Author(s): Lalita Sandey, Shruti Rathore, Sharda Shambhakar, Amit Roy


DOI: 10.52711/0974-360X.2024.00370   

Address: Lalita Sandey1*, Shruti Rathore1, Sharda Shambhakar2, Amit Roy3
1,2Banasthali Vidyapeeth, Jaipur, Rajsthan, India.
1LCIT School of Pharmacy, Bilaspur, CG, India.
3Chhatrapati Shivaji Institute of Pharmacy, Durg, CG, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024

The aim of present research work to develop and characterize modafinil loaded mucoadhesive niosomes for brain targeting through nasal route. The modafinil is a BCS Class II drug for the treatment of Narcolepsy. Preformulation study of drug were done for identification, solubility and for partition coefficient by using UV Spectroscopy and FTIR Spectroscopy. Modafinil loaded niosomes were prepared by thin layer hydration vortex method using cholesterol, soya lecithin, surfactant and N Palmitoyl – L Glucosamine as excipients. Best niosomes were selected on the basis of particle size and drug entrapment efficiency and was considered as optimized formulation N10. Then, optimized formulation was coated with different concentration of mucoadhesive polymer chitosan and were again characterized for particle size, polydispersity index and for zeta potential and values were 241.60nm, 0.290 and +29.5mV respectively, at optimum concentration 2mg/ml of coating material. C10 was the best formulation after coating. In vitro drug release was done by using dialysis sac method for determining rate and extent of drug diffusion from pure drug suspension, N10 and C10 formulations. This study had showed that less drug release from drug suspension (38.63%) as compared to N10 (54.95%) and C10 (70.01%) within 4hr. Chitosan coated niosomes C10 were stable up to 12 weeks under storage conditions 4°C and 25°C in simulated nasal fluid. Leakage study at 4°C, 25°C and 37°C also revealed that increase in temperature increase drug leakage from niosomes.

Cite this article:
Lalita Sandey, Shruti Rathore, Sharda Shambhakar, Amit Roy. Development and Characterization of Modafinil Loaded Mucoadhesive Niosomes: A Targeted Drug Delivery to Brain. Research Journal of Pharmacy and Technology. 2024; 17(5):2365-1. doi: 10.52711/0974-360X.2024.00370

Lalita Sandey, Shruti Rathore, Sharda Shambhakar, Amit Roy. Development and Characterization of Modafinil Loaded Mucoadhesive Niosomes: A Targeted Drug Delivery to Brain. Research Journal of Pharmacy and Technology. 2024; 17(5):2365-1. doi: 10.52711/0974-360X.2024.00370   Available on:

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