Author(s):
Parul Singh, Nidhi Srivastava, Akash Ved
Email(s):
parul9161@gmail.com
DOI:
10.52711/0974-360X.2025.00629 
Address:
Parul Singh1*, Nidhi Srivastava2, Akash Ved3
1PSIT- Pranveer Singh Institute of Technology, (Pharmacy), Kanpur - 209305, Uttar Pradesh, India.
1,2School of Pharmaceutical Sciences, Maharishi University of Information Technology, Lucknow, Uttar Pradesh, India.
3Dr. A. P. J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
Diabetes mellitus, particularly type 2 diabetes, remains a critical global health challenge necessitating novel therapeutic approaches. Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as promising agents in diabetes management by enhancing glucose regulation through incretin hormone stabilization. This study investigates the molecular docking interactions between DPP-4 (PDB ID: 2OQV) and a series of 2-methyl-N-(1,3-dioxoisoindolin-2-yl) benzamide derivatives. Our docking simulations revealed significant binding affinities, with docking scores ranging from -8.0 to -9.0 and the docking score of the Co-crystallize ligand is -10.1. Compound P-2 exhibited the highest affinity with a docking score of -9.0, demonstrating multiple stable interactions with key residues such as Tyr662. Comparative analysis highlighted the robust binding profiles of compounds P-1, P-3, and P-4, underscoring their potential as effective DPP-4 inhibitors. These findings provide a foundation for further in vitro and in vivo studies to validate and optimize these compounds, advancing the development of next-generation antidiabetic agents.
Cite this article:
Parul Singh, Nidhi Srivastava, Akash Ved. Exploring the Binding Affinities of 2-Methyl-N-(1,3-Dioxoisoindolin-2-yl) Benzamide Derivatives as Potent DPP-4 Inhibitors". Research Journal of Pharmacy and Technology. 2025;18(9):4389-5. doi: 10.52711/0974-360X.2025.00629
Cite(Electronic):
Parul Singh, Nidhi Srivastava, Akash Ved. Exploring the Binding Affinities of 2-Methyl-N-(1,3-Dioxoisoindolin-2-yl) Benzamide Derivatives as Potent DPP-4 Inhibitors". Research Journal of Pharmacy and Technology. 2025;18(9):4389-5. doi: 10.52711/0974-360X.2025.00629 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-9-49
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