Author(s):
Pednekar. A. S, Sowmya. C, Mamle Desai. S. N, P. Jovita. M. M. D
Email(s):
drcsowmya@sriramachandra.edu.in , pednekar_arti@sriramachandra.edu.in , snm101991@gmail.com , jovimartin4@gmail.com
DOI:
10.52711/0974-360X.2024.00549 
Address:
Pednekar. A. S, Sowmya. C, Mamle Desai. S. N, P. Jovita. M. M. D
Faculty of Pharmacy,-Sriramachandra Institute of Higher Education and Research (Deemed to be University) Porur Chennai – 600116.
*Corresponding Author
Published In:
Volume - 17,
Issue - 7,
Year - 2024
ABSTRACT:
The skin carcinoma is predominantly observed in white population. Based upon clinical behaviour carcinoma may be classified as non-melanomatous skin carcinoma and malignant melanoma. Further cells affected non-melanomatous skin carcinoma is classified as basal cell carcinoma and squamous cell carcinoma.. Andrographolide is a potent anticancer agent. It is isolated mostly from the leaves and roots of Andrographis Paniculata and chemically is a labdane diterpenoid. It is useful in the treatment of carcinoma of colon, breast, head, neck, prostate, glioblastoma and skin. Inhibiting proliferation and inducing apoptosis is the mechanism by which cancerous cells acts in treating carcinoma. 14-acetylandrographolide, one of the potent derivative of andrographolide.
Cite this article:
Pednekar. A. S, Sowmya. C, Mamle Desai. S. N, P. Jovita. M. M. D. Andrographolide: A Drug of Choice for Skin Carcinoma. Research Journal of Pharmacy and Technology. 2024; 17(7):3514-0. doi: 10.52711/0974-360X.2024.00549
Cite(Electronic):
Pednekar. A. S, Sowmya. C, Mamle Desai. S. N, P. Jovita. M. M. D. Andrographolide: A Drug of Choice for Skin Carcinoma. Research Journal of Pharmacy and Technology. 2024; 17(7):3514-0. doi: 10.52711/0974-360X.2024.00549 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-7-82
REFERENCES:
1. Khan NH, Mir M, Qian L, Baloch M, Khan MF, Ngowi EE, Wu DD, Ji XY. Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures. J. Adv. Res.. 2022; Feb 1; 36: 223-47. doi: 10.1016/j.jare.2021.06.014.
2. Millsop JW, Sivamani RK, Fazel N. Botanical agents for the treatment of nonmelanoma skin cancer. Dermatol. res. pract. 2013; Jan 1; 2013. doi:10.1155/2013/837152.
3. Chauhan P. Skin cancer and role of herbal medicines. AJPP. 2018; Aug; 4(4): 404-12. doi:10.31024/ajpp.2018.4.4.5.
4. Zeng B, Wei A, Zhou Q, Yuan M, Lei K, Liu Y, Song J, Guo L, Ye Q. Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches. Phytother Res. 2022; Jan; 36(1): 336-64. doi: 10.1002/ptr.7324.
5. Kim DP, Kus KJB, Ruiz E. Basal Cell Carcinoma Review. Hematol Oncol Clin North Am. 2019; Feb; 33(1): 13-24. doi: 10.1016/j.hoc.2018.09.004..
6. Intharuksa A, Arunotayanun W, Yooin W, Sirisa-Ard P. A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. Molecules. 2022; Jul 13; 27(14): 4479. doi: 10.3390/molecules27144479.
7. Ihsan BR, Hafid AF, Primaharinastiti R, Widyawaruyanti A, Yuwono M. Development and validation of hplc method for determination of andrographolide in raw material and tablet of ethyl acetate fractions of Andrographis paniculata. Research J. Pharm. and Tech 2020. 2020; 13(9): 4291-6. doi: 10.5958/0974-360X.2020.00758.1
8. Levita J, Nawawi AA, Mutalib A, Ibrahim S. Andrographolide: a review of its anti-inflammatory activity via inhibition of NF-kappaB activation from computational chemistry aspects. IJP-International Journal of Pharmacology. 2010; 6(5): 569-76. doi: 10.3923/ijp.2010.569.576
9. Varma A, Padh H, Shrivastava N. Andrographolide: a new plant-derived antineoplastic entity on horizon. Evid Based Complement Alternat Med. 2011; 2011: 815390. doi: 10.1093/ecam/nep135.
10. Wong SK, Chin KY, Ima-Nirwana S. A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury. Drug Des Devel Ther. 2021; Nov 10; 15: 4615-32. doi: 10.2147/DDDT.S331027
11. Vetvicka V, Vannucci L. Biological properties of andrographolide, an active ingredient of Andrographis Paniculata: a narrative review. Ann Transl Med. 2021; Jul; 9(14): 1186. doi: 10.21037/atm-20-7830
12. Venkateswaran S, D'Angelo N. Cutaneous Malignant Melanoma: A Synthesis on Updated Guidelines for the Primary Care Perspective. HCA Healthc J Med. 2020; Dec 29; 1(6): 475-480. doi: 10.36518/2689-0216.1104
13. Al Batran R, Al-Bayaty F, Al-Obaidi MM, Abdulla MA. Acute toxicity and the effect of andrographolide on Porphyromonas gingivalis-induced hyperlipidemia in rats. Biomed Res Int. 2013; 2013: 594012. doi: 10.1155/2013/594012
14. Naik PP. Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management. World J Oncol. 2021; Feb; 12(1): 7-19. doi: 10.14740/wjon1349.
15. Yerragunta, V., Waghray, K., Shivraj, . and Subhashini, N. J. P. Anti-Cancer Activity of Andrographolide: A Review, Journal of Pharmaceutical Research International. 2021; 33(43B): pp. 1–9. doi: 10.9734/jpri/2021/v33i43B32519
16. Burton KA, Ashack KA, Khachemoune A. Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease. Am J Clin Dermatol. 2016; Oct; 17(5): 491-508. doi: 10.1007/s40257-016-0207-3.
17. Dey, Y. Nandan; Kumari. S; Ota.S, Srikanth. N. Phytopharmacological review of Andrographis paniculata (Burm.f) Wall. ex Nees. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2013; Jan–Mar. 3(1): 3-10. | DOI: 10.4103/2231-0738.106973
18. Akilandeswari G, Anand AV, Sampathkumar P, Moorthi PV, Preethi B. A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata. SRP. 2019; 10(1): 15-9. doi:10.5530/srp.2019.1.3
19. Shi MD, Lin HH, Lee YC, Chao JK, Lin RA, Chen JH. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem Biol Interact. 2008; Aug 11; 174(3): 201-10. doi: 10.1016/j.cbi.2008.06.006
20. Komalasari T, Harimurti S. A Review on the Anti-diabetic Activity of Andrographis paniculata (Burm. f.) Nees based In-vivo Study. IJPHS. 2015; Dec; 4(4): 256-63. doi: 10.11591/ijphs.v4i4.4743
21. Chao WW, Lin BF. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010; May 13; 5-17. doi: 10.1186/1749-8546-5-17
22. Zhan JY, Wang XF, Liu YH, Zhang ZB, Wang L, Chen JN, Huang S, Zeng HF, Lai XP. Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation. Mediators Inflamm. 2016; 2016: 3271451. doi: 10.1155/2016/3271451
23. Ziech D, Franco R, Georgakilas AG, Georgakila S, Malamou-Mitsi V, Schoneveld O, Pappa A, Panayiotidis MI. The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chem Biol Interact. 2010; Nov 5; 188(2): 334-9. doi: 10.1016/j.cbi.2010.07.010.
24. Zhong QY, Lin B, Chen YT, Huang YP, Feng WP, Wu Y, Long GH, Zou YN, Liu Y, Lin BQ, Sang NL, Zhan JY. Gender differences in UV-induced skin inflammation, skin carcinogenesis and systemic damage. Environ Toxicol Pharmacol. 2021; Jan; 81: 103512. doi: 10.1016/j.etap.2020.103512..
25. Candido J, Hagemann T. Cancer-related inflammation. J Clin Immunol. 2013; Jan; 33 Suppl 1: 79-84. doi: 10.1007/s10875-012-9847-0.
26. Ghahartars M, Sedaghat F, Khajavi E, Nejat AA, Malekzadeh M, Ghaderi A, Fattahi MJ. Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer. Dermatol Res Pract. 2021; Jun 18; 2021: 5540163. doi: 10.1155/2021/5540163.
27. Hop HT, Reyes AWB, Huy TXN, Arayan LT, Min W, Lee HJ, Rhee MH, Chang HH, Kim S. Activation of NF-kB-Mediated TNF-Induced Antimicrobial Immunity Is Required for the Efficient Brucella abortus Clearance in RAW 264.7 Cells. Front Cell Infect Microbiol. 2017; Oct 9; 7: 437. doi: 10.3389/fcimb.2017.00437
28. Li Z, Li B, Yu H, Wang P, Wang W, Hou P, Li M, Chu S, Zheng J, Mao L, Bai J. DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability. Oncogene. 2022; Aug; 41(33): 3991-4002. doi: 10.1038/s41388-022-02404-9.
29. Zhao Y, Song W, Wang Z, Wang Z, Jin X, Xu J, Bai L, Li Y, Cui J, Cai L. Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation. Redox Biol. 2018; Apr; 14: 609-17. doi: 10.1016/j.redox.2017.11.007
30. Chien CF, Wu YT, Lee WC, Lin LC, Tsai TH. Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact. 2010; Mar 30; 184(3): 458-65. doi: 10.1016/j.cbi.2010.01.017.
31. Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine. 2000; Oct; 7(5): 351-64. doi: 10.1016/S0944-7113(00)80054-9.
32. Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine. 2006; May; 13(5): 318-23. doi: 10.1016/j.phymed.2005.06.005.
33. Pandey G, Rao CH. Andrographolide: its pharmacology, natural bioavailability and current approaches to increase its content in andrographispaniculata. Int J Complement Alt Med. 2018; 11(6): 355-60. DOI: 10.15406/ijcam.2018.11.00425
34. Suneetha A, Manasa K. Development and Validation of Visible Spectrophotometric Method for Determination of Andrographolide in Kalmegh Plant Extract. Asian J. Pharm. Ana. 2014; 4(2): 85-8.
35. Ghumare P, Dolas RT, Aher V. Development of HPTLC method for the estimation of andrgrapholide from Arjuna Tablet. Asian Journal of Pharmaceutical Analysis. 2021; 11(2): 156-8. doi: 10.52711/2231-5675.2021.00027
36. Bhope SG, Kuber VV, Patil MJ, Ghosh VK. Validated HPTLC Method for the Quantitation of Andrographolide from Raw Material and Pharmaceutical Dosage Form. Asian J. Research Chem. 2(3): July-Sept.: 314-7
37. Jadhao M, Wankhade V. Estimation and Quantification of Andrographolide in herbal powder and polyherbal Asava by HPTLC. Asian J. Research Chem. 2011; 4(1): 68-70.
38. Sari R, Tunggadewi S, Paramanandana A, Yusuf H. Preparation and Physical Characterization of Andrographolide-Chitosan-Alginate Microparticles prepared by Ionic Gelation–Freeze Drying Research J. Pharm. and Tech. 2019; 12(2): 553-7. doi: 10.5958/0974-360X.2019.00098.2
39. Saini V, Bala R, Arora S. Formulation and Evaluation of Phyto-phospholipid complex of Methanolic Extract of leaves of Andrographis paniculate. Research J.Pharm. and Tech. 2023; Feb 28; 16(2): 830-4. doi: 10.52711/0974-360X.2023.00141
40. Afokoghene AJ, Eziuzo OS, Lynda NC. Antimicrobial investigation, Formulation and Evaluation of Andrographis paniculata aqueous herbal cream for topical application. Research J.Pharm. and Tech. 2022; 15(8): 3553-8. doi: 10.52711/0974-360X.2022.00596
41. Shakila R, Elankani P, Jegajothipandian S. Development of Finger Print Profiles for Androgrphis echioides Nees. and Andrographis paniculata Nees. Res. J. Pharmacognosy and Phytochem. 2014; 6(1): 22-9.
42. Mamillapalli V, Katamaneni M, Tiyyagura VM, Kanajam P, Namagiri AP, Thondepu H, Appikatla B, Devangam B, Khantamneni P. Formulation, phytochemical, physical, biological evaluation of polyherbal vanishing cream, and facewash. Research J.Pharm. and Tech. 2020; 12(3): 139-49. doi:10.5958/0975-4377.2020.00024.5
43. Simões MF, Sousa JS, Pais AC. Skin cancer and new treatment perspectives: A review. Cancer letters. 2015; Feb 1; 357(1): 8-42. doi: 10.1016/j.canlet.2014.11.001.
44. Montagna W. The structure and function of skin. Elsevier; 2012 Dec 2.
45. Dika E, Scarfì F, Ferracin M, Broseghini E, Marcelli E, Bortolani B, Campione E, Riefolo M, Ricci C, Lambertini M. Basal cell carcinoma: a comprehensive review. Int. J. Mol. Sci. 2020; Aug 4; 21(15): 1-11. doi: 10.3390/ijms21155572
46. Kabir S, Schmults CD, Ruiz ES. A review of cutaneous squamous cell carcinoma epidemiology, diagnosis, and management. Int J Cancer Manag. 2018; Jan 31; 11(1). doi: 10.5812/ijcm.60846
47. Naik PP. Cutaneous malignant melanoma: A review of early diagnosis and management. World J. Oncol. 2021; Feb; 12(1): 7-19. doi:10.14740/wjon1349
48. Wortsman X. Sonography of the primary cutaneous melanoma: a review. Radiol Res Pract. 2012; 2012: 814396. doi: 10.1155/2012/814396.
49. Zeng B, Wei A, Zhou Q, Yuan M, Lei K, Liu Y, Song J, Guo L, Ye Q. Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches. Phytother Res. 2022; Jan; 36(1): 336-64. doi: 10.1002/ptr.7324.