arora, Akash Mazumdar, Gaurav Kumar, Loganathan Karthik, Kokati Venkata Bhaskara Rao. Evaluation of phytochemical composition and antioxidant activity of aqueous extract of Barleria mysorensis and Furcraea foetida leaves. Research J. Pharm. and Tech. 2012; 5(12): 1503-1508.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available