Author(s): Yuni Anggraeni, Nadya Firdausi, Ahmad Randy, Rizna Triana Dewi, Siska Andriana Kusumastuti., Yulvian Sani, Tri Yuliani, Melati Septiyanti, Marissa Angelina

Email(s): mari011@brin.go.id

DOI: 10.52711/0974-360X.2024.00214   

Address: Yuni Anggraeni1, Nadya Firdausi1, Ahmad Randy2, Rizna Triana Dewi2, Siska Andriana Kusumastuti.2, Yulvian Sani3, Tri Yuliani2, Melati Septiyanti4, Marissa Angelina2*
1Pharmacy Study Program, Faculty of Health Sciences, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Ciputat Timur, South Tangerang, 15412.
2Research Centre for Pharmaceutical Ingredients and Traditional Medicine,
National Research and Innovation Agency Republic of Indonesia BRIN, 452 Building, Serpong Indonesia 15413
3Research Centre for Biomedic, National Research and Innovation Agency Republic of Indonesia BRIN, Cibinong Indonesia 16915.
4Research Center for Chemistry, National Research and Innovation Agency Republic of Indonesia BRIN, 452 Building, Serpong Indonesia 15413.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
Propionibacterium acnes and Staphylococcus epidermidis are Gram-positive commensal bacteria on human skin that can turn opportunistic. In a previous study, Cassia alata L. leaves extract had shown antibacterial activity against Gram-positive bacteria. In this study, C. alata leaves extract is used as an active ingredient in a topical cream preparation. This study aimed to determine the stability and the antibacterial activity of C. alata leaves extract cream against P. acnes and S. epidermidis. We prepared topical cream containing 1.25%, 2.5%, and 5% of C. alata extract and evaluated their physical parameters. The prepared C. alata leaves extract cream had good physical characteristics, but there were underwent changes during the accelerated stability test. The antibacterial activity of the C. alata leaves extract cream was studied using the agar well diffusion method. The results showed that the variations of C. alata leaves extract affected the antibacterial activity against P. acnes and S. epidermidis. Cream containing 5% ethanolic extract of C. alata leaves had the highest antibacterial activity.


Cite this article:
Yuni Anggraeni, Nadya Firdausi, Ahmad Randy, Rizna Triana Dewi, Siska Andriana Kusumastuti., Yulvian Sani, Tri Yuliani, Melati Septiyanti, Marissa Angelina. Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis. Research Journal of Pharmacy and Technology. 2024; 17(3):1356-3. doi: 10.52711/0974-360X.2024.00214

Cite(Electronic):
Yuni Anggraeni, Nadya Firdausi, Ahmad Randy, Rizna Triana Dewi, Siska Andriana Kusumastuti., Yulvian Sani, Tri Yuliani, Melati Septiyanti, Marissa Angelina. Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis. Research Journal of Pharmacy and Technology. 2024; 17(3):1356-3. doi: 10.52711/0974-360X.2024.00214   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-3-65


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