Author(s): Bipasha Behera, Uma Shankar Mishra, Sudhir Kumar Sahoo

Email(s): nootadivya13@gmail.com

DOI: 10.52711/0974-360X.2023.00707   

Address: Bipasha Behera1*, Uma Shankar Mishra2, Sudhir Kumar Sahoo3
1Institute of Pharmacy and Technology, Salpur, Dist. Cuttack, Orissa, India – 754202.
2,3Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur, Dist: Ganjam, Odisha, India – 760002.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
The objective of the present research work was to develop an innovative, simple, and economic method for estimation of Vilazodone in bulk and dosage form by RP-HPLC. The chromatographic conditions were performed on Phenomenex Luna C18, 100A, 5µm, 250mm x 4.6mm i.d.as stationary phase and mobile phase was prepared with a mixture of Phosphate Buffer: Acetonitrile = 30:70 (pH-7.6) flow 1.0ml/min, with Injection Volume 20µl, at detection wavelength 238nm and run time at 8.0 min.The analytical method is validated for estimation of vilazodone over a range of 06µg/ml–16µg/ml. The results of system suitability test, linearity, precision and accuracy, robustness, specificity, LOD and LOQ and stabilities presented in this report are within the acceptance range.A specific, sensitive, economic method estimation of vilazodone has been developed based on ICH Guidelines with bulk and dosage forms.


Cite this article:
Bipasha Behera, Uma Shankar Mishra, Sudhir Kumar Sahoo, Development and Validation of Stability Indicating RP-HPLC Method for The Analysis of Vilazodone in Bulk form and Marketed Pharmaceutical Dosage Form, Research Journal of Pharmacy and Technology 2023; 16(9):4319-4. doi: 10.52711/0974-360X.2023.00707

Cite(Electronic):
Bipasha Behera, Uma Shankar Mishra, Sudhir Kumar Sahoo, Development and Validation of Stability Indicating RP-HPLC Method for The Analysis of Vilazodone in Bulk form and Marketed Pharmaceutical Dosage Form, Research Journal of Pharmacy and Technology 2023; 16(9):4319-4. doi: 10.52711/0974-360X.2023.00707   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-9-51


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