ABSTRACT:
Human skin, a marvel of natural engineering, has garnered significant interest for its potential in revolutionizing systemic drug delivery. Despite its robust protective function against external threats, the skin poses challenges when it comes to efficiently delivering topical medications. To meet the demand for more effective dermatological treatments, various innovative strategies have emerged to overcome the skin's formidable barrier. Among these, Film Forming Systems (FFS) have emerged as a promising breakthrough in both topical and transdermal drug delivery. FFS formulations offer an economically viable and user-friendly approach, making them a compelling option for enhancing patient outcomes. The ideal FFS effortlessly creates a film on the skin's surface, maintaining continuous contact with the dermal layer for extended period. This enables flexible dosing for a wide spectrum of skin conditions. In the forthcoming article, we offer a concise yet comprehensive exploration of various aspects related to film-forming systems. This includes an examination of the underlying mechanisms driving their efficacy, an analysis of the tangible benefits they bring to the table, insights into the key design considerations that influence their performance, an overview of the intricacies involved in their formulation, practical applications across dermatology, and robust assessment techniques to gauge their effectiveness. This article aims to provide a well-rounded understanding of FFS, shedding light on its potential as a game-changer in the realm of drug delivery through the skin.
Cite this article:
Sanika Kuveskar, Ashwini Wani. Designing effective Film-Forming Systems: Key Considerations and Strategies. Research Journal of Pharmacy and Technology.2025;18(2):919-6. doi: 10.52711/0974-360X.2025.00135
Cite(Electronic):
Sanika Kuveskar, Ashwini Wani. Designing effective Film-Forming Systems: Key Considerations and Strategies. Research Journal of Pharmacy and Technology.2025;18(2):919-6. doi: 10.52711/0974-360X.2025.00135 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-2-67
REFERENCES:
1. K. Naga Durga, P. Bhuvaneswari, B. Hemalatha, K. Padmalatha. A Review on Transdermal Drug Delivery System. Asian Journal of Pharmacy and Technology. 2022; 12(2): 159-6. doi: 10.52711/2231-5713.2022.00027
2. Kathe K. and Kathpalia H.: Film Forming Systems for Topical and Transdermal Drug Delivery. Asian J. Pharm. Sci. 2017; 12 (6): 487–497.
3. Eswaraiah S., Swetha K., Lohita M., P. Jaya Preethi, B. Priyanka, Kiran Kumar Reddy. Emulgel: Review on Novel Approach to Topical Drug Delivery. Asian J. Pharm. Res. 4(1): Jan.-Mar. 2014; 04-11.
4. Tran T. T. D. and Tran P. H. L. Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery. Pharmaceutics. 2019; 11 (6): 1–16.
5. Frederiksen K., Guy R. H. and Petersson K.: The Potential of Polymeric Film-Forming Systems as Sustained Delivery Platforms for Topical Drugs. Expert Opin. Drug Deliv. 2016; 13 (3): 349–360.
6. Hayder Yahya Mansoor Al-Jarsha, Mowafaq M. Ghareeb, Ahmed A. Hussein. A Review on Film Forming Drug Delivery Systems. Research Journal of Pharmacy and Technology. 2021; 14(10): 5579-8.
7. Kanchan R. Pagar, Sarika V. Khandbahale. A Review on Novel Drug Delivery System: A Recent Trend. Asian J. Pharm. Tech. 2019; 9(2): 135-140.
8. Rakesh K Sindhu, Mansi Chitkara, Gagandeep Kaur, Preeti Jaiswal, Ashutosh Kalra, Inderbir Singh, Pornsak Sriamornsak. Skin Penetration Enhancer’s in Transdermal Drug Delivery Systems. Research J. Pharm. and Tech. 2017; 10(6): 1809-1815.
9. Pünnel, L. C., and Lunter, D. J. Film-forming systems for dermal drug delivery. Pharmaceutics. 2021; 13(7); 932.
10. Herbert A. Lieberman, Martin M. Reiger and Gilbert S. Pharmaceutical Dosage Forms: Disperse Systems. Volume 2. Informa Healthcare USA, Inc. 2008.
11. Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg. Emulgel: A Review. Asian Journal of Pharmaceutical Research. 2021; 11(4): 263-8.
12. AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar. Formulation, Optimization and Evaluation of Glibenclamide Transdermal Patches by using chitosan Polymer. Asian J. Pharm. Tech. 2019; 9(1): 01-07.
13. Karki S., Kim H., Na S. J., Shin D., Jo K., and Lee J.: Thin Films as an Emerging Platform for Drug Delivery. Asian J. Pharm. Sci. 2016; 11 (5): 559–574.
14. Schroder I. Z.: Film Forming Polymeric Solutions as Drug Delivery Systems for the Skin Dissertação de Doutorado 2007; 111–121.
15. Bornare S. S., Aher S. S., and Saudagar R. B.: A Review: Film Forming Gel Novel Drug Delivery System. Int. J. Curr. Pharm. Res. 2018; 10 (2): 25-28.
16. Gennari C. G. M., Selmin F., Minghetti P., and Cilurzo F.: Medicated Foams and Film Forming Dosage Forms as Tools to Improve the Thermodynamic Activity of Drugs to Be Administered Through the Skin. Curr. Drug Deliv. 2019; 16 (5): 461–471.
17. Bhilegaonkar, S. and Parvatkar, A. Eudragit: A versatile and robust platform. Int. J. Pharm. Sci. Res, 2020l; 11: 2626-2635.
18. Guarve, K. and Kriplani, P. HPMC-A Marvel Polymer for Pharmaceutical Industry-Patent Review. Recent Advances in Drug Delivery and Formulation: Formerly Recent Patents on Drug Delivery and Formulation. 2021; 15(1): pp.46-58.
19. Klucel: Available at: https://www.ashland.com/file_source/Ashland/Product/Documents/ Pharmaceutical/PC_11229_Klucel_HPC.pdf [Accessed 26 April 2022]
20. Chandak A. R. and Verma P. R. P.: Development and Evaluation of HPMC Based Matrices for Transdermal Patches of Tramadol. Clin. Res. Regul. Aff. 2008; 25 (1): 13–30.
21. Oh D. W., Kang J. H., Lee H. J., Han S. D., Kang M. H., Kwon Y. H., et al. Formulation and in Vitro/in Vivo Evaluation of Chitosan-Based Film Forming Gel Containing Ketoprofen. Drug Del. 2017; 24 (1): 1056–1066.
22. Joshi M.: Role of Eudragit in Targeted Drug Delivery. Int. J. Curr. Pharm. Res. 2013; 5 (2): 58–62.
23. Buhler V.: Polyvinylpyrrolidone excipients for pharmaceuticals povidone, crospovidone, and copovidone. Berlin: Springer-Verlag Berlin and Heidelberg GmbH and Co. K: 2004, 1-3.
24. Rekhi G. S. and Jambhekar S. S.: Ethylcellulose – a Polymer Review. Drug Dev. Ind. Pharm. 1995; 21 (1): 61–77.
25. Bajaj H., Kumar T., and Singh V.: Film-forming gels: a review. Res. J. Pharm. Biol. Chem. Sci. 2016; 7(4): 2085–2091.
26. Werbowyj R. S. and Gray D. G.: Optical Properties of (Hydroxypropyl)Cellulose Liquid Crystals. Cholesteric Pitch and Polymer Concentration. Macromolecules 1984; 17 (8): 1512–1520.
27. Repka M. A. and McGinity J. W.: Bioadhesive Properties of Hydroxypropylcellulose Topical Films Produced by Hot-Melt Extrusion. J. Control. Release 2001; 70 (3): 341–351.
28. Klykken P., Servinski M., and Thomas X.: Silicone Film-Forming Technologies for Health Care Applications. Dow Corning 2009; 1–8.
29. Algin-Yapar E. and Onal O.: Transdermal Spray in Hormone Delivery. Trop. J. Pharm. Res. 2014; 13 (3): 469–474.
30. Lu W., Luo H., Wu Y., Zhu Z. and Wang H.: Preparation and Characterization of a Metered Dose Transdermal Spray for Testosterone. Acta Pharm. Sin. B. 2013; 3 (6): 392–399.
31. Santos, P., Watkinson, A. C., Hadgraft, J., and Lane, M. E. Oxybutynin permeation in skin: The influence of drug and solvent activity. International Journal of Pharmaceutics. 2010; 384(1-2): 67-72.
32. Ammar H. O., Ghorab M., Mahmoud A. A., Makram T. S., and Ghoneim A. M.: Rapid Pain Relief Using Transdermal Film Forming Polymeric Solution of Ketorolac. Pharm. Dev. Technol. 2013; 18 (5): 1005–1016.
33. Edwards A., Qi S., Liu F., Brown M. B., and McAuley W. J.: Rationalizing Polymer Selection for Supersaturated Film Forming Systems Produced by an Aerosol Spray for the Transdermal Delivery of Methylphenidate. Eur. J. Pharm. Biopharm. 2017; 114: 164–174.
34. Pravin D. Harak, Amar G. Zalte, Vishal S. Gulecha. Formulation and Evaluation of Film Forming Solution of Tavaborole for Treatment of Skin Infections. Research Journal of Pharmacy and Technology. 2023; 16(3): 1342-6.
35. R.B. Saudagar, S. Samuel. Formulation Development and Evaluation of Topical Film-Forming Lotion Containing Butenafine Hydrochloride. Asian J. Pharm. Tech. 2016; 6(4): 238-248.
36. Altenhofen Da Silva M., Adeodato Vieira M. G., Gomes Maumoto A. C., and Beppu M. M.: Polyvinylchloride (PVC) and Natural Rubber Films Plasticized with a Natural Polymeric Plasticizer Obtained through Polyesterification of Rice Fatty Acid. Polym. Test. 2011; 30 (5): 478–484.
37. Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque. Design and Evaluation of Transdermal Patches Containing Risperidone. Asian J. Res. Pharm. Sci. 2016; 6(4): 208-222.
38. Saikumar Y., Saikishore V., Pavani K., Sairam D.T., Sindhura A.Role of Penetration Enhancers in Transdermal Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 300-308.
39. Ranade S., Bajaj A., Londhe V., Babul N., and Kao D.: Fabrication of Topical Metered Dose Film Forming Sprays for Pain Management. Eur. J. Pharm. Sci. 2017; 100: 132–141.
40. Li R. Y., Wang A. P., Xu J. H., Xi L. Y., Fu M. H., Zhu M., et al. Efficacy and Safety of 1% Terbinafine Film-Forming Solution in Chinese Patients with Tinea Pedis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study. Clin. Drug Investig. 2014; 34 (3): 223–230.
41. G. Vasavi, P. Naga Haritha, B. Chandrashekar. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3): 123-129.
42. Asasutjarit R., Larpmahawong P., Fuongfuchat A., Sareedenchai V., and Veeranondha S.: Physicochemical Properties and Anti-Propionibacterium Acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract. AAPS Pharm. Sci. Tech. 2014; 15 (2): 306–316.
43. Zurdo Schroeder I., Franke P., Schaefer U. F., and Lehr C. M.: Development and Characterization of Film Forming Polymeric Solutions for Skin Drug Delivery. Eur. J. Pharm. Biopharm. 2007; 65 (1): 111–121.
44. Gohel M. C. and Nagori S. A.: Fabrication of Modified Transport Fluconazole Transdermal Spray Containing Ethyl Cellulose and Eudragit® RS100 as Film Formers. AAPS Pharm. Sci. Tech. 2009; 10 (2): 684–691.
45. Reid M. L., Benaouda F., Khengar R., Jones S. A., and Brown M. B.: Topical Corticosteroid Delivery into Human Skin Using Hydrofluoroalkane Metered Dose Aerosol Sprays. Int. J. Pharm. 2013; 452 (1–2): 157–165.
46. Lu W., Luo H., Zhu Z., Wu Y., Luo J., and Wang H.: Preparation and the Biopharmaceutical Evaluation for the Metered Dose Transdermal Spray of Dexketoprofen. J. Drug Deliv. 2014, 1–12.
47. Bakkiyaraj D., Sritharadol R., Padmavathi A. R., Nakpheng T. and Srichana T. Anti-Biofilm Properties of a Mupirocin Spray Formulation against Escherichia Coli Wound Infections. Biofouling 2017; 33 (7): 591–600.
48. Sritharadol R., Nakpheng T., Wan Sia Heng P. and Srichana T. Development of a Topical Mupirocin Spray for Antibacterial and Wound-Healing Applications. Drug Dev. Ind. Pharm. 2017: 43 (10); 1715–1728.
49. Jayesh S. Gharat, Yogita V. Dalvi. Compressive Review on Hydrogel. Asian J. Pharm. Tech. 2018; 8 (3):172-181.
50. M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G. Formulation and Evaluation of Chitosan Based Polyelectrolyte Complex Hydrogels for Extended Release of Metoprolol Tartrate. Research J. Pharm. and Tech. 2011; 4(12): Dec. 1844-1851.
51. Saudagar R. B. and Gangurde P. A. Formulation, Development and Evaluation of Film-Forming Gel for Prolonged Dermal Delivery of Miconaole Nitrate. Res. J. Top. Cosmet. Sci. 2017; 8 (1): 19-29.
52. Kim D. W., Kim K. S., Seo Y. G., Lee B. J., Park Y. J., Youn Y. S., et al. Novel Sodium Fusidate-Loaded Film-Forming Hydrogel with Easy Application and Excellent Wound Healing. Int. J. Pharm. 2015; 495 (1): 67–74.
53. Vij N. N. and Saudagar R. B.: Formulation, Development and Evaluation of Film-Forming Gel for Prolonged Dermal Delivery of Terbinafine Hydrochloride. Int. J. Pharma Sci. Res. 2014; 5 (9): 537-554.
54. Gennari C. G. M., Selmin F., Ortenzi M. A., Franzé S., Musazzi U. M., Casiraghi A., et al. In Situ Film Forming Fibroin Gel Intended for Cutaneous Administration. Int. J. Pharm. 2016; 511 (1): 296–302.
55. Li X., Zhang R., Liang R., Liu W., Wang C., Su Z., Sun F., and Li Y.: Preparation and Characterization of Sustained-Release Rotigotine Film-Forming Gel. Int. J. Pharm. 2014; 460 (1–2): 273–279.
56. Liu X., Fu L., Dai W., Liu W., Zhao J., Wu Y., et al. Design of Transparent Film-Forming Hydrogels of Tolterodine and Their Effects on Stratum Corneum. Int. J. Pharm. 2014; 471 (1–2): 322–331.
57. An N. M., Kim D. D., Shin Y. H. and Lee C. H.: Development of a Novel Soft Hydrogel for the Transdermal Delivery of Testosterone. Drug Dev. Ind. Pharm. 2003; 29 (1): 99–105.
58. Parhi R. and Goli V. V. N.: Design and Optimization of Film-Forming Gel of Etoricoxib Using Research Surface Methodology. Drug Deliv. Transl. Res. 2019; 1–17.
59. Lunter D. J.: Daniels R. New Film Forming Emulsions Containing Eudragit® NE and/or RS 30D for Sustained Dermal Delivery of Nonivamide. Eur. J. Pharm. Biopharm. 2012; 82 (2): 291–298.
60. Malik R., Venkatesh K. S., Dwivedi A. K., and Misra A.: Episodic Transdermal Delivery of Testosterone. Mol. Pharm. 2012; 9 (6): 1537–1543.
61. Heck R., Lukic M., Savic S. D., Daniels R., and Lunter D. J.: Ex Vivo Skin Permeation and Penetration of Nonivamide from and in Vivo Skin Tolerability of Film-Forming Formulations Containing Porous Silica. Eur. J. Pharm. Sci. 2017; 106 (May): 34–40.
62. Gupta A. K., Shear N. H., Lester R. S., Baxter M. L., and Sauder D. N.: Betamethasone dipropionate polyacrylic film‐forming lotion in the treatment of hand dermatitis. Int. J. Dermatol. 1993; 32 (11): 828–829.