Author(s):
Darmawansyih, Rosdiana Natzir, Ika Yustisia, Firdaus Hamid, Asri Saleh, Syamsuri Syakri
Email(s):
darmawansyih@uin-alauddin.ac.id
DOI:
10.52711/0974-360X.2025.00670 
Address:
Darmawansyih1,6*, Rosdiana Natzir2, Ika Yustisia2, Firdaus Hamid3, Asri Saleh4, Syamsuri Syakri5
1Department of Medical, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin Makassar, Indonesia.l
2Department of Biochemistry, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
3Departement of Clinical Mikrobiology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
4Chemistry Study Program, Science and Technology Faculty, Universitas Islam Negeri Alauddin, Makassar, Indonesia.
5Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin Makassar, Indonesia.
6Doctoral Program, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits".Alpha mangosteen is one of the most abundant chemical compounds in the mangosteen fruit's skin (Garcinia mangostana L). It is known to have many benefits and is high in antioxidant properties, so it can be used as adjuvant therapy for several diseases, such as diabetes mellitus (DM). Many proteins are involved in the pathophysiology of DM. This study aims to explore the binding of alpha mangosteen to various protein receptors involved in the pathophysiology of DM through molecular docking. This research used molecular docking with Autodock Tools software and the Discovery Studio Visualizer Program. The Protein used was obtained from the Protein Data Bank database https://www.rcsb.org, while the 3D structure of a-mangosteen was obtained from PubCheme https://pubchem.ncbi.nlm.nih.gov. Of the six proteins that were carried out by molecular docking on alpha mangosteen, five proteins had a "good" binding category (good solution, RMSD ? 2), namely AKT serine/threonine kinase 1 (AKT1), peroxisome proliferator-activated receptor gamma (PPARG), albumin (ALB), tumor protein p53 (TP53), growth differentiation factor-15 (GDF-15); and there is one Protein that has an "acceptable" binding category (acceptable solution; RMSD 2-3), namely Signal Transducer and activator of transcription 3 (STAT3). Alpha mangosteen can interact with several proteins involved in the Pathophysiology of DM, as proven through molecular docking analysis and in vitro and in vivo studies. It strengthens the evidence for the potential of alpha mangosteen as an adjuvant therapy in DM.
Cite this article:
Darmawansyih, Rosdiana Natzir, Ika Yustisia, Firdaus Hamid, Asri Saleh, Syamsuri Syakri. In silico of Secondary Metabolite Compounds in Garcinia mangostana as A Therapy for Type 2 Diabetes. Research Journal of Pharmacy and Technology. 2025;18(10):4660-6. doi: 10.52711/0974-360X.2025.00670
Cite(Electronic):
Darmawansyih, Rosdiana Natzir, Ika Yustisia, Firdaus Hamid, Asri Saleh, Syamsuri Syakri. In silico of Secondary Metabolite Compounds in Garcinia mangostana as A Therapy for Type 2 Diabetes. Research Journal of Pharmacy and Technology. 2025;18(10):4660-6. doi: 10.52711/0974-360X.2025.00670 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-10-9
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