Author(s):
Prawati Nuraini, Dimas Prasetianto Wicaksono, Ardianti Maartrina Dewi, Adinda Ayu Fitriana, Sili Han
Email(s):
prawati-n@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2024.00726 
Address:
Prawati Nuraini1,3, Dimas Prasetianto Wicaksono1,3, Ardianti Maartrina Dewi1,3, Adinda Ayu Fitriana2, Sili Han4,5
1Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
3Academic Dental Hospital, Universitas Airlangga, Surabaya, Indonesia.
4State Key Laboratory of Oral Disease and National Clinical Hospital of Stomatology, Sichuan University, Chengdu, China.
5Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
Streptococcus gordonii, an early colonizing bacterium, can pave the way for subsequent oral health complications. Some studies suggest that S. gordonii may possess a mild cariogenic effect, as it facilitates the attachment of Streptococcus mutans to tooth surfaces. Biofilm adherence is the first stage in the biofilm formation process, while glycolytic pH is a crucial aspect of bacterial physiology. Numerous herbal antimicrobial agents have been investigated as alternatives to inhibit both biofilm adherence and glycolytic pH regulation in bacteria. One such agent is epigallocatechin gallate (EGCG). Previous literature has demonstrated the effectiveness of EGCG in inhibiting biofilm adherence and glycolytic pH reduction in S. mutans. This study aimed to investigate whether EGCG affects biofilm adherence and glycolytic pH in S. gordonii when cultured in Brain Heart Infusion Broth (BHIB) media. In vitro experiments were conducted using four groups of samples subjected to five treatments. The normal control group included BHIB + S. gordonii, the negative control group comprised BHIB + S. gordonii + 5% sucrose, and the treatment group comprised BHIB + S. gordonii + 5% sucrose with varying EGCG concentrations (0.03, 0.06, and 0.12 mg/mL). EGCG reduced the adherence of S. gordonii and increased glycolytic pH at an effective inhibitory concentration of 0.03 mg/mL. EGCG influences both biofilm adherence and glycolytic pH in S. gordonii.
Cite this article:
Prawati Nuraini, Dimas Prasetianto Wicaksono, Ardianti Maartrina Dewi, Adinda Ayu Fitriana, Sili Han. Effects of Epigallocatechin gallate on Biofilm adherence and Glycolytic pH in Streptococcus gordonii. Research Journal of Pharmacy and Technology. 2024; 17(10):4711-6. doi: 10.52711/0974-360X.2024.00726
Cite(Electronic):
Prawati Nuraini, Dimas Prasetianto Wicaksono, Ardianti Maartrina Dewi, Adinda Ayu Fitriana, Sili Han. Effects of Epigallocatechin gallate on Biofilm adherence and Glycolytic pH in Streptococcus gordonii. Research Journal of Pharmacy and Technology. 2024; 17(10):4711-6. doi: 10.52711/0974-360X.2024.00726 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-11
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