Author(s): Deepak Kumar Hati, Pratap Kumar Sahu, Saroj Kumar Patro


DOI: 10.52711/0974-360X.2024.00036   

Address: Deepak Kumar Hati1*, Pratap Kumar Sahu1, Saroj Kumar Patro2
1School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha.
2Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024

Ayurveda is the world's oldest and most complete spiritual teachings, as well as the "oldest medicinal system" known to man. Ayurvedic treatments along with natural substances do not have any usual side effects as contemporary drugs. The cannabis plant has been used as a medicine for thousands of years to treat various illnesses including gastrointestinal disorders. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well-known and researched phyto cannabinoids, with impressive therapeutic properties for a variety of neurological, gastrointestinal, ophthalmic, and skin problems. Cannabis and cannabinoids are beneficial in healing the sign and symptoms of several gastrointestinal diseases, according to research, in part because they interact with the digestive tracts endogenous cannabinoid receptors. This could help in relaxing pain and cramps, reducing discomfort, and improving motility. Many Indian classical formulations were found cannabis is used processing agent in pharmaceuticals. For the treatment of GI issues, there are some popular cannabis-based ayurveda or herbal formulations on the market. CBD levels are frequently higher in medical marijuana, while THC levels are lower. For certain people, the therapeutic CBD is desirable for medicinal purposes, but the psychoactive THC may be needless and undesired. There are numbers of traditional cannabis formulations on the market that lack standardised quality control parameters and methods of evaluation.So, there is a need to develop a standardization technique with special reference to CBD and THC content to include this system of medicine in the main stream of health science. Standardization of popular Ayurvedic or herbal formulations is essential in order to assess the quality, safety, efficacy of that.

Cite this article:
Deepak Kumar Hati, Pratap Kumar Sahu, Saroj Kumar Patro. Therapeutic uses of Cannabis in Indian Traditional medicine with attention on Gastrointestinal disorders. Research Journal of Pharmacy and Technology. 2024; 17(1):229-5. doi: 10.52711/0974-360X.2024.00036

Deepak Kumar Hati, Pratap Kumar Sahu, Saroj Kumar Patro. Therapeutic uses of Cannabis in Indian Traditional medicine with attention on Gastrointestinal disorders. Research Journal of Pharmacy and Technology. 2024; 17(1):229-5. doi: 10.52711/0974-360X.2024.00036   Available on:

1.    Sherekar P, Shinde NG. Ayurveda: A Need of Hours. Res. J. Pharmacognosy and Phytochem. 2019; 11(4): 229-230. doi: 10.5958/0975-4385.2019.00039.6.
2.    V. Kumar, Antil M, Kumar D, Minocha N, Ankur. Importance of ayurvedic medicine in modern lifestyle: A keynote review study. International Journal of Advanced Educational Research. 2016; 1(4): 31-33. available on
3.    Kumar,S ,.Dobos GJ, Rampp T. The Significance of Ayurvedic Medicinal Plants. Journal of Evidence-Based Complementary & Alternative Medicine. 2017; 22(3): 494-501. doi:10.1177/2156587216671392. available on
4.    Aarti, Devashree Y . The Phytotoxic Effect of Aqueous extract of Cannabis Sativa on the Germination and Growth of Cicer arietinum. Research J. Pharm. and Tech. 2018; 11(11): 5096-5100. Doi: 10.5958/0974-360X.2018.00930.7.
5.    Aggarwal KK, Gupta I.Bhang or Marijuana is Legal in Ayurvedic Prescription.Indian Journal of Clinical Practice. 2019; 30(6): 562-569.
6.    Kuddus  M. , Ibrahim AMG,  Al-Hazimi  A. Cannabis sativa: An ancient wild edible plant of India. Emir. J. Food Agric. 2013; 25(10): 736-745. doi: 10.9755/ejfa.v25i10.16400. available on
7.    Sharma K, Rana R, AshawatMS. Preliminary Phytochemical Screening of Leaves, Stems and Roots of wild Cannabis sativa. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1): 19-2. doi:10.52711/0975-4385.2022.00004.available on View 2022-14-1-4.
8.    Srivastava A, Yadav VK.Microscopical and Chemical Study of Cannabis sativa.Journal of  Forensic Research. 2013; 5(1):1-6. doi:10.4172/2157-7145.1000210. available on
9.    Sharma K,Rana R,Ashawat MS. Preliminary Phytochemical Screening of Leaves, Stems and Roots of wild Cannabis sativa. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1): 19-2. doi: 10.52711/0975-4385.2022.00004.
10.    Audu BS, Ofojekwu PC,  Ujah A, Ajima MNO. Phytochemical, proximate composition, amino acid profile and characterization of Marijuana (Cannabis sativaL.) The Journal of Phytopharmacology. 2014; 3(1): 35-43. available on
11.    ElSohly MA, Radwan  MM, Gul W , Chandra S, Galal A. Phytochemistry of Cannabis sativa L. In Phytocannabinoids, Progress in the Chemistry of Organic Natural Products.,edited by Springer International Publishing Switzerland. 2017:2-18.doi: 10.1007/978-3-319-45541-9-1.
12.    Pathak T, Kumar R, Kaur J, Kumar K. Isolation of L-Asparaginase from Cannabis Sativa and Development of Biosensor for Detection of Asparagine in Leukemic Serum Samples. Research J. Pharm. and Tech. 2014; 7(8): 850-855. doi: 10.5958/0974-360X .
13.    Bashashati M, McCallum RW.Cannabis in Gastrointestinal Disorders in Gastrointestinal motility and functional bowel disorders, series -4.2014.pp 36-45. available
14.    Kaushik S, Satapathy T, Roy A,Gupta PP,Purabiya P. Endocannabinoid activation and polycystic ovary syndrome: A systematic review. Research J. Pharm. and Tech. 2020; 13(1): 448-452. doi: 10.5958/0974-360X.2020.00087.6
15.    Gotfried J, Naftali T, Schey R. Role of Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease. Gastroenterology 2020;159:62–80. available on
16.    Gyires  K, Zádori ZS. Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Current Neuropharmacology. 2016; 14(8): 935-951.  doi:10.2174/1570159X14666160303110150.
17.    Yunna Lee, Jeongbin Jo, Hae Young Chung  CharalabosPothoulakis, and EunokIm Am J  PhysiolGastrointest Liver Physiol 311: G655–G666, 2016. First published August 18, 2016; doi:10.1152/ajpgi.00294.2015.
18.    Cencioni MT, Chiurchiu `V, Catanzaro G, Borsellino G, Bernardi G.Anandamide Suppresses Proliferation and Cytokine Release from Primary Human T-Lymphocytes Mainly via CB Receptors. Plus one, 2010; 5(1): e8688.
19.    Acharya R, Dhiman KS,  Ranade A, Naik R, Prajapati S, Lal SK. Vijaya (Cannabis sativa L.) and its therapeutic importance in ayurveda: a review. Journal of Drug Research in Ayurvedic Sciences. 2015;1(1):1-12.Avilabiale on
20.    Dwarakanath C. Use of opium and cannabis in the traditional systems of medicine in Indian Bullition of Narcotics. 1965; 17: 15-19.avilable on 1965-01-01
21.    Singh R, Panda P, Laxman  B, Singh H et al. Journal of Research in Ayurvedic Sciences .2017; 1(3): 136-141.doi:10.5005/jp-journals/10064-0015 General guidelines for drug Development of ayurvedic Formulations Vol 1. Central Council for Research in Ayurvedic Sciences Ministry of AYUSH, Govt, of India New Delhi,1st Editation,2018.
22.    General Guidelines for Drug Development of Ayurvedic Formulations Vol 1. Central Council for Research in Ayurvedic Sciences Ministry of AYUSH, Govt, of India New Delhi,1st Edition,2018
23.    Parasuraman S, Thin GS, Dhanara SA. Polyherbal formulation: Concept of ayurveda. Pharmacognosy Reviews. 2014; 8(16): 73-80. DOI: 10.4103/0973-7847.134229.
24.    Classical ayurvedic prescriptions For Common diseases, Central Council for Research in Ayurveda and Siddha Department of AYUSH, Ministry of Health & Family Welfare Government of India, New Delhi
25.    Malabadi, RB, Kolkar KP,Acharya M,Chalanvar R. Constipation-a major health disorder: role of herbal medicine treatmentinternational Journal of Innovation Scientific Research and Review. 2022;  4(4): 2634-2645. available online at
26.    Vakili M., Ahmadipour S, Rahmani P. Concise review: Herbal remedies and herbal plants for constipation in children, Biomedical Research and Therapy. 2018, 5(5): 2260-2267. DOI: 10.15419/bmrat.v5i5.438.
27.    Das SK,Das A, Das B, Panda P, Bhuyan GC,Khuntia BP. Important uses of Amalaki (Emblica officinalis) in Indian system of Medicine with Pharmacological Evidence. Res. J. Pharmacology and Pharmacodynamics. 2017; 9(4): 202-206. doi: 10.5958/2321-5836.2017.00036.2
28.    Yadav B.,Mahajon B, Dubey  et al. Traditional Ayurveda Medicines for the Management  of Amlapitta (Functional Dyspepsia): A Study Protocol  for a Prospective, Single-arm, Open-label Clinical Tria. Journal of Research in Ayurvedic Sciences.  2019; 3(2).doi: 10.5005/jras-10064-0080.
29.    Kour B. Ayurvedic Treatment for Digestion Related Problems Int. J Complement Alt Med. 2016,; 4(4): 128. DOI: 10.15406/ijcam.2016.04.00128
30.    Janardan Panday (2016, Jun 09) Ajirna (Indigestion) National helath portal,india
31.    Bhaishaja Ratnavali Shastri Ambikadatta (2008). Bhaishajyaratnavali of Govind Das edited with ‘Vidyotani’ hindi commentary. Chaukhambha Sanskrit Samsthan Varanasi.
32.    Mishra A, SharmaV, Hem K, Maurya SK.Plants used for treatment of diarrhea: an ayurvedic prospective. Innovare Journal of Ayurvedic Sciences, 2015; 3(1): 1-6. available on
33.    Patil D, Babel B, and  Chitte S.Atisaar (diarrhea): a review based on ayurveda and modern perspective,World Journal of Pharmaceutical and Medical Research.2017,3(7), 227-229.
34.    Mangesh V Tote, Ashutoshpal Jain, Nitin B Mahire, Vaishali R Undale, Ashok V Bhosale. Evaluation of Antidiarrhoeal Activity of Hydroalcoholic Extract of Ageratum Conyzoides Linn. Research J. Pharmacognosy and Phytochemistry. 2009; 1(1): 26-29.
35.    Prerna Dubey, Sumithra. M, Chitra. V. Assessment of Inflammatory Bowel Disease and its Herbal Cure: A Review. Research J. Pharm. and Tech. 2019; 12(3): 1432-1440. doi: 10.5958/0974-360X.2019.00238.5.
36.    Panda AK, Rath KK. Ayurvedic treatment outcome for Chronic Liver diseases. Journal of Ayurveda and Integrated Medical Sciences. 2019; 4(6): 190-193. available on
37.    Rotwar DS, DixitAK, Mangal A, Jadhav A.Therapeutic management of pravahika (amoebic dysentery) through ayurvedic regimen: a case study.Int. J. Ayur. Pharma Research. 2017; 5(2): 37
38.    Peshala KK,Singh ,Sahu M.Ayurveda approach for management of ulcerative colitis: a review.Int. J. Res. Ayurveda Pharm. 2019; 10(1): 21-25. doi: 10.7897/2277-4343.10016
39.    Kumari V, Kaushal K. Ayurvedic herbs useful in gastrointestinal cancer.Journal of Medicinal Plants Studies 2017; 5(1): 26-28. available on
40.    Sastry JLN. Introduction to oncology, cancer in Ayurveda. Varanasi: Chaukhambhaorientalia, 2001, 1-24.
41.    Singh k. Verma B. Scope of herbals antihelmintics: An ayurvedic prosepective. International Journal of Res. Ayurveda Pharmacy .Aug 2013; 4(4): 589-593.doi:10.7897/2277-4343.04428
42.    Chen RP, Yadav AK. In vitro anthelmintic evaluation of common Indian Ayurvedic anthelmintic drugs: Krimimudgar Ras, Kriminol and Vidangasava against intestinal helminths. Humanitis Medicine. 2018; 8(3): e15.
43.    Gayathiri. N. M, Sudhakar P, Manimekalai P, Sabarinath C. In Vitro Anti-helminthic Activity of hydroalcoholic extract of Martynia annua L. and Pentanema indicum. Research J. Pharm. and Tech. 2019; 12(8): 3847-3850. doi: 10.5958/0974-360X.2019.00660.7
44.    KotrannavarSV. Rasaushadh is in the management of hemorrhoids. Journal of Preventive Medicine and Holistic Health.  2019; 5(2): 77-80.
45.    V. J. Tiwari. Rationale Behind Ethnopharmacological Uses of Blumea lacera (Burmf.) DC., (Asteraceae) for piles/haemorrhoids and anal fissures by Madia-Gond Tribe of Gadchiroli District of Maharashtra State, India. Res. J. Pharmacognosy and Phytochem. 2016; 8(4): 235-241. doi: 10.5958/0975-4385.2016.00035.2; 8(4): 53-59   Available on:
46.    Tavhare S, Acharya R. Bhanga (Cannabis sativa L.) as an activity potentiator in Ayurvedic classics and Indian alchemy (Rasashastra): A critical review.International Journal of Ayurvedic Medicine. 2016; 7(3): 136-152.
47.    Tavhare SD, Acharya R. Exploring the pharmaco-clinical view on Bhanga (Cannabis sativa linn.): a classical unfamiliar portrayal.International Journal of Pharmaceutical & Biological Archives. 2017; 8(6): 59-78. avilabiale on
48.    L. Kaviarasan, S. Sarojini, G. Prakash Yoganandam, V. Gopal. Preparation and Standardization of Deepavali Avaleha - A Traditional Polyherbal Ayurvedic Formulation. Asian J. Pharm. Tech. 2016; 6(4): 231-237. doi: 10.5958/2231-5713.2016.00034.9

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