Author(s):
Prostodusheva T.V., Kiselevskii M.V., Bokov D.O., Zaichikova S.G., Antsyshkina A.M., Bobkova N.V., Strelyaeva A.V., Konovalchik D.A., Rodin M.N., Shalburova S.G.S.
Email(s):
bokov_d_o@staff.sechenov.ru
DOI:
10.52711/0974-360X.2024.00717 
Address:
Prostodusheva T.V.1, Kiselevskii M.V.2, Bokov D.O.1,3*, Zaichikova S.G.1, Antsyshkina A.M.1, Bobkova N.V.1, Strelyaeva A.V.1, Konovalchik D.A.1, Rodin M.N.1, Shalburova S.G.S.1
1A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., Bldg. 2, Moscow, 119991, Russian Federation.
2Laboratory of Cell-Mediated Immunity, Blokhin National Medical Research Center of Oncology, 24, Kashirskoye Sh., Moscow, 115478, Russian Federation.
3Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky Pr., Moscow, 109240, Russian Federation.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
The effect of theblack medick (Medicago lupulina L.) herbextraction cytotoxic activity of healthy donors and cancer patients’ lymphocytes was studied. It was established that the extraction of M. lupulina has a direct cytotoxic effect on tumor cells and activates the antitumor activity of natural killers by interleukin – 2up-regulation. Theextraction of M. lupulina has a direct cytotoxic effect on the line of K-562 human tumor cells in a concentration not lower than 5mg/ml; Increases the cytotoxicity of lymphocytes in healthy donors and oncological patients against K-562 tumor cells in a concentration of at least 1.0mg/ml by 18% and by 23% accordingly. At the same concentration, it causes a reliable increase of 12% in the level of interleukin-2 in healthy donors and of 17% in oncological patients without effect of on the level of interleukin-1. The mechanism of M. lupulina activation influence on the cellular link of antitumor immunity can be related to the ability of biologically active substances isolated from alfalfa hops to stimulate release of regular cytokines from lymphocytes, inter alia, IL-2.M. lupulina herb can be used to create effective and low-toxic preventive medicines containing flavonoids. Natural flavonoids have a more selective and mild effect.The effect of the M. lupulina extracton cytotoxic activity of healthy donors and cancer patients lymphocytes was studied. It was established that the M. lupulina extract on has a direct cytotoxic effect on tumor cells and activates the antitumor activity of natural killers by interleukin – 2up-regulation.
Cite this article:
Prostodusheva T.V., Kiselevskii M.V., Bokov D.O., Zaichikova S.G., Antsyshkina A.M., Bobkova N.V., Strelyaeva A.V., Konovalchik D.A., Rodin M.N., Shalburova S.G.S.. The Black Medick (Medicago lupulina L.) extraction Cytotoxic activity. Research Journal of Pharmacy and Technology. 2024; 17(10):4658-2. doi: 10.52711/0974-360X.2024.00717
Cite(Electronic):
Prostodusheva T.V., Kiselevskii M.V., Bokov D.O., Zaichikova S.G., Antsyshkina A.M., Bobkova N.V., Strelyaeva A.V., Konovalchik D.A., Rodin M.N., Shalburova S.G.S.. The Black Medick (Medicago lupulina L.) extraction Cytotoxic activity. Research Journal of Pharmacy and Technology. 2024; 17(10):4658-2. doi: 10.52711/0974-360X.2024.00717 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-2
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