Author(s): Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu

Email(s): dennysatria@usu.ac.id

DOI: 10.52711/0974-360X.2024.00325   

Address: Denny Satria1*, Debi Dinha Octora2, Mahatir Muhammad1, Rosidah3, Jansen Silalahi4, Syukur Berkat Waruwu5
1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
2Faculty of Pharmacy, Institut Kesehatan Medistra Lubuk Pakam, Deli Serdang, Indonesia.
3Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
5Faculty of Pharmacy and Health Sciences, Universitas Sari Mutiara Indonesia, Medan, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Hypercholesterolemia is strongly associated with elevated levels of total cholesterol, LDL cholesterol, triglycerides, and reduced HDL cholesterol levels. Disruption of the fat oxidation process can trigger fat accumulation in the liver. Liver disorders can be detected through an increase in liver enzymes, namely SGOT and SGPT, and an increase in the LDH enzyme, which can be used as a biomarker if there is damage to the liver or cell death, as well as increased ROS. ROS production causes a decrease in superoxide dismutase (SOD) activity. Saurauia vulcani Korth is a plant belonging to the Actinidiaceae family and commonly utilised in herbal medicine. Several studies show that Sauaria vulcani Korth has antihyperglycemic and antihyperlipidemic activity. This plant has several active ingredients, such as flavonoids, tannins, and saponins. Flavonoids can reduce total cholesterol levels, triglyceride levels and LDL levels. Extracts at doses of 50, 100, 200, 400 mg/KgBW with atorvastatin 0.80mg/KgBW were able to reduce levels of total cholesterol, LDL, triglycerides, SGOT, SGPT and increase HDL. At a dose of 200mg/KgBW, it can increase SOD and LDH levels. Ethanol extract of Saurauia vulcani Korth leaves has antihypercholesterolemic activity.


Cite this article:
Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu. In vivo Analysis of Saurauia vulcani Korth. Leaves Extract as Antihypercholesterolemic. Research Journal of Pharmacy and Technology. 2024; 17(5):2051-5. doi: 10.52711/0974-360X.2024.00325

Cite(Electronic):
Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu. In vivo Analysis of Saurauia vulcani Korth. Leaves Extract as Antihypercholesterolemic. Research Journal of Pharmacy and Technology. 2024; 17(5):2051-5. doi: 10.52711/0974-360X.2024.00325   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-21


REFERENCES:
1.    Mohibul Hoque, Satish S. Antihyperlipidemic activity in aqueous leaf extract of Ciceracida in Wistar Albino Rats. Res. J. Pharmacology and Pharmacodynamics. 2017; 9(3): 142-146. doi: 10.5958/2321-5836.2017.00024.6
2.    Shah Murad, Seema, A Ghaffar, G Mujtaba Abbasi, Ijaz Ur Rehman, Abdul Qadir. Abnormal Lipid Parameters and Herbs. Asian J. Pharm. Res. 2019; 9(3): 155-158. doi: 10.5958/2231-5691.2019.00024.8
3.    Sarvesh CN. Jennifer F. Suresh J. Yogesh HS. Shivakumar S. Antihyperlipidemic activity of Achyranthes aspera Linn leaves on cholesterol induced hyperlipidemia in rats. Research Journal of Pharmacy and Technology. 2017; 10(1): 201 – 204 doi:10.5958/0974-360X.2017.00043.9
4.    Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Chetashri N. Patil, Rohit D. Nalawade, Asawari P. Mansabdar. Hyperlipidaemia: A Review of Literature. Research Journal of Pharmacology and Pharmacodynamics. 2023; 15(3): 127-2. doi: 10.52711/2321-5836.2023.00023
5.    Olaiya, C. O.; Omolekan, T. O. Antihypercholesterolemic activity of ethanolic extract of Buchholzia coriacea in rats. African Health Sciences. 2013, 13.4: 1048-1090. doi: 10.4314/ahs.v13i4.32
6.    Rohit Gundamaraju Diana Vivian Atigari, DS Helen Sheeba, Ramesh C. Evaluation of anti-obesity activity of Lantana camara var Linn on butter induced Hyperlipidemia in Rats. Research J. Pharmacology and Pharmacodynamics. 2012; 4(5): 315-318.
7.    Rahul D. Shimpi, Shashikant D. Barhate, Mayur S. Jain. Bempedoic acid a novel drug used for the treatment of Hyperlipidaemia: A Review. Asian Journal of Pharmaceutical Research. 2023; 13(1):68-0. doi: 10.52711/2231-5691.2023.00013
8.    Ravindra Babu. S, Priyanka Goud. K. Evaluation of Anti-Hyperlipidemic and Anti Oxidant Activity of Ethanolic Extract of Delonix Elata on High fat diet Induced Rats. Res. J. Pharmacognosy and Phytochem. 2018; 10(3): 241-245. doi: 10.5958/0975-4385.2018.00039.0
9.    Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas Root Extract on Lipid Peroxidation. Research J. Pharm. and Tech. 2010; 3(4): 1072-1076.
10.    Nitin Mahurkar, S.M Sayeed ul hasan, S. Mutaal Quadri. Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia. Res. J. Pharm. Dosage Form. and Tech. 2015; 7(1): 11-14. doi: 10.5958/0975-4377.2015.00003.8
11.    Sampada S. Sawant, Vishal R. Randive, Savita R. Kulkarni. Lectins from seeds of Abrus precatorius: Evaluation of Antidiabetic and Antihyperlipidemic Potential in Diabetic Rats. Asian J. Pharm. Res. 2017; 7(2): 71-80. doi: 10.5958/2231-5691.2017.00013.2
12.    Schiffrin EL. Oxidative stress, nitric oxide synthase and superoxide dismutase a matter of imbalanceunderlies endhthelial dysfunction in the humancoronary circulation. Hypertension, 2008; 51:31-3. https://doi.org/10.1161/HYPERTENSIONAHA.107.103226
13.    Barakat, Hassan; Almundarij, Tariq I. Phenolic compounds and hepatoprotective potential of Anastatica hierochuntica ethanolic and aqueous extracts against CCl4-induced hepatotoxicity in rats. Journal of Traditional Chinese Medicine. 2020; 40(6): 947.
14.    Feng, Xin-Hong, et al. In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit. Phytomedicine. 2021; 83: 153479. https://doi.org/10.1016/j.phymed.2021.153479
15.    Preeti Tiwari and Rakesh K. Patel Evaluation of Antihyperlipidemic Potential of Drakshasava Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research J. Pharmacology and Pharmacodynamics. 2013; 5(2): 92-97.
16.    Sitorus P. Characterization Simplisia and Ethanolic Extract of Pirdot (Saurauia Vulcani, Korth) Leaves and Study of Antidiabetic Effect in Alloxan Induced Diabetic Mice. Int. J. ChemTech Res, 2015; 8(6): 789-794.
17.    Sitorus P. Rosidah, dan Satria D. Hypoglycemic activity of ethanolic extract of Saurauia vulcani Korth. Leaves. Asian J Pharm Clin Res, 2018; 11(1): 35-36.
18.    Khyati B. Rohit, Gunvant H. Yeola, Kalyani P. Nishane, Amol H. Waghmare, D. G. Dipankar. Clinical Evaluation of efficacy of Rasarakta pachak Ghanavati in Hyperlipidaemia (Rasagat sneha vriddhi). Research Journal of Pharmacy and Technology. 2022; 15(3): 971-5. doi: 10.52711/0974-360X.2022.00162
19.    Hutahaean S, Tanjung M, Sari DP and Ningsih VE. Antihyperglycemic and Antihyperlipidemic Effects of Pirdot (Saurauia vulcani Korth.) Leaves Extract in Mice. IOP Conf. Series: Earth and Environmental Science. 2018; 130: 1-7. doi:10.1088/1755-1315/130/1/012042
20.    Satria D, Silalahi J, Haro G, Ilyas S, Hsb PA. Antioxidant and Antiproliferative Activities of an Ethylacetate Fraction of Picria Fel-Terrae Lour. Herbs. Asian Pac J Cancer Prev. 2017 Feb 1; 18(2): 399-403. doi: 10.22034/APJCP.2017.18.2.399
21.    Margata, L, Sialahi, J, Harahap, U, Satria, D. The Effect of Hydrolyzed Virgin Coconut Oil on Lipid Profile and Liver Enzymes in Dyslipidemic Rats. Asian J Pharm Clin Res. 2018; 11(10).
22.    Hassan S, El-Twab SA, Hetta M, Mahmoud B. Improvement of lipid profile and antioxidant of hypercholesterolemic albino rats by polysaccharides extracted from the green alga Ulva lactuca linnaeus. Saudi J Biol Sci. 2011; 18: 333-40. https://doi.org/10.1016/j.sjbs.2011.01.005
23.    Hall IH. In: Paoletti R, Kritchevsky D, Holmes WL, editors. Drugs Affecting Lipid Metabolism. Berlin: Springer. 1987: p. 451.
24.    Reddy NV, Raj P, Raju G, Anarthe SJ. Antihyperlipidemic activity of Cassia fistula bark using high fat diet induced hyperlipidemia. Int J Pharm Pharm Sci, 2015; 7:61-4.
25.    Weydert, C., Cullen, J. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. 2010; 5: 51–66 https://doi.org/10.1038/nprot.2009.197
26.    Hinneburg I, Dorman HD, Hiltunen R. Antioxidant activities of extracts from selected culinary herbs and spices. Food chemistry. 2006; 97(1): 122-9. https://doi.org/10.1016/j.foodchem.2005.03.028
27.    G Shobana, G Sivaelango, P. Kumaravel. Evaluation of antihyperlipidaemic effect of Macrotyloma uniflorum seed extract in experimental hyperlipidaemia. Research J. Pharm. and Tech. 2012; 5(3): 353-356.
28.    Joni T, Rama D, Purwaningsih, Hadi K. Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic. Research Journal of Pharmacy and Technology. 2019; 12(6): 2936–2942. doi:10.5958/0974-360X.2019.00494.3
29.    Yelaware Puttaswamy N, Urooj A. In Vivo Antihypercholesterolemic Potential of Swietenia mahagoni Leaf Extract. Cholesterol. 2016; 2016: 2048341. doi: 10.1155/2016/2048341
30.    Rasha H, Al R, Hanady S, Al S. Evaluation of Hesperidin Protective Effect on Lipopolysaccharide -Induced Inflammation and lipid Peroxidation in BALB/C Mail Mice. Research Journal of Pharmacy and Technology. 2018; 11(12): 5513–5516. 10.5958/0974-360X.2018.01003.X
31.    Muflikhatur SR, Dan Murwani HR. Perbedaan Pengaruh Antara Ekstrak dan Rebusan Daun Salam (Eugenia polyantha) Dalam Pencegahan Peningkatan Kadar Kolesterol Total Pada Tikus Spraque Dawley. Journal of Nutrion College. 2014; 3(1): 148.
32.    Thilakavathu A, Arjun P, Samiraj R. Hypocholesterolemic Effect of Dietary Fish Oil in Albino Wistar Rats. Research Journal of Pharmacy and Technology. 2019; 12(9): 4161 – 4164. DOI:10.5958/0974-360X.2019.00718.2
33.    Amany MM, Tawfik MF, Hikal MS, Tag ED. Hypocholesterolemic Effect of Saponin Extracts in Experimental Animals. Arab Universities Journal of Agricultural Sciences, 2019; 26(6): 2463 – 2478.
34.    Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic Effects of Plant Flavonoids. BioMed Research International. 2014; (11): 1–3. https://doi.org/10.1155/2014/480258
35.    Morakinyo AO, Iranloye BO, Oyelowo OT, Nnaji J. The mechanism of increasing the enzymes SGOT and SGPT are caused by the inclusion of excess toxic substances into the body that will be metabolized by the enzyme cytochrome P450 in the liver into free radicals. Biology and Medicine. 2012; 4(3): 134– 140.
36.    Afrose S, Hossain S, Salma U, Miah AG, Tsuji H. Dietary Karaya Saponin and Rhodobacter Capsulatus Exert Hypocholesterolemic Effects by Suppresion of Hepatic Cholesterol Synthesis and Promotion of Bile Acid Syntesis in Laying Hens. Journal Hindawi Publishing Corporation. 2010; 10(7): 1-6. https://doi.org/10.1155/2010/272731
37.    Prasannakumar BR, Mohammed K, Shankar P. Hepatoprotective activity of Momordicia diocia Roxb fruits in Carbon tetrachloride induced hepatotoxic Rats. Research Journal of Pharmacy and Technology. 2009; 2(1): 114 – 116.
38.    Adwas AA, Elsayed ASI, Azab AE, et al. Oxidative stress and antioxidant mechanisms in human body. J Appl Biotechnol Bioeng. 2019; 6(1): 43‒47. DOI: 10.15406/jabb.2019.06.00173
39.    Kandasamy SC, Mohammed BE, Shimna TPS, Kumar RS, Gopal V, Venkatnarayanan R. Hepatoprotective Activity of Polyherbal Formulation Containing Some Indigenous Medicinal Plants in Rats. Research Journal of Pharmacy and Technology. 2010; 3(3): 828 – 831.
40.    Byahatti VV, Khan AM, Patil SH, Choudhury A. Preliminary Phytochemical Investigation and In-vitro Antioxidant Activity of Bergenia ciliata Leaves. Research Journal of Pharmacy and Technology. 2010; 3(2): 399 – 401.
41.    Tan BL, Norhaizan ME, Liew WP, Rahman HS. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. 2018; (9): 1162. https://doi.org/10.3389/fphar.2018.01162
42.    Himesh S, Govind N, Kaushelendra M, Singhai AK, Pathak AK. Evaluation of Phyto Pharmaceutical and Antioxidant Potential of Methanolic Extract of Peel of Punica granatum. Research Journal of Pharmacy and Technology. 2010; 3(4): 1170 – 1174.
43.    Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative Stress and Antioxidant Defense. World Allergy Organization Journal. 2012. 5(1): 9–19. https://doi.org/10.1097/WOX.0b013e3182439613
44.    Jothy SL, Aziz A, Chend Y, Sasidharan S. Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury. Evidence-based Complementary and Alternative Medicine. 2012; 4 – 5. https://doi.org/10.1155/2012/561284
45.    Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS. Role of Antioxidants and Natural Products in Inflammation. Oxidative Medicine and Cellular Longevity. 2016; 6 -8. https://doi.org/10.1155/2016/5276130
46.    Pieta PG. Flavonoids as Antioxidants. J. Nat. Prod, 2000; 63: 1043-1046. Prooxidant Activities of Antioxidants and Their Impact on Health. Acta Clinica Croatica. 2019; 58(4): 726 – 736. https://doi.org/10.1021/np9904509
47.    Berger MM. Can Oxidative Damage be Treated Nutritionally. Clinical Nutrition. 2005; (24): 172-178. https://doi.org/10.1016/j.clnu.2004.10.003



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