Author(s):
M. T. Deshmukh, T. V. Deshmukh, V.T. Deshmukh, M. R. Ghante
Email(s):
madhuripharmacist9@gmail.com
DOI:
10.52711/0974-360X.2025.00172 
Address:
M. T. Deshmukh1*, T. V. Deshmukh2,V.T. Deshmukh3, M. R. Ghante4
1Department of Pharmaceutics, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Maharshtra, India.
2Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandals, College of Pharmacy Malegaon BK, Baramati maharshtra, India
3Department of Pharmaceutics, Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa Maharshtra, India.
4Department of Pharmaceutics, Meruling Shikshan Sansthas’s College of Pharmacy, Jawalwadi, Medha.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2025
ABSTRACT:
The clinically important dopamine receptor employed in schizophrenia was proven to be the source of the second generation atypical antipsychotic medication that was licensed in UA in 1996. However, less than 60% of it is absorbed due to considerable first-pass metabolism. The goal of this research was to create a microsphere of Olanzapine in order to increase its bioavailability and prevent hepatic first pass metabolism. Different concentrations of sodium alginate and carbopol polymer were used in a factorial design. They were assessed test like Porsolt swim, tail suspension, elevated plus maze, and tail suspension test in animals (Wistar albino rats and mice) in order to assess the effectiveness of antidepressants. The result showed a considerable reduction in immobility duration when compared to group I (normal).An optimized batch study using wistar rats was conducted to assess the antidepressant impact of administering Olanzapine microsphere over A.P.I.
Cite this article:
M. T. Deshmukh, T. V. Deshmukh,V.T. Deshmukh, M. R. Ghante. Preparation and Evaluation of Olanzepine Microsphere for Treatment of Depression and Obessive Compulsive Disorder. Research Journal of Pharmacy and Technology. 2025;18(3):1189-1. doi: 10.52711/0974-360X.2025.00172
Cite(Electronic):
M. T. Deshmukh, T. V. Deshmukh,V.T. Deshmukh, M. R. Ghante. Preparation and Evaluation of Olanzepine Microsphere for Treatment of Depression and Obessive Compulsive Disorder. Research Journal of Pharmacy and Technology. 2025;18(3):1189-1. doi: 10.52711/0974-360X.2025.00172 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-3-33
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