Author(s):
Karlina Amir Tahir, Syatirah Jalaluddin, Muh Fitrah, Ahmad Lalo, Syamsuri Syakri, Upik A. Miskad, Maulita Indrisari, Katsuyoshi Matsunami
Email(s):
karlina.amir@uin-alauddin.ac.id
DOI:
10.52711/0974-360X.2025.00712 
Address:
Karlina Amir Tahir1, Syatirah Jalaluddin1, Muh Fitrah1, Ahmad Lalo2, Syamsuri Syakri1, Upik A. Miskad3, Maulita Indrisari4, Katsuyoshi Matsunami5
1Faculty of Medicine and Health Sciences, State Islamic University of Alauddin Makassar, Makassar, Indonesia.
2National Agency of Drug and Food Control, Makassar, Indonesia.
3Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
4Department of Pharmacotherapy, Palangka Raya University, Palangka Raya, Central Kalimantan, Indonesia.
5Department of Pharmacognosy, School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
Introduction: Lung cancer is the health problem in developed countries. The main causes of lung cancer in general include carcinogens such as tobacco smoke, ionizing radiation, and viral infections. This exposure causes cumulative changes to the DNA in the tissue lining the bronchial epithelium. Methods: Chromolaena odorata was extracted with methanol, then partitioned with 5 dissolutions; n-Hexane, Ethyl Acetate, Acetonitric, n-Buthanol, Ethanol. The five extracts obtained were tested with A549 cells using the bioassay method. After incubation, the result obtained from microplate reader. Result: The percentage inhibition of the five extracts was showed that the Ethanol extract was the most active, with the highest value among other solvents. The A549 cell line was isolated in 1973 from lung adenocarcinoma in a study to create a continuous cell line from 200 different tumors. Although developed as a tool for cancer research, the cell line was later characterized as representative of the Alveolar Type II pneumocytes from the human lung. The cell line has been a mainstay of respiratory research for nearly forty years. Conclusion: The Ethanol extract of Chromolaena odorata has a potential to inhibit the growth of the A549 cell line
Cite this article:
Karlina Amir Tahir, Syatirah Jalaluddin, Muh Fitrah, Ahmad Lalo, Syamsuri Syakri, Upik A. Miskad, Maulita Indrisari, Katsuyoshi Matsunami. The Inhibition of A549 cells from Siam Weeds (Chromolaena odorata L.). Research Journal of Pharmacy and Technology. 2025;18(10):4934-8. doi: 10.52711/0974-360X.2025.00712
Cite(Electronic):
Karlina Amir Tahir, Syatirah Jalaluddin, Muh Fitrah, Ahmad Lalo, Syamsuri Syakri, Upik A. Miskad, Maulita Indrisari, Katsuyoshi Matsunami. The Inhibition of A549 cells from Siam Weeds (Chromolaena odorata L.). Research Journal of Pharmacy and Technology. 2025;18(10):4934-8. doi: 10.52711/0974-360X.2025.00712 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-10-51
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