Author(s): Job Herman Berkhout, Aswatha Ram H.N.


DOI: 10.52711/0974-360X.2024.00159   

Address: Job Herman Berkhout1, Aswatha Ram H.N.2*
1Faculty of Science, Radboud University, Nijmegen, the Netherlands.
2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024

The ionization state (pKa) of a compound influences its absorption, distribution, metabolism and excretion. Therefore, proper knowledge of the pKa is crucial in understanding the behavior of a compound behavior inside the body. In this research paper, we validate the pKa of muscarinic acetylcholine receptor antagonist atropine sulfate using Uv-Vis spectroscopy, to validate the use of this method and to re-evaluate the of atropine sulfate. The pKa value from absorption measurements is first estimated using 3rd degree polynomial and then precisely calculated according to the Albert-Sergeant method. We established that the pKa value of Atropine sulfate is 9.94±0.050 which is comparable to the values present in the literature.

Cite this article:
Job Herman Berkhout, Aswatha Ram H.N.. Research Journal of Pharmacy and Technology. 2024; 17(3):1029-2. doi: 10.52711/0974-360X.2024.00159

Job Herman Berkhout, Aswatha Ram H.N.. Research Journal of Pharmacy and Technology. 2024; 17(3):1029-2. doi: 10.52711/0974-360X.2024.00159   Available on:

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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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