Author(s):
Moumita Kundu, Tapan Kumar Chatterjee, Dipanjan Mandal, Soumyarup Dutta, Tathagata Roy
Email(s):
tathagata.roy@nshm.com
DOI:
10.52711/0974-360X.2024.00781 
Address:
Moumita Kundu1, Tapan Kumar Chatterjee2, Dipanjan Mandal3, Soumyarup Dutta1, Tathagata Roy4*
1Assistant Professor, Department of Pharmacy, Anand College of Education, Kabilpur, Debra, West Bengal - 721126.
2Dean, Department of Pharmaceutical Technology, JIS University, Kolkata - 700109.
3Assistant Professor, Department of Pharmaceutical Technology, Gurunanak Institute of Pharmaceutical Science and Technology (GNIPST), Kolkata, West Bengal, India.
4Assistant Professor, Department of Pharmaceutical Technology, NSHM Knowledge Campus- Kolkata Group of Institutions, Kolkata, West Bengal, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
The purpose of this study was to formulate metformin microsphere in order to lessen its undesirable effects. To prepare metformin microspheres, the ionotropic gelation technique was used. In this process, two ionic components interact under specific circumstances. There needs to be a polymer in at least one of these two ionic components. Microspheres are formed by the simple interaction of an ionic polymer with an oppositely charged ion. In this procedure, the polymers employed were sodium alginate and chitosan; calcium chloride was used for the crosslinking process. Various parameters like particle size, Percentage yield, swelling index, Drug entrapment efficiency, Drug release study (In- vitro) and drug release kinetics studies were performed. From the experimental data it has been shown that chitosan and calcium chloride plays important role for variation of characteristic parameters of microspheres.
Cite this article:
Moumita Kundu, Tapan Kumar Chatterjee, Dipanjan Mandal, Soumyarup Dutta, Tathagata Roy. Preparation and Evaluation of Metformin Microspheres by Ionotropic Gelation Method. Research Journal of Pharmacy and Technology. 2024; 17(10):5079-4. doi: 10.52711/0974-360X.2024.00781
Cite(Electronic):
Moumita Kundu, Tapan Kumar Chatterjee, Dipanjan Mandal, Soumyarup Dutta, Tathagata Roy. Preparation and Evaluation of Metformin Microspheres by Ionotropic Gelation Method. Research Journal of Pharmacy and Technology. 2024; 17(10):5079-4. doi: 10.52711/0974-360X.2024.00781 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-66
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