Author(s):
Nadie Fatimatuzzahro, Hanna Alifia Pratiwi, Rendra Chriestedy Prasetya, Amandia Dewi Permana Shita, Dwi Kartika Apriyono, Nuzulul Hikmah, Hafiedz Maulana
Email(s):
nadie.fkg@unej.ac.id
DOI:
10.52711/0974-360X.2025.00789 
Address:
Nadie Fatimatuzzahro1*, Hanna Alifia Pratiwi2, Rendra Chriestedy Prasetya1, Amandia Dewi Permana Shita1, Dwi Kartika Apriyono3, Nuzulul Hikmah1, Hafiedz Maulana1
1Department of Dentistry, Biomedical Science, Oral Pathology and Maxillofacial, Faculty of Dentistry, Universitas Jember, Jember 68121, Indonesia.
2Undergraduate Program, Faculty of Dentistry, Jember 68121, Universitas Jember, Indonesia.
3Department of Dentistry, Forensic Odontology, Faculty of Dentistry, Jember 68121, Universitas Jember, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Background: periodontitis is an inflammatory disease of periodontal tissue. Porphyromonas gingivalis is the main periodontopathogenic bacteria by inducing macrophages and lymphocytes which can stimulate an increase in Receptor Activator of ?B Ligand (RANKL) and decreased Osteoprotegerin (OPG) can activate osteoclast proliferation and cause alveolar bone damage. Robusta coffee husk contains flavonoids, tannins and caffeine which act as anti-inflammatory. This study aimed to analyze the effect of robusta coffee husk extract on the number of osteoblasts and osteoclasts in the alveolar bone of Wistar rats induced by Porphyromonas gingivalis for 21 days. Method: laboratory experimental research type, 24 rats were divided into 6 random groups, the normal group (KN); Porphyromonas gingivalis induced rat group (K-); group of rats induced by Porphyromonas gingivalis and given metronidazole (K+); group of rats induced by Porphyromonas gingivalis and given 125 mg/kg BW robusta coffee husk extract (KP 125); group of rats induced by Porphyromonas gingivalis and given 250mg/kg BW robusta coffee husk extract (KP 250); group of rats induced by Porphyromonas gingivalis and given 500mg/kg BW (KP 500) robusta coffee husk extract and euthanized on the 22nd day. Tissues were processed and stained with Haematoxylin Eosin (HE). Calculations of osteoblasts and osteoclasts in the alveolar bone area of the buccal part of the lower left M1 tooth, then analyzed with one-way ANOVA statistics. Results: there was a significant difference between the number of osteoblasts and osteoclasts KP 125 and KP 250 with KN and K+. The mean number of osteoblasts and osteoclasts did not differ significantly between KP 500 and KN and K+. Conclusion: robusta coffee husk extract at a dose 250 mg/kg BW effective to increase the number of osteoblasts and reduce alveolar bone osteoclasts in rats induced by Porphyromonas gingivalis.
Cite this article:
Nadie Fatimatuzzahro, Hanna Alifia Pratiwi, Rendra Chriestedy Prasetya, Amandia Dewi Permana Shita, Dwi Kartika Apriyono, Nuzulul Hikmah, Hafiedz Maulana. Robusta Coffee Husk Extract as a Promising Natural Compound for The Treatment of Periodontitis: A Focus on Alveolar Bone Resorption and Formation. Research Journal Pharmacy and Technology. 2025;18(11):5472-8. doi: 10.52711/0974-360X.2025.00789
Cite(Electronic):
Nadie Fatimatuzzahro, Hanna Alifia Pratiwi, Rendra Chriestedy Prasetya, Amandia Dewi Permana Shita, Dwi Kartika Apriyono, Nuzulul Hikmah, Hafiedz Maulana. Robusta Coffee Husk Extract as a Promising Natural Compound for The Treatment of Periodontitis: A Focus on Alveolar Bone Resorption and Formation. Research Journal Pharmacy and Technology. 2025;18(11):5472-8. doi: 10.52711/0974-360X.2025.00789 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-51
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