Author(s): Andrew Gnanaprakasam J, Veeramani G

Email(s): veer9282@gmail.com

DOI: 10.52711/0974-360X.2024.00332   

Address: Andrew Gnanaprakasam J, Veeramani G*
Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India, 608002.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Objective: The purpose of the study is to observe the metformin associated effects on Vitamin B12 among Type II Diabetes mellitus patients. Methods: An observational study conducted over the period of 12 months on Type II Diabetes mellitus patients who are in the chronic therapy of metformin. The study described about the Vitamin B12 levels among the Type II DM patients which was able to alert the patients who are in the low and border range of Vitamin B12 to prevent the risk of peripheral neuropathic complications. Findings: Totally 102 patients were enrolled as per the inclusion and exclusion criteria, during the study total 61 males (59.8%) and 41 females (40.2%) were enrolled. Among them 12 patients (mean 49.16±S.D10.53) on low level of the Vitamin B12 followed by 16 patients (mean 51.95±S.D7.12) found to above the normal range of the Vitamin B12 followed by 30 (mean 57.53±S.D4.55) patients found to borderline of the Vitamin B12. Conclusion: High doses with chronic therapy of Metformin may alter Vitamin B12 level. Some of the patients had been observed abnormal level of higher value of Vitamin B12. In such Patients’ diet history also had some impact on Vitamin B12. However, the high chances of metformin associated effect on Vitamin B12 with higher doses of metformin with long term therapy. Moreover, age also important fact that the study reveals among gender, male population had higher rate of low level Vitamin B12 than female population. Moreover, Patients age group between 50 and 65(male58 ± 3.58, female 57.16±3.81) were having higher rate of low level Vitamin B12 than other age group. Patients with other comorbid condition also had low level and borderline of Vitamin B12 those who were on long term therapy of metformin. Therefore, our study concluding that chronic therapy of metformin may lead to deficit in serum Vitamin B12 which required regular check on Vitamin B12 among Type 2 DM patients to avoid the risk of Peripheral neuropathy and other complications.


Cite this article:
Andrew Gnanaprakasam J, Veeramani G. Metformin Therapy and its associated effects of serum Vitamin B12 among Type II Diabetes Mellitus patients. Research Journal of Pharmacy and Technology. 2024; 17(5):2099-2. doi: 10.52711/0974-360X.2024.00332

Cite(Electronic):
Andrew Gnanaprakasam J, Veeramani G. Metformin Therapy and its associated effects of serum Vitamin B12 among Type II Diabetes Mellitus patients. Research Journal of Pharmacy and Technology. 2024; 17(5):2099-2. doi: 10.52711/0974-360X.2024.00332   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-28


REFERENCE:
1.    P. Maheshwari, T. S. Shanmugarajan. Evaluation of Prescribing Practices of Metformin in Patients with Type-2 Diabetes Mellitus. Research J. Pharm. and Tech. 2019; 12(2):531-534.
2.    Suraj B, C D Tripathi, Krishna Biswas, B M Padhy, Tarun Arora. Research J. Pharm. and Tech. 2015; 8(1): 44-50.
3.    U. S. Mahadeva Rao, Thant Zin, Kyi Kyi Win RN, Subbhagganthan A/L Subramaniam, Tan Bin Shan, Kaushilya A/P Mogan, Anis Syafiqah Binti Ismail. Cross-Sectional Study on Knowledge, Attitude and Practice regarding Diabetes mellitus among Medical and Non-Medical Students. Research J. Pharm. and Tech 2018; 11(11): 4837-4841. doi: 10.5958/0974-360X.2018.00879.X.
4.    S. Preethikaa, M. P. Brundha. Awareness of Diabetes Mellitus among General Population. Research J. Pharm. and Tech 2018; 11(5):1825-1829 doi: 10.5958/0974-360X.2018.00339.6.
5.    Liu KW, Dai LK, Jean W. Metformin related Vitamin B12 deficiency. Age and Ageing. 2006; 35(2): 200-201.
6.    Toh SY, Zarshenas N, Jorgensen J. Prevalence of nutrient deficiencies in bariatric patients. Nutrition. 2009; 25: 1150
7.    Andres E, Noel E, Goichot B. Metformin associated Vitamin B12 deficiency. Arch Intern Med. 2002; 162: 2251-2252.
8.    Gilligan MA. Metformin and Vitamin B12 deficiency. Arch Intern Med. 2002; 162: 484-485.
9.    Bauman W, Shaw S, Jayatilleke E et al. Increased intake of calcium reverses Vitamin B12 malabsorption induced by metformin. J Intern Med. 2003; 254: 455-463.
10.    Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascula disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57
11.    Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998; 338: 1042-50.
12.    DeFronzo RA, Goodman AM and the Multicenter Metformin Study Group. Efficacy of metformin in patients with noninsulin-dependent diabetes mellitus. N Engl J Med. 1995; 333: 541–9.
13.    Berchtold P, Bolli P, Arbenz U, Keiser G. Intestinale Absorptionsstörung infolge Metforminbehandlung. Diabetologia. 1969; 5: 405–12
14.    Shaw S, Jayatilleke E, Bauman W, Herbert V. Mechanism of B12 malabsorption and depletion due to metformin discovered by using serial serum holo-transcobalamin II (holo TCII) (B12 on TCII) as a surrogate for serial Schilling tests. Blood. 1993; 82 (Suppl. 1): 432A.
15.    Adams JF, Clark JS, Ireland JT, Kesson CM, Watson WS. Malabsorption of Vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia. 1983; 24: 16–18.
16.    Sreejith K, Malarkodi Velraj. Association between Metformin and Cognitive impairment–A Review. Research J. Pharm. and Tech. 2020; 13(2):1055-1058.
17.    Sally Kaddoura, Marwan Alhalabi, Abdul Hakim Nattouf. The effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid profile in vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients. Research J. Pharm. and Tech. 2019; 12(4): 1610-1614.
18.    Sharma Priya, Malik Sujeeta. Knowledge on Management of Diabetes Mellitus among Patients with type II Diabetes Mellitus in a Selected Community Health Centre of Dadra and Nagar Haveli Area. Asian J. Nursing Education and Research. 2019; 9(1): 109-112.
19.    Jeeva S. , Molly Babu. Knowledge of Diabetic Clients Regarding Self-care Practices in Management of type II Diabetes Mellitus at selected Rural Community of Bangalore, Karnataka. Asian J. Nur. Edu. and Research. 2017; 7(1): 86-94.
20.    Gepsi Jain, Nahomi Clement. A Study to assess the knowledge regarding self management behaviour among Type II Diabetes Mellitus patients in prevention of COVID-19 at selected area, Alappuzha District, Kerala, India. Asian Journal of Nursing Education and Research. 2022; 12(4):449-3.
21.    Nithya. G, Beulah. G. Effectiveness of Structured Teaching Program on Knowledge and Self-Care Management on Type II Diabetes Mellitus among Alcoholic Males with Type II Diabetes Mellitus. International Journal of Advances in Nursing Management. 2022; 10(3):197-0.
22.    Jeeva. S, Molly Babu. Assessment of self-care Practices of Diabetic Clients Regarding Management of type II Diabetes Mellitus at Selected Urban area of Bangalore, Karnataka. Int. J. Nur. Edu. and Research. 2016; 4(4): 449-455.
23.    Sharma Priya, Malik Sujeeta. Effectiveness of Structured Teaching Programme on Fasting Blood Sugar among Patients with Type II Diabetes Mellitus in a selected Community Health Centre of Dadra and Nagar Haveli area. Int. J. Nur. Edu. and Research. 2019; 7(2): 170-172.
24.    Dayalal Patidar, Kaushal Patidar, Urmila Prajapati. A Study to assess the effectiveness of Planned teaching Programme on knowledge regarding Vitamin B12 deficiency among the people in selected Areas of Mehsana City. Int. J. Nur. Edu. and Research. 2021; 9(1): 88-90.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available