Author(s): Kedar Prasad Meena, Bishesar Kumar Sahu, Tripty Karri, Pradeep Samal, Sandeep Yadav, Divya Jaiswal


DOI: 10.52711/0974-360X.2024.00277   

Address: Kedar Prasad Meena*, Bishesar Kumar Sahu, Tripty Karri, Pradeep Samal, Sandeep Yadav, Divya Jaiswal
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur – 495009, C.G. India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024

The potential applications of nanoparticles as oral drug delivery systems for diabetes treatment are discussed in this research article. This paper discusses polymeric nanoparticles, polysaccharides, and polymeric nanoparticles in the oral administration of anti-diabetic drugs. Diabetes is a chronic metabolic disorder characterized by insulin deficiency. Diabetes treatments are numerous, and nanoparticles have several advantages. Several studies and research reports based on nanotechnological approaches in the formulation of anti-diabetic drugs have highlighted the fact that research in the formulation of nanodrugs improved diabetes-fighting strategies based on plausible molecular mechanisms of action of the drugs. Additionally, efforts have been made to determine the optimal drug concentration and time of exposure in order to recommend a scientifically validated drug dose response in the development of various therapeutic strategies for anti-diabetic drugs, various types of nanoparticles are available; polymeric nanoparticles are one of the most commonly used nanoparticles. Polymeric nanoparticles range in size from 10-1000 nm. Polymeric nanoparticles created by combining a drug and a polymer. The main advantages of polymeric nanoparticles are their ease of preparation, targeted delivery, dose minimization, and high therapeutic efficiency.

Cite this article:
Kedar Prasad Meena, Bishesar Kumar Sahu, Tripty Karri, Pradeep Samal, Sandeep Yadav, Divya Jaiswal. Development and Characterization Pioglitazone Hydrochloride Loaded Nanoparticle for Management of Diabetes Mellitus. Research Journal of Pharmacy and Technology.2024; 17(4):1748-2. doi: 10.52711/0974-360X.2024.00277

Kedar Prasad Meena, Bishesar Kumar Sahu, Tripty Karri, Pradeep Samal, Sandeep Yadav, Divya Jaiswal. Development and Characterization Pioglitazone Hydrochloride Loaded Nanoparticle for Management of Diabetes Mellitus. Research Journal of Pharmacy and Technology.2024; 17(4):1748-2. doi: 10.52711/0974-360X.2024.00277   Available on:

1.    Sonia TA, Sharma CP. An overview of natural polymers for oral insulin delivery. Drug Discov Today. 2012; 17:784-92.
2.    Ramesan RM, Sharma CP. Challenges and advances in nanoparticle-based oral insulin delivery. Expert Rev Med Devic. 2009; 6:665-76.
3.    World Health Organization. About diabetes, Archived from the original on 31 March 2014. Retrieved 4 April 2014.
4.    Ahmed AM. History of diabetes mellitus. Saudi Med J. 2002; 23(4): 373-378.
5.    Simos YV, Spyrou K, Patila M, Karouta N, Stamatis H, Gournis D, Dounousi E, Peschos D. Trends of nanotechnology in type 2 diabetes mellitus treatment. Asian Journal of Pharmaceutical Sciences. 2020;
6.    Maitra A, Abbas AK. Endocrine system. In: Kumar V, Fausto N, Abbas AK (eds). Robbins and Cotran Pathologic basis of disease. Philadelphia, Saunders 2005;7:1156-1226.
7.    Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus: present and future perspectives. Nature Reviews Endocrinology. 2011.
8.    Okur ME, Karantas ID, Siafaka PI. Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Medications and Future Perspectives. Acta Pharmaceutica Sciencia. 2017; 55: 60-82. doi: 10.23893/1307-2080.APS.0555
9.    Rao JP, Geckeler KE. Polymer nanoparticles: Preparation techniques and size-control parameters. Progress in Polymer Science. 2011; 36:887–913.
10.    Francis R, Joy N, Aparna EP, Vijayan R. Polymer grafted inorganic nanoparticles, preparation, properties, and applications: A review. Polym. Rev. 2014;54: 268–347.
11.    Ranjit K, Baquee AA. Nanoparticle: A review of preparation and characterization and application. IRJP. 2013; 4:48-52.
12.    Nagavarma BVN, Yadav HKS, Ayuz A, Vasudha L S, Shivakumar HG. Different technique for preparation of polymeric nanoparticles – A Review, Asian Journal of Pharmaceutical and Clinical Research. 2012;5:3:8: 1-8.
13.    Todaro B, Moscardini A, Luin S. Pioglitazone-Loaded PLGA Nanoparticles: Towards the Most Reliable Synthesis Method. International Journal of Molecular Sciences. 2022; 23:2522. 10.3390/ijms23052522
14.    Mohanraj VJ, Chen Y. Nanoparticles- a review. Tropical Journal of Pharmaceutical. 2006; 5:1:561-573.
15.    Canchi A, Khosa A, Singhvi G, Banerjee S, Dubey SK. Design and Characterization of Polymeric Nanoparticles of Pioglitazone Hydrochloride and Study the Effect of Formulation Variables using QbD Approach. Current Nanomaterials. 2017; 2: 162-168.
DOI: 10.2174/2405461503666180501115359
16.    Molepeeceres J, Guzman M, Abruturas M R, Chacon M, Berger L. Application of center composite design in preparation of Polycaprolactone Nanoparticles by solvent displacement method. Int J Pharm Sci. 1996; 85:2006-213.
17.    Meyer E, Heinzelmann H. Scannin force microscopy. In: Wiesendanger R, Guntherodt H J. Editors. Scanning tunneling microscopy II, Surface Science. New York: Springer Verlag 1992;99-149.
18.    Khachane KN, Bankar VH, Gaikwad PD, Pawar SP. Formulation, evaluation and optimization of sustained release drug delivery of trimetazidine dihydrochloride by full factorial design. Inventi Impact: Pharm Tech. 2012; 3: 205-211.
19.    Ghorab MM, Tag R, Salah S. Preparation and characterization of ofloxacin loaded biodegradable poly D, L-lactide nanoparticles: A factorial design study. Inventi Impact: Pharm Tech. 2012; 2: 121-128.
20.    Mullaicharam A R, Nanoparticle in drug deliver y system, International Journal of Nutrition, Pharmacology Neurological Disease. 2011;1:2 103-121.
21.    Cetin M, Atila A, Sahin S, Vural I. Preparation and characterization of metformin hydrochloride loaded-Eudragit RSPO and Eudragit RSPO/PLGA nanoparticles. Pharmaceutical Development and Technology, 2013; 18(3): 570–576. doi: 10.3109/10837450.2011.604783
22.    Muzib YI, Ramya E, Ambedkar YR. Formulation, Optimization and Pharmacodynamic Studies of Pioglitazone HCl Solid Lipid Nanoparticles. Journal of Pharmaceutical Research International. 2021; 33(46A): 329-341.doi: 10.9734/JPRI/2021/v33i46A32873
23.    Rojewska A, Karewicz A, Karnas K, Wolski K, Zajac M, Kaminski K, Szczubiałka K, Zapotoczny S, Nowakowska M. Pioglitazone- Loaded Nanostructured Hybrid Material for Skin Ulcer Treatment. Materials. 2020; 13: 2050; doi:10.3390/ma13092050
24.    Boddupalli BA, Masana P, Anisetti RN, Kallem SV, Madipoju B. Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine. Drug Invention Today. 2013; 5:212-215.
25.    Souto EB, Souto SB, Campos JR, Severino P, Pashirova TN, Zakharova LY, Silva AM, Durazzo A, Lucarini M, Izzo AA, Santini A. Nanoparticle Delivery Systems in the Treatment of Diabetes Complications. Molecules. 2019; 24:4209 doi:10.3390/molecules24234209
26.    Emin Cam M, Ertas B, Alenezi H, et al. Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents- loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study. Materials Science and Engineering. 2020;
27.    Tangri P, Bisht B. Who Role and Guidelines in Stability Study of Pharmaceuticals: A Regulatory Perspective. International Journal of Research in Pharmaceutical and Biomedical Science 2012;3(3).
28.    Kamela R, batanonyb RE, Salama A. Pioglitazone-loaded three-dimensional composite polymeric scaffolds: A proof of concept study in wounded diabetic rats. International Journal of Pharmaceutics. 2019; 570 :118667
29.    Ding Y, Cheng Y, Hao B, Zhu L, Zhang N, Zhao B, Tian Y. Metal–organic framework modifed by silver nanoparticles for SERS based determination of sildenafil and pioglitazone hydrochloride. Microchim Acta. 2021;188: 351 ttps://
30.    Shehata TM, Almostafa MM, Elsewedy HS. Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect. Polymers. 2022;14: 3021.
31.    Shalu Choudhary , unil. The Effect of Temperature and Pressure Dependent Viscosity on Thermal Convection in a Rotating Couple-Stress Fluid Saturating a Porous Medium: A Nonlinear Stability Analysis. Research J. Science and Tech. 2013; 5(1): 55-64.

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