Author(s): Sanggap Indra Sitompul, Budi Susetyo Pikir, Aryati, Shafira Kurnia Supandi, Monika Estherlita Sinta

Email(s): bsp49@fk.unair.ac.id , aryati@fk.unair.ac.id

DOI: 10.52711/0974-360X.2024.00035   

Address: Sanggap Indra Sitompul1,2, Budi Susetyo Pikir3*, Aryati4*, Shafira Kurnia Supandi5, Monika Estherlita Sinta6
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Cardiologist, Doris Sylvanus Hospital, Palangka Raya, Indonesia.
3Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
4Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
5Department of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
6Periodontist, Doris Sylvanus Hospital, Palangka Raya, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
Periodontitis is independently related to coronary heart disease and significantly impacts the quality of human life. The aim of this study was to investigate the relationship between the severity of chronic periodontitis and the severity of coronary artery stenosis in CHD patients. A total of 75 subjects were recruited for this study. The severity of the coronary artery was measured by coronary angiography. Quantitative coronary angiography (QCA) was conducted to determine 1 vessel disease (VD), 2 VD, and 3 VD, followed by stenosis. The severity of chronic periodontitis was determined based on the mean periodontal pocket depth (Mean PPD). The < 4 mm and 4 mm scores were categorized as mild and moderate-severe, respectively. Statistical analysis was conducted to determine the relationship between periodontitis and coronary artery by chi-square and followed by multivariate analysis using an ordinal regression test with a 95% confidence interval. P value < 0.05 was considered statistically significant. The proportion of moderate-severe periodontitis was more dominant than mild periodontitis. 79.20% and 20.80% of subjects were categorized as moderate-severe periodontitis and mild periodontitis in the 3 VD group. In groups 1 and 2 VD, the proportion of mild periodontitis was higher than moderate-severe periodontitis (61.30% vs. 38.7%) and (70% vs. 30%), based on bivariate analysis of the involvement of the coronary artery. Multivariate analysis showed chronic periodontitis and dyslipidemia had estimates of 1.084 (95% CI range 0.162 - 2.006) and 1.141 (95% CI range 0.217 - 2.066) for the severity of coronary artery involvement with p-values of 0.021 and 0.016, respectively. Gender, age, smoking, DM, hypertension, and obesity were not statistically significant. A significant relationship between moderate-severe chronic periodontitis was found, followed by an increase in the severity of coronary artery compared to mild chronic periodontitis.


Cite this article:
Sanggap Indra Sitompul, Budi Susetyo Pikir, Aryati, Shafira Kurnia Supandi, Monika Estherlita Sinta. Correlation Between the Severity of Chronic Periodontitis and Coronary Artery Stenosis Involvement in Coronary Heart Disease (CHD) Patients. Research Journal of Pharmacy and Technology. 2024; 17(1):222-8. doi: 10.52711/0974-360X.2024.00035

Cite(Electronic):
Sanggap Indra Sitompul, Budi Susetyo Pikir, Aryati, Shafira Kurnia Supandi, Monika Estherlita Sinta. Correlation Between the Severity of Chronic Periodontitis and Coronary Artery Stenosis Involvement in Coronary Heart Disease (CHD) Patients. Research Journal of Pharmacy and Technology. 2024; 17(1):222-8. doi: 10.52711/0974-360X.2024.00035   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-1-35


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