Author(s):
Munira Munira, Rasidah Rasidah, Muhammad Nasir
Email(s):
munira.bio@poltekkesaceh.ac.id
DOI:
10.52711/0974-360X.2024.00739 
Address:
Munira Munira*, Rasidah Rasidah, Muhammad Nasir
1Department of Pharmacy, Aceh Health Polytechnics, Banda Aceh, (Aceh) Indonesia.
2Department of Biology, Faculty of Mathematics and Natural Science, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, (Aceh) Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
Anti-bacterial creams containing herbs and natural products are important because they provide a safe and effective alternative to chemical-based products. C. odorata leaf extract contains numerous active chemicals that can be used to formulate antibacterial cream for topical application. This study aims to formulate an antibacterial topical cream containing active chemicals extracted from C.odorata leaf originating from geothermal area, and evaluate physicochemical properties of the formulated topical cream followed by in-vitro antibacterial activity of the formula. The C.odorata leaf extraction was performed by cold extraction using ethanol and its chemical contents was investigated using GC-MS followed by predicted bioactivity profile using a computer software. Physicochemical evaluation performed include organoleptic evaluation, spread ability, pH values, viscosity measurement, and homogeneity test. GC-MS spectra indicates that the ethanolic extract of C.odorata leaf contains 22 compounds dominated by alcohol derivative compounds and terpenoids where most compounds shows bioactivities when simulated using a computer program. The formulated cream corresponds to the standard of topical cream with good physical stability, homogeneity, and viscosity. The pH of the cream was found to be stable over 28 days after formulation. The antibacterial test against S. aureus indicated that the cream is active to inhibit the bacteria where F3 shows better results compared to other formulations and the positive control. The C.odorata leaf extract formulated as topical cream have shown great activity against S.aureus at the concentration of 10% due to various chemical contents including alcohol derivatives and terpenoids.
Cite this article:
Munira Munira, Rasidah Rasidah, Muhammad Nasir. Formulation and Antibacterial Essay of Topical Cream Enriched with (Chromolaena odorata) Leaf Extract Originating from Ie Seuem Geothermal Area, District of Aceh Besar, Indonesia. Research Journal of Pharmacy and Technology. 2024; 17(10):4803-0. doi: 10.52711/0974-360X.2024.00739
Cite(Electronic):
Munira Munira, Rasidah Rasidah, Muhammad Nasir. Formulation and Antibacterial Essay of Topical Cream Enriched with (Chromolaena odorata) Leaf Extract Originating from Ie Seuem Geothermal Area, District of Aceh Besar, Indonesia. Research Journal of Pharmacy and Technology. 2024; 17(10):4803-0. doi: 10.52711/0974-360X.2024.00739 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-24
REFERENCES:
1. Vijayaraghavan K, Rajkumar J, Bukhari SNA, Al-Sayed B, Seyed MA. Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review). Mol Med Rep. 2017; 15(3): 1007-1016. doi:10.3892/mmr.2017.6133
2. Owolabi MS, Ogundajo A, Yusuf KO, et al. Chemical composition and bioactivity of the essential oil of Chromolaena odorata from Nigeria. Records of Natural Products. 2010; 4(1): 72-78.
3. Putri DA, Fatmawati S. A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves. Evidence-based Complementary and Alternative Medicine. 2019; 2019(2017). doi:10.1155/2019/1453612
4. Yaouba A, Nnomo EK, Ze Medjap AS, Essola Etoa LC. Antibacterial effect of Chromolaena odorata extracts on some Erwinia isolates, causal agents of tomato fruit rot in Dschang, Cameroon. Agric Food Secur. 2017; 6(1): 4-9. doi:10.1186/s40066-017-0132-6
5. S Y, A M. Evaluation of Antidepressant Effect of Ethanol Extract and Chloroform Fraction of Moringa oleifera Lam. (Moringaceae) Leaf in Mice. Journal of Drug Research and Development. 2018; 4(1): 1-6. doi:10.16966/2470-1009.140
6. Thi Hong Hanh T, Thi Thuy Hang D, Van Minh C, Tien Dat N. Anti-Inflammatory Effects of Fatty Acids Isolated from Chromolaena Odorata Asian Pacific Journal of Tropical Medicine Chromolaena Odorata Asteraceae Fatty Acid Nitric Oxide.; 2011. www.elsevier.com/locate/apjtm
7. Gani BA, Soraya C, Sugiaman VK, et al. Fungistatic effect of Moringa oleifera Lam. on the metabolism changes of Candida albicans. J Pharm Pharmacogn Res. 2023; 11(1): 179-190. doi:10.56499/jppres22.1533_11.1.179
8. Sopandani P, Iskandar BO, Ariwibowo T, Djamil MS. Antibacterial Effects of Moringa oleifera Leaf Extract against Enterococcus faecalis in vitrio. Scientific Dental Journal. 2020;4(1):16-20. doi:10.4103/SDJ.SDJ
9. Anderson JL, Harrison DC, Meffin PJ, Winkle RA. Antiarrhythmic Drugs: Clinical Pharmacology and Therapeutic Uses. Drugs. 1978; 15(4): 271-309. doi:10.2165/00003495-197815040-00003
10. Kwon Y. Handbook of Essential Pharmacokinetics, Pharmacodynamic, and Drug Metabolism for Industrial Scientists. Kluwer Academic Publishers; 2001.
11. S. Valarmathi, M. Senthil Kumar, Vignesh Sharma, Mohamed Imran, Mohanasundaram. Formulation and Evaluation of Herbal Face Cream. Research J. Pharm. and Tech. 2020; 13(1):216-218.
12. O’Farrell C, Hall TJ, Grover LM, Cox SC. Formulation of an antibacterial topical cream containing bioengineered honey that generates reactive oxygen species. Biomaterials Advances. 2022;133(September 2021: 112664. doi:10.1016/j.msec.2022.112664
13. Munira M, Rasidah, Zakiah N, Nasir M. Identification of chemical compounds and antibacterial activity test of kirinyuh leaf extract (Chromolaena odorata L.) from Ie Seum geothermal area, regency of aceh besar, indonesia. Rasayan Journal of Chemistry. 2022; 15(4): 2852-2857. doi:10.31788/RJC.2022.1548031
14. Lin H, Zhu H, Tan J, et al. Comparative Analysis of Chemical Constituents of Moringa oleifera Leaves from China and India by Ultra-Performance Liquid Chromatography Coupled with Quadrupole-Time-Of-Flight Mass Spectrometry. Molecules. 2019;24(5). doi:10.3390/molecules24050942
15. Singh HP, Mishra SS, Sharma CS, Kumar N. Computational Analysis of Pharmacokinetic , Bioactivity and Toxicity Parameters of Some Selected Antihypertensive Agents. International Journal of Pharmaceutical Technology and Biotechnology. 2017; 4(June): 10-16.
16. Niranjan MK, Baghel K, Azam Z. Chitosan based bionanocomposites in osteoporosis. Bionanocomposites in Tissue Engineering and Regenerative Medicine. Published online 2021: 243-266. doi:10.1016/B978-0-12-821280-6.00014-3
17. LeGeros RZ. Calcium phosphate-based osteoinductive materials. Chem Rev. 2008; 108(11): 4742-4753. doi:10.1021/cr800427g
18. Schuchardt U, Sercheli R, Vargas RM. Transesterification of Vegetable Oils: A Review.; 1998.
19. Moazeni F, Chen Y chih, Zhang G. Enzymatic Transesteri Fi Cation for Biodiesel Production from Used Cooking Oil, a Review. Vol 216. Elsevier Ltd; 2019. doi:10.1016/j.jclepro.2019.01.181
20. Kaushita Banerjee, Diana Pearline, Nandita Kamat, Narayanaswamy Thiagarajan, Padma Thiagarajan. A green Hibiscus cannabinus oil emollient cream for potential topical applications. Research J. Pharm. and Tech. 2016; 9(6):735-740.
21. Jespersen ND, Brady JE, Hyslop A. Chemistry The Molecular Nature of Matter. 6th ed. John Wiley & Sons; 2012.
22. Sanjib Bahadur, Amit Roy, Ranabir Chanda, Pragya Baghel, Suman Saha, Ananta Choudhury. Extraction and Evaluation of some Phytochemcial and Physicochemical properties of Hibiscus rosasinensis mucilage. Res. J. Pharmacognosy and Phytochem. 2016; 8(4): 205-208.
23. OG Bhusnure, KR Alagawadi , PS Giram. Physicochemical Properties and Fatty Acid Composition in Lagerstroemia lanceolata Seed Oil. Research J. Pharmacology and Pharmacodynamics. 2010; 2(3): 252-254.
24. Rabindra K Nanda, Amol A Kulkarni, Meenal N Ranjane , Poonam N. Ranjane. A Stability-indicating HPTLC method for estimation of Nadifloxacin in topical cream. Res. J. Topical and Cosmetic Sci. 2010; 1(1): Jan. – June 25-29.
25. Trilokchandran. B, Vijayakumar G, Thippareddy K S. Formulation and Evaluation of Cosmetic Cream from Cabbage Extract. Research J. Pharm. and Tech. 2019; 12 (8): 3589-3594.
26. Amit Nikam, Chandrakant Magdum. Extraction, Preparation and Evaluation of Phyllanthus urinaria extract as Antifungal Cream. Asian Journal of Research in Chemistry. 2021; 14(5): 353-6.
27. Gopi C., Dhanaraju M. D.. Synthesis, Characterization and Anti-Microbial Evaluation of Derivative of Chalcone. Asian J. Research Chem. 2011; 4(2): February 181-182.
28. Abubakar I, Usman A. Phytochemical and antibacterial investigations of moringa (Moringa oleifera) leaf extract on selected bacterial pathogens. J Microbiol Antimicrob. 2016; 8(5): 28-33. doi:10.5897/jma2016.0361
29. T Raja Sekharan, M Syam Mohan, P Natarajan, A S William, Arputha Sundar A Thanga Thirupathi, R Venkatnarayanan. Wound Healing and Anti Bacterial Activity of the Leaves Extracts of Jasminum grandiflorum Linn. Research J. Pharmacology and Pharmacodynamics. 2010; 2(6): 388-391.
30. K. Hemalatha, D. Niranjan Raj, M. Fousia Begam, Sharanya. V.K., K. Girija. Synthesis, Characterization, Docking study and Anti-Bacterial Evaluation of Benzimidazole Derivatives as Biotin Carboxylase Inhibitors. Asian J. Pharm. Tech. 2017; 7(2): 109-114.