ABSTRACT:
Minoxidil is a vasodilating agent used to treat pattern hair loss and resistant hypertension. New spectrophotometric techniques have been proposed for the estimation of Minoxidil in pharmaceutical dosage forms. Double beam Shimadzu Model UV-1800UV-VIS spectrophotometer was used for the present study. Minoxidil has shown linearity over the concentration range 0.1-20 µg/mL in distilled water, acetate buffer (pH 4.0), phosphate buffer (pH 5.8), borate buffer (pH 9.0), methanol and 0.1-15 µg/mL in phosphate buffer (pH 7.8) and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Minoxidil in pharmaceutical dosage forms.
Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Polipalli Venkata Navya, Angirekula Narendra. New spectrophotometric methods for the determination of Minoxidil. Research Journal of Pharmacy and Technology. 2024; 17(5):2372-8. doi: 10.52711/0974-360X.2024.00371
Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Polipalli Venkata Navya, Angirekula Narendra. New spectrophotometric methods for the determination of Minoxidil. Research Journal of Pharmacy and Technology. 2024; 17(5):2372-8. doi: 10.52711/0974-360X.2024.00371 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-67
REFERENCES:
1. Lowenthal DT, Affrime MB. Pharmacology and pharmacokinetics of Minoxidil. J Cardiovasc Pharmacol. 1980; 2 (2): 93-106.
2. Khadeerunnisa S, Vimalak Kannan T, Vijaya Lakshmi T. Spectrophotometric determination and estimation of Minoxidil in tablet dosage form by UV. Int. J. Res. Pharm. Chem & Anal. 2019; 1(2): 47-51
3. Rogerio Adelino De S, Felipe Silva S, Priscila C, and Eder Tadeu Gomes. Determination of Minoxidil by bleaching the permanganate carrier solution in a flow-based spectrophotometric system. Analytical Letters. 2011; 44: 349-359.
4. Zarghi A, Safaati A, Foroutan S.M, Khoddam A. Rapid determination of Minoxidil in human plasma using ion-pair HPLC. Journal of Pharmaceutical and Biomedical Analysis. 2004; 36: 377–379
5. Mio I, Chiharu Fu, Rena S, Ryotaro M, Hajime I. Simultaneous determination of Minoxidil and Minoxidil sulfate by high performance liquid chromatography with UV-detection and its applications. Medicine in Drug Discovery. 2020; (7)100050: 2590-0986.
6. Hemant K G, Jagdish P B, Akshay S, Manjusha S, Ganesh P D, Ashish H T. Development and Validation of Stability Indicating HPLC Method for the estimation of Minoxidil and related substance in topical formulation. Journal of Pharmacy Research. 2011; 4 (12):
7. Lai-Hao, and Pei-Tung. Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals. Current Analytical Chemistry. Bentham Science Publishers. 2019; 15: 575-582
8. Poorna Basuri P, Vijayakumar R, Nalini C.N. Estimation of Minoxidil in human plasma using UHPLC-MS/MS and its application in pharmacokinetic study. Journal of Chromatography B. 2022; 1192, 123104.
9. Mathrusri Annapurna M, Souvik Das, Narendra A and Raja Kumar V. Validated new spectrophotometric methods for the estimation of Bosentan in bulk and pharmaceutical dosage forms. Journal of Pharm Educ Res. 2010; 1 (2): 73-76.
10. Mathrusri Annapurna M, Bisht SPS, Ravi Kumar BVV, Raja Kumar V and Narendra A. Spectrophotometric determination of Bosentan and its application in pharmaceutical analysis. International Journal of Comprehensive Pharmacy. 2011; 2 (2): 1-3.
11. Narendra A, Deepika D and Mathrusri Annapurna M. New spectrophotometric method for the determination of Bosentan – An anti-hypertensive agent in pharmaceutical dosage forms. E- Journal of Chemistry. 2012; 9(2): 700-704.
12. Narendra A, Deepika D and Mathrusri Annapurna M. Validated spectrophotometric methods for the determination of Mycophenolate: an Anti-neoplastic agent in bulk and pharmaceutical dosage forms. Journal of Chemistry. 2013; Article ID 523193.
13. Narendra A, Deepika D and Mathrusri Annapurna M. Determination of Emtricitabine by derivative spectrophotometric method in pharmaceutical dosage forms. Chemical Science Transactions. 2013; 2(3): 978-982.
14. ICH Q2 [R1] Validation of Analytical Procedures: Text and Methodology: November (2005).