ABSTRACT:
Risperidone is an anti-psychotic drug used for the treatment of mood and mental health conditions including schizophrenia and bipolar disorders. New spectrophotometric methods have been proposed for the estimation of Risperidone in pharmaceutical dosage forms using Shimadzu Model UV-1800 Double beam UV-VIS spectrophotometer. Risperidone has shown linearity over the concentration range 1-50 µg/ml in phosphate buffer (pH 7.0), acetate buffer (pH 4.0) and phosphate buffer (pH 7.5) and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Risperidone in tablet dosage forms.
Cite this article:
Vejandla Swathi Lakshmi, Mukthinuthalapati Mathrusri Annapurna, Tangeti Nischala Sai. Vejandla Swathi Lakshmi, Mukthinuthalapati Mathrusri Annapurna, Tangeti Nischala Sai. Research Journal of Pharmacy and Technology. 2025;18(7):3336-9. doi: 10.52711/0974-360X.2025.00482
Cite(Electronic):
Vejandla Swathi Lakshmi, Mukthinuthalapati Mathrusri Annapurna, Tangeti Nischala Sai. Vejandla Swathi Lakshmi, Mukthinuthalapati Mathrusri Annapurna, Tangeti Nischala Sai. Research Journal of Pharmacy and Technology. 2025;18(7):3336-9. doi: 10.52711/0974-360X.2025.00482 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-7-62
REFERENCES:
1. Smith C, Rahman T, Toohey N, Mazurkiewicz J, Herrick-Davis K, Teitler M. Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor. Molecular Pharmacology. 2006; 70 (4): 1264–70.
2. Risperidone. CAS Common Chemistry. CAS, a division of the American Chemical Society. https://commonchemistry.cas.org/detail?cas_rn=106266-06-2 (retrieved 2025-06-03) (CAS RN: 106266-06-2).
3. M. Sravan Kumar, A. Anton Smith, G. AlagumaniVasagam, A.Kottai Muthu and R.Manavalan. Development of Analytical Method for Risperidone by UV Spectrophotometry. 2010; 1(2):122-126.
4. G. Alagumani Vasagam, A. Anton Smith, CH. Nawas, M. Sravan Kumar, A. Kottai Muthu and R. Manavalan. Development of analytical method for Risperidone by UV Spectrophotometry using methanol as a solvent. 2010; 2(3): 309-315.
5. B. K. Jayanna, T. D. Devaraj, K. P. Roopa, G. Nagendrappa, H. R. Arun Kumar, and N. Gowda. Spectrophotometric Estimation of Risperidone in Tablets. 2014; 76(5): 452–455.
6. Moynul Hasan, Abdullh Al Masud and Jamiuddin Ahmed. Development and validation of spectrophotometric method for the determination of risperidone in bulk drug and pharmaceutical formulation. IJPSR. 2011; 2(2): 378-382.
7. Kulkarni, Chhabra, Shivani. Development and validation of UV spectrophotometric method for the determination of risperidone in bulk and tablets formulation. 2012; 2(1):10-14.
8. B. Narayana, K. Veena. A new and simple method for the spectrophotometric determination of risperidone. Oxidation Communications. 2011; 34(3): 660–666.
9. Idris, A.Y., Usman, M.A., Musa, A. and Oloyede. Spectrophotometric determination of risperidone in pure and tablet dosage forms by formation of a coloured ion-pair complex with bromocresol green. 2015; 14(1): 41-46.
10. S. Archana, Y. Naga Prasanna, P. Pavitra, D. Santhi Krupa, M. Hema Sri. Development and validation of spectrophotometric method for determination of risperidone by MBTH. IJPSR 2013; 4(3): 1116-1119.
11. Krishna Prasad Davarasingi, Kunapa Reddy Lahari Durga, Palakurthi Siva Sai Chandra, Kudeli Krishna Teja and Atla Srinivasa Rao. Estimation of risperidone in tablet dosage form using uv spectrophotometric method. 12(9): 2219-2225
12. Vivek Jain, Vijay Kumarand Prabhat Kumar Jain. Simple Cost Effective and Ecofriendly Spectrophotometric Method Development and Validation for Quantitative Estimation of Risperidone Using Hydrotropic Agent. 2019; 1(4): 88-91.
13. ICH Validation of analytical procedures: Text and Methodology Q2 (R1), International Conference on Harmonization, 2005.