ABSTRACT:
The addition of emulsion to gel evidently produced an emulgel, which, as a dual control release system, has made emulgel one of the most promising topical delivery technologies. The manufacturing of a Voriconazole Emulgel was the aim of this research work and carbopol 934P was used as a gelling agent. In addition to delivering the medication to the location where it is most apt to have an effect, topically administered medication would then sit longer at the location of action. An emulgel with concentrated 934P polymer, high transparency, film forming ability and viscosity lowers the drug release profile. The optimal concentration for maximum antibacterial and in vitro drug release is 0.6:0.4 carbopol 934P. The formulation was subjected to in vitro drug release, rheology, spreading coefficient and microbiological tests. The Emulgel in vitro release rate was determined on a Franz diffusion cell hybridized with a dialysis membrane and phosphate buffer pH 5.5. After one month under stability conditions, physical appearance and pH of the improved Emulgel, as well as its rheological characteristics and drug content, remained unchanged. The formulation's rheological properties, drug content, and drug release are all improved using carbopol 934P in a 0.6:0.4 (F6) ratio.