Author(s):
Puneet Kamra, Nitin Rawal, Sansar Chand Sharma, Mrudul Kyada, Akshay Vadhroliya, Akshay Bhatiya
Email(s):
mrudulkyada@ymail.com
DOI:
10.52711/0974-360X.2025.00442 
Address:
Puneet Kamra1, Nitin Rawal1, Sansar Chand Sharma2, Mrudul Kyada3*, Akshay Vadhroliya3, Akshay Bhatiya3
1Assistant Professor, SGT Medical College and Research Institute, Gurugram, Haryana, India.
2Professor, SGT Medical College and Research Institute, Gurugram, Haryana, India.
3Junior Resident, SGT Medical College and Research Institute, Gurugram, Haryana, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Background: Periarthritis of the shoulder, characterised by pain and stiffness, poses challenges in management. While corticosteroid injections are commonly used, platelet-rich plasma (PRP) has emerged as a potential alternative due to its regenerative properties. This study aims to compare the efficacy of intra-articular injections of triamcinolone versus PRP in treating periarthritis of the shoulder. Methods: A parallel-group, prospective, randomised clinical trial was conducted. Fifty patients diagnosed with periarthritis were randomised into two groups: Triamcinolone (n=25) and PRP (n=25). Pain and functional outcomes were assessed using Visual Analog Scale (VAS) and Disabilities of Arm, Shoulder, and Hand (DASH) scores at baseline 1, 3 and 6 Months post-injection. Statistical analyses were performed to compare outcomes between the two groups. Results: At baseline, there were no significant differences between groups in age, sex distribution, side involvement, or symptom duration. Both groups showed improvement in VAS and DASH scores at 3 months, with PRP demonstrating superior outcomes at 6 months . The PRP group exhibited significantly lower VAS scores and better functional recovery compared to the Triamcinolone group at 6 months (P<0.05). Conclusion: Intra-articular injections of PRP offer superior long-term benefits compared to triamcinolone in managing periarthritis of the shoulder. While both treatments improve pain and functional outcomes initially, PRP demonstrates prolonged efficacy, highlighting its potential as a promising alternative in periarthritis management.
Cite this article:
Puneet Kamra, Nitin Rawal, Sansar Chand Sharma, Mrudul Kyada, Akshay Vadhroliya, Akshay Bhatiya. Comparative efficacy of Platelet Rich Plasma (PRP) vs Triamcinolone injections in Periarthritis Shoulder: Unveiling long-term benefits. Research Journal of Pharmacy and Technology. 2025;18(7):3085-8. doi: 10.52711/0974-360X.2025.00442
Cite(Electronic):
Puneet Kamra, Nitin Rawal, Sansar Chand Sharma, Mrudul Kyada, Akshay Vadhroliya, Akshay Bhatiya. Comparative efficacy of Platelet Rich Plasma (PRP) vs Triamcinolone injections in Periarthritis Shoulder: Unveiling long-term benefits. Research Journal of Pharmacy and Technology. 2025;18(7):3085-8. doi: 10.52711/0974-360X.2025.00442 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-7-22
REFERENCES:
1. Dias R, Cutts S, Massoud S: Frozen shoulder. BMJ. 2005, 331: 1453-6. 10.1136/bmj.331.7530.1453
2. Buchbinder R, Green S: Effect of arthrographic shoulder joint distension with saline and corticosteroid for adhesive capsulitis. Br J Sports Med. 2004; 38: 384-5. 10.1136/bjsm.2004.013532
3. Shah N, Lewis M: Shoulder adhesive capsulitis: systematic review of randomised trials using multiple corticosteroid injections. Br J Gen Pract. 2007, 57:662-7.
4. Le HV, Lee SJ, Nazarian A, Rodriguez EK: Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. 2017, 9: 75-84. 10.1177/1758573216676786
5. Yong Ho Kim, Gul-Won Bang. Development of 3D Exercise Treatment Machine for Articular Cartilage Repair. Research J. Pharm. and Tech. 2019; 12(5): 2485-2489. doi: 10.5958/0974-360X.2019.00417.7
6. A. Anitha, J. Sridevi, S. Anusuya, V.N. Avinash. Effectiveness of End Range Mobilization along with conventional therapy in patients with Periarthritis Shoulder. Research J. Pharm. and Tech 2020; 13(3): 1271-1276. doi: 10.5958/0974-360X.2020.00234.6
7. Song A, Higgins LD, Newman J, Jain NB: Glenohumeral corticosteroid injections in adhesive capsulitis: a systematic search and review. PM R. 2014, 6: 1143-56. 10.1016/j.pmrj.2014.06.015
8. Pedersen AB, Horváth-Puhó E, Ehrenstein V, Rørth M, Sørensen HT: Frozen shoulder and risk of cancer: a population-based cohort study. Br J Cancer. 2017; 117: 144-7. 10.1038/bjc.2017.146
9. Hussein Gamal Hussein Mogahed, Nabil Abdo Mohamed, Mahmoud Hamada Mohamed Abdel Wahed. Impact of 8-Weeks Combined Cyriax Soft Tissue Release and Proprioceptive Neuromuscular Facilitation on Glenohumeral Rhythm in Post Mastectomy Adhesive Capsulitis. Research J. Pharm. and Tech. 2020; 13(10):4903-4908. doi: 10.5958/0974-360X.2020.00862.8
10. Levine WN, Kashyap CP, Bak SF, Ahmad CS, Blaine TA, Bigliani LU: Nonoperative management of idiopathic adhesive capsulitis. J Shoulder Elbow Surg. 2007; 16: 569-73. 10.1016/j.jse.2006.12.007
11. Samara M. Ali, Sarmad M.H. Mohammed Zeiny, Mohammed Qasim MalAllah AlAtrakji. Effect of Prp on Gingival Health in Pregnants: Immunological Aspect. Research J. Pharm. and Tech 2017; 10(11): 3969-3973. doi: 10.5958/0974-360X.2017.00721.1
12. Yin W, Xu H, Sheng J, Xu Z, Xie X, Zhang C: Comparative evaluation of the effects of platelet‐rich plasma formulations on extracellular matrix formation and the NF‐κB signaling pathway in human articular chondrocytes. Mol Med Rep. 2017; 15: 2940-8. 10.3892/mmr.2017.6365
13. Kothari SY, Srikumar V, Singh N: Comparative efficacy of platelet rich plasma injection, corticosteroid injection and ultrasonic therapy in the treatment of periarthritis shoulder. J Clin Diagn Res. 2017; 11:RC15-8. 10.7860/JCDR/2017/17060.9895
14. Dhillon RS, Schwarz EM, Maloney MD. Platelet-rich plasma therapy future or trend? Arthritis Research & Therapy 2012; 14(4): 219.
15. Kumar V, Poovaiah, Ravish VN: Randomized controlled trial of functional outcome of periarthritis of shoulder (adhesive capsulitis) in a group of 60 patients using intraarticular triamcinolone vs. intraarticular platelet rich plasma. Indian J Orthop Surg. 2021; 7:57-61.
16. Barman A, Mukherjee S, Sahoo J, et al.: Single intra-articular platelet-rich plasma versus corticosteroid injections in the treatment of adhesive capsulitis of the shoulder: a cohort study. Am J Phys Med Rehabil. 2019; 98: 549-57. 10.1097/PHM.0000000000001144
17. Chauhan S, Kothari SY, Laisram N: Comparison of ultrasonic therapy, sodium hyaluronate injection and steroid injection in the treatment of periarthritis shoulder. Indian J Physical Med Rehabil. 2012; 23:105-10. 10.5005/ijopmr-23-3-105
18. Gupta GK, Shekhar S, Haque ZU, Halder S, Manjhi AK, Rai A. Comparison of the Efficacy of Platelet-Rich Plasma (PRP) and Local Corticosteroid Injection in Periarthritis Shoulder: A Prospective, Randomized, Open, Blinded End-Point (PROBE) Study. Cureus. 2022; Sep 17; 14(9): e29253. doi: 10.7759/cureus.29253. PMID: 36262947; PMCID: PMC9574604.
19. Sheridan MA, Hannafin JA: Upper extremity: emphasis on frozen shoulder. Orthop Clin North Am. 2006; 37: 531-9. 10.1016/j.ocl.2006.09.009
20. Griesser MJ, Harris JD, Campbell JE, Jones GL: Adhesive capsulitis of the shoulder: a systematic review of the effectiveness of intra-articular corticosteroid injections. J Bone Joint Surg Am. 2011; 93:1727-33. 10.2106/JBJS.J.01275
21. Blanchard V, Barr S, Cerisola FL: The effectiveness of corticosteroid injections compared with physiotherapeutic interventions for adhesive capsulitis: a systematic review. Physiotherapy. 2010; 96:95- 107. 10.1016/j.physio.2009.09.003
22. Buchbinder R, Green S, Youd JM: Corticosteroid injections for shoulder pain . Cochrane Database Syst Rev. 2003; CD004016. 10.1002/14651858.CD004016