Author(s): Vani S, Venkatesan N, Chandrasekar SB, Sreedhar C, Anil T Pawar


DOI: 10.52711/0974-360X.2024.00226   

Address: Vani S1,2, Venkatesan N1, Chandrasekar SB2, Sreedhar C3, Anil T Pawar4
1School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), SBV Campus, Pillaiyarkuppam, Pondicherry - 607402, India
2Drugs Testing Laboratory, Drugs Control Department, Government of Karnataka, Palace Road, Bangalore - 560001, Karnataka, India
3Karnataka College of Pharmacy, Hegde Nagar Main Road, Thirumenahalli Post, Bangalore - 560064, Karnataka, India
4School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune - 411038, Maharashtra, India
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024

Drug delivery system (DDS) is a collective term used for techniques that carry drugs into or throughout the body for administration and distribution of drug substances to the target cells, specific tissues or desired organs, to exert optimal effects. Among various routes of DDS, the transdermal drug delivery system (TDDS) forms an attractive approach compared to other routes of administration in terms of easy application, non-invasive, avoiding first pass metabolism, for systemic / local effect, directly reaches blood stream, target drug delivery, controlled release of the drug, easy termination of drug action by removing the patch, suitable for geriatric, paediatric subjects, unconscious patients, enhanced subject compliance and decreased side effects and inter and intra-patient variability as well. In this review, we focused on physiology of skin, routes of percutaneous absorption and types of TDDS, design, development and formulation approaches, basic elements, pharmacokinetics, factors affecting drug penetration, characterization and its evaluation. Significant discussion of their specific advantages, benefits especially in pain management, clinical considerations, general guidelines for using TDDS, market demand etc. This article also provides valuable literature for suitability of most of the Non-steroidal anti-inflammatory drugs (NSAIDs) for transdermal administration mainly due to their pharmacological aspects. In recent years, the scope of TDDS has increased in national as well as foreign market. Hence there are increased research activities from many pharma companies and research institutes for potential drug candidates for TDDS. The promising response of transdermal patches has spurred further research and development in this area. The global transdermal patch pipeline is overflowing, pointing to a bright future for these patches in the coming years. Therefore, TDDS may be the best alternative to oral formulations for effective treatment of inflammatory conditions.

Cite this article:
Vani S, Venkatesan N, Chandrasekar SB, Sreedhar C, Anil T Pawar. Perspectives on Transdermal Drug Delivery System: A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1425-1. doi: 10.52711/0974-360X.2024.00226

Vani S, Venkatesan N, Chandrasekar SB, Sreedhar C, Anil T Pawar. Perspectives on Transdermal Drug Delivery System: A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1425-1. doi: 10.52711/0974-360X.2024.00226   Available on:

1.    Donatella P, Piyush S, Massimo F, Mauro F. Drug delivery systems. Encyclopedia of Medical Devices and Instrumentation. 2009; 2(8): 437-95. doi:10.1002/0471732877.emd274
2.    John MW,Kewal KJ. Drug delivery systems. Methods in molecular biology. 2008;437:1-50.doi: 10.1007/978-1-59745-210-6_1   
3.    Prabhakar D, Sreekanth J, Jayaveera KN. Transdermal drug delivery patches: a review. Journal of Drug Delivery and Therapeutics. 2013; 3(4): 213-21.   
4.    Sanjay B, Bigail W, Brigitta B. Transdermal drug delivery in pain management. Advance Access publication. Continuing Education in Anaesthesia, Critical Care and Pain. 2011; 11(2): 39-43. doi:10.1093/bjaceaccp/mkq054
5.    Woo YJ. Mina K. Hye EC. Ki SK. Recent advances in transdermal drug delivery systems: a review. Biomaterials Research. 2021; 25(24): 1-15.
6.    Nidhi S. A brief review on transdermal patches. Organic and Medicinal Chemistry International Journal Review Article. 2018; 7(2): 58-62 . doi: 10.19080/OMCIJ.2018.07.555707
7.    Kuick R. Global transdermal patch market, dosage, price and clinical trials insight 2028. Advance Access publication. 2022.
8.    Mathews L. Roy A. Management of pain using transdermal patches – A review. Asian J Pharmaceutical Clin Res. 2016; 9(6): 32-5. doi:
9.    Durand C, Alhammad A, Willett KC. Practical considerations for optional transdermal drug delivery. Am J Health Syst Pharm. 2012; 69(2): 116-24. doi: 10.2146/ajhp110158.
10.    Yuji S, Kenji K. Transdermal drug delivery (TDD) in pathology and treatment. Integrated nano-biomechanics. Science direct, Edited by Takami Yamaguchi, Takuji Ishikawa and Yohsuke Imai. 2018.
11.    Rajesh M, Kishor D. A Review on Transdermal Drug Delivery System. Research J. Science and Tech. 2011; 3(5): 227-31.
12.    Sai VK, Saikrishna P. Effect of Casting Solvent and Polymer on Permeability of Glipizide through Rate Controlling Membrane for Transdermal Use. Research J. Science and Tech. 2011; 3(4): 180-3.
13.    Nandkumar R, Kadam MM, Rokade. Transdermal Drug Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(2): 125-9. doi: 10.52711/2231-5659.2023.00023
14.    Nagadev C, Durga SR, Venkatesh P, Hepcykalarani D, Prema R. A Review on Transdermal Drug Delivery Systems. Asian J. Res. Pharm. Sci. 2020; 10(2): 109-14. doi: 10.5958/2231-5659.2020.00021.1
15.    Washington C, Washington N. Drug delivery to the skin. In: Physiological Pharmaceutics, Biological Barriers to drug absorption. A John Wiley and Sons, Inc., Publication. Edited by Heather A.E. Benson, Adam C. Watkinson. 2012.
16.    Lisi DM. OTC Transdermal analgesic patches in pain management. US Pharm. 2019; 44(3): 15-21.
17.    Ismail H, Ravikumar, Narayanaswamy VB, Injamamul H, Mohibul H. Design and Evaluation of Transdermal Patches Containing Risperidone. Asian J. Res. Pharm. Sci. 2016; 6(4): 208-22. doi: 10.5958/2231-5659.2016.00030.8
18.    Mithun B, Tamizharasi S, Sivakumar T. Challenges Facing Transdermal Drug Delivery Systems: A Conceptual Approach. Research J. Science and Tech. 2012; 4(5): 213-19.
19.    Rakesh PP, Grishma P, Hitesh P, Ashok B. Formulation and Evaluation of Transdermal Patch of Aceclofenac. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 108-15.
20.    Nikhil P, Chetan P, Savan V, Prajapati ST, Patel CN. Recent Advances in Transdermal Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2): 113-19.
21.    Saikumar Y., Saikishore V., Pavani K., Sairam D.T. Sindhura A. Role of Penetration Enhancers in Transdermal Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 300-8.
22.    G. Vasavi, P. Naga Haritha, B. Chandrashekar. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3): 123-9. doi: 10.5958/2231-5659.2018.00021.8
23.    Dipen P, Sunita A, Chaudhary BP, Nikunj B.Transdermal drug delivery system: A review. The Pharma Innovation International Journal. 2012; 1(4): 66-75. Available at
24.    Michael NP, Yogeshvar NK, Michael H, Michael SR. Transdermal patches: history, development and pharmacology. Br J Pharmacol. 2015; 172(9): 2179-209. doi: 10.1111/bph.13059
25.    Lyn M, Richard S. Transdermal drug delivery: principles and opioid therapy, continuing education in anaesthesia critical care and pain. oxford Acadamic Journals. 2007; 7(5): 171-9.
26.    Manisha S,Shivakumar HN,Prajila A. Formulation and evaluation of transdermal patch of rabeprazole sodium. Journal of Reports in Pharmaceutical Sciences. 2021; 10(2): 240-6. doi: 10.4103/jrptps.JRPTPS_126_20
27.    Othman A. Al Hi, Haji MSK, Muhammad S, Mosab A, Shakeel I, Abdul H. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharm. 2019; 69(2): 197-215. doi: 10.2478/acph-2019-0016.
28.    Francesco C, Paola M, Antonella C, Leila, Stefania P, Luisa M. Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen. Eur J Pharm Biopharm. 2005; 60(1): 61-8. doi: 10.1016/j.ejpb.2005.02.001
29.    Khwaja S. Transdermal Patches. Pharmatutor. 2012.
30.    Haji MSK, Muhammad S, Mosab A, Shakeel I, Abdul H. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharmaceutica. 2018; 69(1): 1-19.
31.    Roy N, Agrawal M, Chaudhary S, Tirkey V, Dhwah A, Mishra N. Review article on permeation enhancers: a major breakthrough in drug delivery technology. Int J Pharmaceutical Sci and Res. 2017; 8(3): 1001–11. doi: 10.13040/IJPSR.0975-8232.8(3).1001-11
32.    Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Buhse LF. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eur J Pharm Biopharm. 2006; 64(1): 1-8. doi: 10.1016/j.ejpb.2006.03.009.
33.    Kathe K, Kathpolia H. Film forming systems for topical and transdermal drug delivery. Asian J Pharm Sci. 2017; 12(6): 487-97. doi: 10.1016/j.ajps.2017.07.004
34.    Pawan J, Anju J, Lalita D, Yashpal S, Rajiv S. A review on transdermal patches the pharma research, a journal, The Pharma Research. 2010; 3: 139-49.
35.    Farzaneh S, Beom SK. Recent advances in polymeric transdermal drug delivery systems. Journal of Controlled Release. 2022;(341):132-46.
36.    Madison K0C. Barrier function of the skin: “La Raison d’Etre” of the Epidermis. J Invest Dermatol. 2003; 121(2): 231–41. doi: 10.1046/j.1523-1747.2003.12359.x.
37.    Naga Sai D, Krishna Veni V, Chandrasekar SB, Bhavani B. Solid dispersion method for design of donepezil orodispersible tablets: formulation and characterization. Am J. Pharm Tech Res. 2019; 9(30): 1-11.
38.    Lokesh Prasad MS, Vani S, Chandrasekar SB, Hemavathi G, Gurunath kalaskar P, Mohan S. Formulation and evaluation of herbal formulations (ointment, cream, gel) containing Leucas aspera and Biophytum sensitivum. GJRA. 2022; 11(9): 1-3.
39.    Vani S, Chandrasekar SB, Joshi vijay G, Venkatesan N, Sreedhar C. Design, development and evaluation of orally disintegrating mini tablets (ODMTs) containing cefixime for paediatric use-a novel approach. AICHST. 2023; 1(1): 141.
40.    Prit L, Rishabh B, Piyush B. Transdermal Patches: Physiochemical and in-vitro evaluation methods. International Journal of Pharmaceutical Sciences and Research. 2015; 6(5): 1826-36. doi: 10.13040/IJPSR.0975-8232
41.    Shakya P, Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel relieves postherapeutic neuralgia. Ann Neurol. 1995; 37(2): 246-53. doi: 10.1002/ana.410370216
42.    Zeng C, Wei J, Persson MSM. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med. 2018; 52(10): 642-50. doi: 10.1136/bjsports-2017-098043

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