Author(s):
Suhas P. Padmane, Sharad R. Manapure, Jyotiram A. Sawale
Email(s):
jyotisawale@gmail.com
DOI:
10.52711/0974-360X.2024.00774 
Address:
Suhas P. Padmane1, Sharad R. Manapure1, Jyotiram A. Sawale2*
1Gurunanak College of Pharmacy, Mauza-Nari, Near Dixit Nagar, Kamptee Road, Nagpur - 440026, Maharashtra State, India.
2Department of Pharmacognosy, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Formerly Krishna Institute of Medical Sciences (Deemed to be University) Karad, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
The plant Amorphophallus campanulatus Roxb. is found predominantly all over India and is used for numerous ailments as well as for anti-inflammatory property as traditional medicine. In this study, we have done fractionation of sterol from chloroform and petroleum ether extracts and after fractionation the sterol fractions from petroleum ether (IC1), sterol fraction from chloroform extract (IC2), non-sterol fractions left after fractionation of chloroform extract (EX2) and petroleum ether extract (EX1) were subjected for anti-inflammatory study. In this experimental in vivo study, five groups were formed, consisting of albino rats weighing 200-250g, regardless of sex, each group comprised five animals. EX1, EX2, IC1, and IC2 extracts were given orally at a dose of 250mg/kg of body weight, 250mg/kg, 50mg/kg, and 50mg/kg respectively. The right hind paw was injected with 0.1ml of 1% carrageenan an hour later, and the paw volume was assessed one, three, and five hours later. Indomethacin was used as the reference standard. Sterol fractions (IC1 and IC2) showed significant anti-inflammatory activity at a dose 50mg/kg body weight compared with the indomethacin at 10mg/kg body weight; the non-sterol fraction did not demonstrate any anti-inflammatory property. When compared to indomethacin as a reference, it was determined that only the sterol fractions, IC1 and IC2, exhibited substantial anti-inflammatory effect. It demonstrates the strong anti-inflammatory property of A. campanulatus, which may be because of the presence of sterol.
Cite this article:
Suhas P. Padmane, Sharad R. Manapure, Jyotiram A. Sawale. Comparative Anti-inflammatory property of Sterol and Non-sterol Fractions from Amorphophallus campanulatus Roxb. tuber. Research Journal of Pharmacy and Technology. 2024; 17(10):5036-0. doi: 10.52711/0974-360X.2024.00774
Cite(Electronic):
Suhas P. Padmane, Sharad R. Manapure, Jyotiram A. Sawale. Comparative Anti-inflammatory property of Sterol and Non-sterol Fractions from Amorphophallus campanulatus Roxb. tuber. Research Journal of Pharmacy and Technology. 2024; 17(10):5036-0. doi: 10.52711/0974-360X.2024.00774 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-59
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