Author(s): Raju Chiluka, Gaurav Maurya, Priyal Jangla, Dinesh Suthar, Roopam Raut

Email(s): roopam4pharma@gmail.com

DOI: 10.52711/0974-360X.2024.00160   

Address: Raju Chiluka, Gaurav Maurya, Priyal Jangla, Dinesh Suthar, Roopam Raut*
Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Colaba, Mumbai - 40005, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
The buccal drug delivery system is a versatile delivery system which can be designed for local or systemic effect. The objective of the study was to developed patient complacent tablet which can give sustain release of antibacterial agent for relief of upper respiratory tract infection. Azithromycin dihydrate is a semi-synthetic macrolide antibiotic widely used to prevent bacterial infections in the upper respiratory tract. The mucoadhesive buccal tablets of azithromycin dihydrate were formulated by varying concentrations of polymers (natural and synthetic), glidant and other excipients. The drug-excipient compatibility studies were carried out through DSC and FTIR studies. The selected excipients were found to be compatible. Further the dry blend of drug-excipients was evaluated for pre-compression properties. The prepared tablets were evaluated as per the general monograph for tablets of IP. The studies were also carried out to evaluate sustained release of the drug and mucoadhesivity of the tablets. A 23 level (2 level and 3 factors) factorial design was navigated to study the effect of natural, synthetic polymers and the glidant on mucoadhesive strength and percentage cumulative drug release at 8 hours. The responsive variables were analysed using ANOVA by Design-Expert version 12.0. It was concluded that these excipients significantly affected the response variables. The optimized tablet formulation was found to have an adequate mucoadhesion and a cumulative percentage release. The final product was performed for accelerated stability studies, optimized formulation was found to be stable at room temperature and accelerated temperature for three months.


Cite this article:
Raju Chiluka, Gaurav Maurya, Priyal Jangla, Dinesh Suthar, Roopam Raut. Mucoadhesive Buccal Tablet Formulation of Azithromycin dihydrate for treatment of Upper Respiratory Tract Infection. Research Journal of Pharmacy and Technology. 2024; 17(3):1033-9. doi: 10.52711/0974-360X.2024.00160

Cite(Electronic):
Raju Chiluka, Gaurav Maurya, Priyal Jangla, Dinesh Suthar, Roopam Raut. Mucoadhesive Buccal Tablet Formulation of Azithromycin dihydrate for treatment of Upper Respiratory Tract Infection. Research Journal of Pharmacy and Technology. 2024; 17(3):1033-9. doi: 10.52711/0974-360X.2024.00160   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-3-11


REFERENCES:
1.    Touitou E, Illum L. Nasal drug delivery. Drug Delivery and Translational Research. 2013; 3(1): 1-3.     https://doi.org/10.1007/s13346-012-0111-1.
2.    American Society of Health 4 System Pharmacists 2012; Drug Information. 2012. Bethesda, MD. 2012, p. 240
3.    Nagaveni P, Sirisha S, Rao CA. Formulation and evaluation of mucoadhesive buccal tablets of anti-diabetic drug using 23 factorial design. Asian Journal of Pharmacy and Technology. 2021;11(4):261-6.
4.    Li KL, Castillo AL. Formulation and evaluation of a mucoadhesive buccal tablet of mefenamic acid. Brazilian Journal of Pharmaceutical Sciences. 2020; 56. https://doi.org/10.1590/s2175-97902019000418575.
5.    Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian Journal of Pharmaceutical Sciences. 2008; 70(1): 43. https://doi: 10.4103/0250-474X.40330
6.    Begum SK, Sura RS, Phanindra B, Kumar PP. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Captopril. Research Journal of Pharmaceutical Dosage Forms and Technology. 2019; 11(3): 164-8.
7.    Singh SK, Bothara SB, Singh S, Patel R, Dodia R. Formulation and Evaluation of Mucoadhesive Tablet: Influence of Some Hydrophilic Polymers on the Release Rate and In Vitro Evaluation. International Journal of Pharmaceutical Sciences and Nanotechnology. 2010; 3(3): 1111-21. https://doi.org/10.37285/ijpsn.2010.3.3.9
8.    Khazaal AA, Samein LH, Shehab MA. Preparation and in-vitro evaluation of zolmitriptan mucoadhesive buccal tablets. Research Journal of Pharmacy and Technology. 2012; 5(10): 9.
9.    Singh J, Deep P. A review article on mucoadhesive buccal drug delivery system. International Journal of Pharmaceutical Sciences and Research. 2013; 4(3): 916.
10.    Nagaveni P, Sirisha S, Rao CA. A Complete Review on Mucoadhesive Buccal Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2): 121-6.
11.    Balamurugan M, Saravanan VS, Ganesh P, Senthil SP, Hemalatha PV, Pandya S. Development and in-vitro evaluation of mucoadhesive buccal tablets of domperidone. Research Journal of Pharmacy and Technology. 2008; 1(4): 377-80.
12.    Amballa H, Kaluva N, Beri SG, Chinnala KM, Konda M. Formulation and characterization of eplerenone mucoadhesive buccal tablets. Research Journal of Pharmacy and Technology. 2021; 14(6):3097-103.
13.    Razzaq S, Hanif S, Syed MA, Iqbal J, Raza SA, Riaz H, Abid F. Development and evaluation of mucoadhesive buccal tablet containing metronidazole for the treatment of periodontitis and gingivitis. Pakistan Journal of Pharmaceutical Sciences. 2018; 31(5).
14.    Ramana MV, Nagda C, Himaja M. Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate. Indian Journal of Pharmaceutical Sciences. 2007;69(4):515.
15.    Koirala S, Nepal P, Ghimire G, Basnet R, Rawat I, Dahal A, Pandey J, Parajuli-Baral K. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac. Heliyon. 2021; 7(3): e06439. https://doi.org/10.1016/j.heliyon.2021.e06439.
16.    Shanker G, Kumar CK, Gonugunta CS, Kumar BV, Veerareddy PR. Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets. AAPS Pharmscitech. 2009; 10(2): 530-9.
17.    Dasari N, Vaddi H, Muvvala S. Formulation and evaluation of mucoadhesive buccal tablets of resperidone. Asian Journal of Pharmacy and Technology. 2022;12(1):13-9.
18.    Agarwal V, Mishra B. Design, development, and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Development and Industrial Pharmacy. 1999; 25(6): 701-9. https://doi.org/10.1081/DDC-100102229.
19.    Umarji B, Patil R, Birajdar R, Mysore S, Bilagi S, Audurti D. Formulation and in vitro evaluation of mucoadhesive buccal tablets of furosemide. World J. Pharm. Pharm. Sci. 2012; 1(3): 1041-63.
20.    Patil CC, Pawar VV, Karajgi SR, Kalyane NV. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Ondansetron Hydrochloride. Res J. Pharm. Tech. 2018 ; 11(2): 581-6.
21.    Saleem MA, Pange SS, Umair SA, Singh VK. Development and Evaluation of Mucoadhesive Buccal Tablets of Sumatriptan Succinate using Natural Gums. Research Journal of Pharmacy and Technology. 2011; 4(7): 1140-6.
22.    Manivannan R, Balasubramaniam A, Anand DC, Sandeep G, Rajkumar N. Formulation and in vitro evaluation of mucoadhesive buccal tablets of diltiazem hydrochloride. Res J Pharm Tech. 2008; 1(4): 478-80.
23.    Karki D, Kulkarni GS, Swamy S, Sheeba FR. Formulation and evaluation of mucoadhesive buccal tablets of curcumin and its bioavailability study. Research Journal of Pharmacy and Technology. 2017; 10(12): 4121-8.
24.    Shanker G, Kumar CK, Gonugunta CS, Kumar BV, Veerareddy PR. Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets. AAPS Pharmscitech. 2009; 10(2): 530-9. https://doi.org/10.1208/s12249-009-9241-2.
25.    Vaidya VM, Manwar JV, Mahajan NM, Sakarkar DM. Design and in vitro evaluation of mucoadhesive buccal tablets of terbutaline sulphate. Int J PharmTech Res. 2009; 1(3): 588-97.
26.    Bahri-Najafi R, Rezaei Z, Peykanpour M, Shabab L, Solooki R, Akbari P. Formulation of nicotine mucoadhesive tablet for smoking cessation and evaluation of its pharmaceutical’s properties. Advanced Biomedical Research. 2013; 2.
27.    Patel H, Srinatha A, Sridhar BK. External cross-linked mucoadhesive microbeads for prolonged drug release: development and in vitro characterization. Indian Journal of Pharmaceutical Sciences. 2014; 76(5): 437.


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