Author(s):
Savio Simon, Viji Krishnan, Lola Ramachandran
Email(s):
vijikrishnanpk@gmail.com
DOI:
10.52711/0974-360X.2024.00334 
Address:
Savio Simon1, Viji Krishnan2, Lola Ramachandran3
1Jubilee Mission Medical College and Research Institute, Thrissur, 680005, Kerala, India.
2Department of Biochemistry, Jubilee Mission Medical College and Research Institute, Thrissur, 680005, Kerala, India.
3Department of Obstetrics and Gynecology, Jubilee Mission Medical College and Research Institute, Thrissur, 680005, Kerala, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 5,
Year - 2024
ABSTRACT:
Background: Preeclampsia associated with serious maternal and fetal complications is considered an emergency. In women with preeclampsia, the level of lactate dehydrogenase (LDH), an intracellular enzyme, rises due to cell death. The aim of this study was to compare serum LDH levels and its relationship with maternal and infant outcomes in patients with mild and severe preeclampsia. Materials and Methods: This study was conducted in the Obstetrics and Gynecology department of a tertiary hospital between February 2021 and March 2021. Sixty pregnant women who were at least 28 weeks pregnant were included. Thirty healthy controls, including 15 mild preeclampsia and 15 severe preeclampsia. The study involved measuring blood levels of LDH in all 60 patients and assessing outcomes for mothers and babies based on these levels. Results: The study showed that LDH levels were elevated during preeclampsia (p=0.01). There is a positive correlation between patients with preeclampsia (p=0.05) Between systolic blood pressure and diastolic blood pressure and LDH level. Additionally, a significant correlation (p = 0.01) was found between high LDH levels and birth weight. This study also confirmed that high serum LDH is associated with an increased risk of maternal complications (p = 0.01). Conclusion: Measurement of LDH levels can be used as a biochemical marker to determine cell damage and therefore disease severity. Therefore, monitoring and management of patients with LDH can help prevent maternofetal problems.
Cite this article:
Savio Simon, Viji Krishnan, Lola Ramachandran. A Hospital-based Study on assessing the significance of Serum Lactate dehydrogenase level in Preeclampsia and its association with Maternal and Fetal outcome. Research Journal of Pharmacy and Technology. 2024; 17(5):2109-3. doi: 10.52711/0974-360X.2024.00334
Cite(Electronic):
Savio Simon, Viji Krishnan, Lola Ramachandran. A Hospital-based Study on assessing the significance of Serum Lactate dehydrogenase level in Preeclampsia and its association with Maternal and Fetal outcome. Research Journal of Pharmacy and Technology. 2024; 17(5):2109-3. doi: 10.52711/0974-360X.2024.00334 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-30
REFERENCES:
1. Prathima. P, S. Anuchitra. Compliance on Antenatal Care advices Among Antenatal Mothers with Pregnancy induced Hypertension in selected Hospital Bangalore. Intenational Journal of Advances in Nursing Management. 2(4): Oct. - Dec., 2014; p196-199.
2. Cunningham, F.G., Leveno, K.J., Bloom, S.L,et al .William obstetrics.New York: McGraw-Hill; 2010. 23rded :p. 706-756
3. Meenakshi Sharma, Vibha, Asha. A Quasi experimental study to assess the effectiveness of music therapy on stress and blood pressure among antenatal mothers with Pregnancy Induced Hypertension at selected hospitals of Punjab. Intenational Journal of Advances in Nursing Management. 2016; 4(4): 355-360. doi: 10.5958/2454-2652.2016.00079.2
4. Preethi Jazna.B, Reeta Jebakumari, Nalini Jeyavantha Santha. A Study to Assess the Effectiveness of Benson Relaxation Therapy on Blood Pressure and Stress among Women with Pregnancy Induced Hypertension in Selected Hospitals, Madurai. Asian Journal of Nursing Education and Research. 2016; 6(2): 167-170. doi: 10.5958/2349-2996.2016.00031.8
5. V. Komathi. Effectiveness of Guided Imagery on Level of Blood Pressure among PIH Mothers in Selected Hospital at Trichy. Intenational Journal of Advances in Nursing Management. 2015; 3(3): 245-252. doi: 10.5958/2454-2652.2015.00011.6
6. WHO. Make every mother and child count.The World Health Report. Geneva Switzerland: World Health Organization;2005.
7. Ann Maria Thomas. Effect of Planned Teaching Programme on Knowledge and Practices in Relation to Prevention of Complications among selected High Risk Antenatal Mothers in a Selected Hospital. Asian Journal Nursing Education and Research. 2017; 7(3): 308-320. doi: 10.5958/2349-2996.2017.00064.7
8. Rupali, Kaur Ramandeep, Sharma Sonia. A Quasi Experimental Study to Assess the Effectiveness of Exhibition on Knowledge regarding Pregnancy Induced Hypertension among Antenatal Mothers attending Antenatal Outpatient Department of Selected Hospitals, Jalandhar, Punjab. Intenational Journal of Advances in Nursing Management. 2015; 3(4): 367-371. doi: 10.5958/2454-2652.2015.00036.0
9. Maram Jbaily, Firas Hussein, NisrinKaddar. The Role of Serum Lactate Dehydrogenase in Etiological Diagnosis of Macrocytic Anemia. Research Journal of Pharmacy and Technology. 2022; 15(12): 5421-4. doi: 10.52711/0974-360X.2022.00913
10. S. Shenbagavalli, K. Menaka. Effectiveness of selected nursing intervention on maternal and newborn outcome among primigravida mothers at selected hospitals.Asian Journal Nursing Education and Research. 2016; 6(3): 407-410. doi: 10.5958/2349-2996.2016.00072.0
11. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000 Jul; 183(1): S1-S22. PMID: 10920346
12. L. Myatt, R.P. Webster, Vascular biology of preeclampsia, J. Thromb. Haemost. 2009; 7: 375–384 https://doi.org/10.1111/j.1538-7836.2008.03259.x
13. Gehan. H.Soliman, Seham Mohamed Abd Elalem, Samah Mohamed Elhomosy. The Effect of Relaxation Techniques on Blood Pressure and Stress among Pregnant Women with Mild Pregnancy Induced Hypertension. Asian Journal Nursing Education and Research. 2017; 7(3): 321-329. doi: 10.5958/2349 - 2996.2017.00065.9
14. Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? Haram K1, Mortensen JH2, Mastrolia SA3,4, Erez O4. J MaternFetal Neonatal Med. 30(7), 2017, 779-788. doi: 10.1080/14767058.
15. Sneha Jose. Effect of Planned Teaching Programme on Knowledge of Immediate Care of Low Birth Weight Babies among Staff Nurses working in Neonatal Intensive Care Unit in selected Hospitals of an Urban Area Asian Journal Nursing Education and Research. 2017; 7(2): 209-218. doi: 10.5958/2349-2996.2017.00043.X
16. Wagner SJ, Barac S, Garovic VD. Hypertensive pregnancy disorders: Current concepts. J Clin Hypertens (Greenwich) 2007;9:560 566.DOI: 10.1111/j.1524-6175.2007.06695.x
17. Qublan HS, Amarun V, Bateinen O, et al. LDH as biochemical marker of adverse pregnancy outcome in severe preeclampsia. Med Sci Monit. 2005; 11: 393–397. PMID: 16049382
18. He S, Bremme K, Kallner A, Blombäck M. Increased concentrations of lactate dehydrogenase in pregnancy with preeclampsia: a predictor for the birth of small-for-gestational-age infants. GynecolObstet Invest. 1995;39(4):234-8. DOI: 10.1159/000292417.
19. Jaiswar SP, Amrit G, Rekha S, Natu SN, Mohan S. Lactic dehydrogenase: A biochemical marker for preeclampsia–eclampsia. J Obstet Gynaecol India. 2011; 61(6): 645-648.DOI: 10.1007/s13224-011-0093-9
20. Aabidha PM, Cherian AG, Paul E, Helan J. Maternal and fetal outcome in pre-eclampsia in a secondary care hospital in South India. J Fam Med Primary Care. 2015; 4: 257-60. DOI: 10.4103/2249-4863.154669
21. Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 8. IFCC method for lactate dehydrogenase (l-Lactate: NAD+ Oxidoreductase, EC 1.1.1.27). International Federation of Clinical Chemistry (IFCC).1994;32(8):639-655.
22. CortonMM,Leveno K,Bloom S, et al. Pregnancy hypertension. Chapter 34.23rdedn.In: Williams obstetrics.McGraw Hill Professional; 2009.
23. Jain R, Upadhyay C, Mehta L, NayakB, DesaiG.Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat. Int J Reprod Contracept Obstet Gynecol. 2017; 6: 3418-22. DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20173455
24. Demir SC, Evruke C, Ozgunen FT, Urunsak IF, Candan E, Kadayifci O. Factors that influence morbidity and mortality in severe preeclampsia, eclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome. Saudi Med J. 2006 Jul; 27(7): 1015-8. PMID: 16830022