Author(s):
Neelam Mehta, Itishri Jena, Subhashree Ray, Sudeshna Behera, Surjeet Sahoo
Email(s):
dritishrijena82@gmail.com
DOI:
10.52711/0974-360X.2024.00470 
Address:
Neelam Mehta1, Itishri Jena2*, Subhashree Ray2, Sudeshna Behera2, Surjeet Sahoo3
1Department of Pathology, TATA Main Hospital, Jamshedpur, 831001, Jharkhand, India.
2Department of Biochemistry, IMS and SUM Hospital, Bhubaneswar, 751003, Odisha, India.
3Department of Psychiatry, IMS and SUM Hospital, Bhubaneswar, 751003, Odisha, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 7,
Year - 2024
ABSTRACT:
The underlying etiopathogenesis of long-term psychiatric disorder schizophrenia is not clear. Hyperhomocystenemia is known to play important role in ethiopathogenesis and development of many cognitive disorder including schizophrenia. The present study was undertaken to find out the association between plasma homocysteine with Positive And Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) of newly detected schizophrenic patients. PANSS and BPRS are commonly used symptoms rating scale of schizophrenia. Assessment of plasma homocysteine, PANSS and BPRS were done in 30 schizophrenic patients and compared with 50 gender and age matched healthy individuals. The plasma homocysteine, BPRS score and PANSS score of schizophrenic patients were 15.48±2.71 µmol/L, 84.2±1.72, 149.01±1.72 respectively, which were significantly high in comparison to controls. This raised value of homocysteine is also positively and significantly correlated with BPRS and PANSS of study population. This study suggests the role of high homocysteine level in development and progression of schizophrenia.
Cite this article:
Neelam Mehta, Itishri Jena, Subhashree Ray, Sudeshna Behera, Surjeet Sahoo. Correlation Study of Plasma Homocysteine with PANSS and BPRS of Newly Detected Schizophrenic patientsResearch Journal of Pharmacy and Technology.2024; 17(7):3009-2. doi: 10.52711/0974-360X.2024.00470
Cite(Electronic):
Neelam Mehta, Itishri Jena, Subhashree Ray, Sudeshna Behera, Surjeet Sahoo. Correlation Study of Plasma Homocysteine with PANSS and BPRS of Newly Detected Schizophrenic patientsResearch Journal of Pharmacy and Technology.2024; 17(7):3009-2. doi: 10.52711/0974-360X.2024.00470 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-7-3
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