Author(s):
Svetlana Ivasenko, Assemgul Bokayeva, Assel Ramazanova
Email(s):
bokaevaa@qmu.kz
DOI:
10.52711/0974-360X.2025.00595 
Address:
Svetlana Ivasenko, Assemgul Bokayeva, Assel Ramazanova
NCJSC "Karaganda Medical University", 100000, Kazakhstan, Karaganda City, St. Gogol 40.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
This article presents a study of the antibacterial activity of pharmaceutical compositions in the form of liquid dosage forms—syrups, suspensions, and emulsions—containing a dry extract of Thymus crebrifolius at various concentrations, against Helicobacter pylori. Antimicrobial activity was assessed using the agar diffusion method. The study established pronounced antibacterial activity against Helicobacter pylori in all samples of the pharmaceutical compositions. The highest antibacterial effect against the test strain was demonstrated by Syrup ?1 and Emulsion ? 5, at comparable concentrations of the dry extract of Thymus crebrifolius.
Cite this article:
Svetlana Ivasenko, Assemgul Bokayeva, Assel Ramazanova. Study of the Antibacterial Effect of Pharmaceutical Compositions Based on Dry Extract of Thymus crebrifolius. Research Journal of Pharmacy and Technology. 2025;18(9):4141-3. doi: 10.52711/0974-360X.2025.00595
Cite(Electronic):
Svetlana Ivasenko, Assemgul Bokayeva, Assel Ramazanova. Study of the Antibacterial Effect of Pharmaceutical Compositions Based on Dry Extract of Thymus crebrifolius. Research Journal of Pharmacy and Technology. 2025;18(9):4141-3. doi: 10.52711/0974-360X.2025.00595 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-9-15
REFERENCES:
1. Tulegenova A. U. et al. State Pharmacopoeia of the Republic of Kazakhstan. Zhibek Zholy. – 2008. – Т. 1.
2. Patent of the Republic of Kazakhstan No. 34162 for the invention dated 02/11/2020. The use of dry Thymus crebrifolius extract is often associated with (Thymus crebrifolius Klok.) as a broad-spectrum antimicrobial agent. Akhmetalimova A.M., Bokayeva A.B., Ivasenko S.A., Akhmetova S.B., Loseva I.V.
3. Akhmetalimova A.M., Bokayeva A.B., Ivasenko S.A., Akhmetova S.B., Ludvichuk A. Antimicrobial activity and acute toxicity of Thymus crebrifolius dry extract. Pharmacy. – 2019. – Special Issue. – pp. 469–471.
4. Sabiyeva A. et al. Anatomical study of Dracocephalum ruyschiana L. and Dracocephalum nutans L .Research Journal of Pharmacy and Technology. 2023; 16(3) 1193-1198.
5. Sabiyeva A. et al. Histochemical analysis of aerial part of Dracocephalum ruyschiana L. and Dracocephalum nutans L. growing in the Territory of Central Kazakhstan. Research Journal of Pharmacy and Technology. 2022; 15(9): 3831-3835.
6. Ramazanova A. et al. Antimicrobial activity of the dense extracts of Dracocephalum nutans L. and Dracocephalum ruyschiana L //Bulletin of the Karaganda University. Biology medicine geography Series. 2024.– Т. 11629. – No.. 4. – С. 178-182.
7. Atazhanova G. et al. Component Composition and Antimicrobial Activity of Dracocephalum nutans L. Essential Oil. Research Journal of Pharmacy and Technology. 2023; 16(10): 4881-4885.
8. Kurmantayeva G. K. et al. Morphological and Anatomical Study of Aerial organs of Nepeta pannonica L. Research Journal of Pharmacy and Technology. 2024; 17(11): 5311-5316.
9. Turdiyeva Z. A. et al. Histochemical analysis of the aerial part of Ferula songarica growing in the territory of the Karaganda region (Central Kazakhstan). Research Journal of Pharmacy and Technology. 2023; 16(11): 5079-5084.
10. Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.. Formulation and Evaluation of Antibacterial Herbal gels of Murraya koenigii Leaves Extract. Research J. Pharm. and Tech. 2017; 10(6): 1798-1801. doi: 10.5958/0974-360X.2017.00317.1
11. S. Sundar, K. Padmalatha, SK. Apsana, P. Himaja, V. Nandini, D. Sirisha. Antibacterial and Antifungal Activity of Carica papaya L Seed Extracts. Research J. Pharm. and Tech. 2021; 14(2): 1085-1090. doi: 10.5958/0974-360X.2021.00195.5
12. Ahmed Mishaal Mohammed, Mahmood Mohammed Ali. Synthesis and Characterisation of Zirconium Oxide Nanoparticles Via the Hydrothermal Method and Evaluation of their Antibacterial Activity. Research J. Pharm. and Tech. 2021; 14(2): 938-942. doi: 10.5958/0974-360X.2021.00167.0
13. Hisham A. Abbas, Islam M. Abdo, Mahmoud Z. Moustafa. In vitro Antibacterial and Antibiofilm Activities of Hibiscus sabdariffa L. Extract and Apple Vinegar against Bacteria Isolated from Diabetic Foot Infections. Research J. Pharm. and Tech. 2014; 7(2): Feb. 131-136. doi: Not Available
14. Happy Agarwal, Soumya Menon, S. Rajeshkumar, S. Venkat Kumar. Green Synthesis of Silver Nanoparticle using Kalanchoe pinnata leaf extract and its Antibacterial Effect against Gram-Positive and Gram-Negative Species. Research J. Pharm. and Tech. 2018; 11(9): 3964-3968. doi: 10.5958/0974-360X.2018.00728.X