Author(s): Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandaril

Email(s): zzainiyah@gmail.com

DOI: 10.52711/0974-360X.2024.00349   

Address: Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandaril
Profesional Midwives Study Program, Institute of Health Science Ngudia Husada Madura, Bangkalan, Madura 69116, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
ABSTRACT: Identification of Polymorphism Angiotensin II Types 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels is a way of early detection for the prevention of preeclampsia. The primary objective of this investigation was to examine the correlation between AT1 and potassium with the incidence of preeclampsia. A case-control study involving 100 pregnant participants was conducted, with 50 individuals in the case group (diagnosed with pre-eclampsia) and 50 in the control group (comprising healthy pregnant women). The chosen cases exhibited specific traits, including an occurrence of single pregnancies, an age range of 20 to 40 years, elevated blood pressure exceeding 140/90mmHg, and a gestational age exceeding 20 weeks. The control group possessed the following characteristics: they were healthy pregnant women who visited the Syamrabu Bangkalan Public Hospital, third-generation Madura natives without pre-eclampsia or chronic hypertension. Additionally, they were free from other pregnancy complications, were aged between 20-40 years, and had a gestational age exceeding 20 weeks. The findings revealed that among individuals with preeclampsia (PE), one had CC (homozygotes), constituting 2%, five had AC (heterozygote), representing 8%, and 45 had the AA genotype (homozygotes), accounting for 90%. In contrast, for those without preeclampsia, none had CC (homozygote) at 0%, 11 had AC (heterozygote), comprising 26.7%, and 33 had the AA genotype (homozygotes), making up 73.3%. The majority of both preeclampsia (PE) and non-preeclampsia (non-PE) cases exhibited the A alleles and AA genotype (homozygote). The AT1R 1166 A/C polymorphism emerged as a notable risk factor for preeclampsia, whereas the potassium level did not exhibit a significant impact on its occurrence. Additional investigations are required to explore the implications across diverse races and ethnicities.


Cite this article:
Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandaril. Identification of Polymorphism Angiotensin II Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population. Research Journal of Pharmacy and Technology. 2024; 17(5):2217-3. doi: 10.52711/0974-360X.2024.00349

Cite(Electronic):
Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandaril. Identification of Polymorphism Angiotensin II Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population. Research Journal of Pharmacy and Technology. 2024; 17(5):2217-3. doi: 10.52711/0974-360X.2024.00349   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-45


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