Author(s):
Turdiyeva Zh.A., Atazhanova G.A., Ishmuratova M.Y., Samorodov A.V., Akhmetova S.B., Medeshova A.T., Shaikina S.N., Ramazanova A., Abdikalik A.B., Zholdasbayev M.E., Amirkhanova Zh.T.
Email(s):
atazhanova@qmu.kz
DOI:
10.52711/0974-360X.2026.00020 
Address:
Turdiyeva Zh.A.1, Atazhanova G.A.1*, Ishmuratova M.Y.2, Samorodov A.V.3, Akhmetova S.B.1, Medeshova A.T.1, Shaikina S.N.1, Ramazanova A.1, Abdikalik A.B.1, Zholdasbayev M.E.1, Amirkhanova Zh.T.1
1NCJSC “Karaganda Medical University”, Gogol Str. 40., 100000, Karaganda, Kazakhstan.
2NCJSC “Karaganda University named after E.A. Buketov, Universitetskaya Str 28, Block 3., 100028, Karaganda, Kazakhstan.
3Department of Pharmacology, Bashkir State Medical University, Ufa City, 450005, Russia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 1,
Year - 2026
ABSTRACT:
We have studied the chemical composition of the essential oil of Ferula songarica and the antifungal activity of the underground part of Ferula songarica growing in the vicinity of Karkaralinsk, Karaganda region. It was revealed that the main components of this oil are pinene - 32.91% and 3-octene-5-ene-2,7-dimethyl-, (E)-19.47%. As a result of a study on antifungal activity, it was found that Ferula songarica essential oil and gel based on Ferula songarica essential oil have a pronounced antifungal effect against clinical strains of yeast fungi C. albicans, C. dubliniensis and C. glabrata. The article presents the results of the development of the composition and technology of an antifungal gel based on the essential oil of Ferula songarica, growing in Central Kazakhstan. Research has been conducted to select the optimal gel base to ensure the stability and therapeutic effectiveness of the drug. The optimal formulation parameters, including the concentration of essential oil (3%), were experimentally determined, and its high antifungal activity against strains of the yeast fungi C. albicans, C. dubliniensis and C. glabrata was confirmed. The rheological properties of the gel have been investigated, and the characteristics that ensure the convenience of application and restoration of the structure after mechanical action have been identified. The developed gel production technology ensures the stability of physico-chemical properties and microbiological purity throughout the shelf life.
Cite this article:
Turdiyeva Zh.A., Atazhanova G.A., Ishmuratova M.Y., Samorodov A.V., Akhmetova S.B., Medeshova A.T., Shaikina S.N., Ramazanova A., Abdikalik A.B., Zholdasbayev M.E., Amirkhanova Zh.T.. Development of Composition and Technology of Anti-Fungal Gel with Ferula songarica Essential Oil Growing In The Territory Of Central Kazakhstan. Research Journal of Pharmacy and Technology. 2026;19(1):131-6. doi: 10.52711/0974-360X.2026.00020
Cite(Electronic):
Turdiyeva Zh.A., Atazhanova G.A., Ishmuratova M.Y., Samorodov A.V., Akhmetova S.B., Medeshova A.T., Shaikina S.N., Ramazanova A., Abdikalik A.B., Zholdasbayev M.E., Amirkhanova Zh.T.. Development of Composition and Technology of Anti-Fungal Gel with Ferula songarica Essential Oil Growing In The Territory Of Central Kazakhstan. Research Journal of Pharmacy and Technology. 2026;19(1):131-6. doi: 10.52711/0974-360X.2026.00020 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-1-20
REFERENCES:
1. Bolatchiev A.D., Baturin V. A., Bazikov I. A. Antimicrobial gel for the treatment of infected wounds, burns and trophic ulcers. 2018.
2. Lazurina L. P. et al. Study of antimicrobial activity of multicomponent gels containing new metal biocomplexes with nitrofuran derivatives. Modern High-Tech Technologies. 2006. 5: 66-67.
3. Dinmuhammedkyzy A. A., Gazizova A. A., Utemisova Z. R. Phytochemical studies of the Dzhungarian ferula (ferula soongarica L.).
4. Kamelkhanova A.M., Vorobyev A. L., Tungushpaeva A. N. Plant growth and development regulator from ferula soongarica pall . Kronos. 2020. 5(43): 9-14.
5. Zhestovskaya E. S. et al. Investigation of the component composition of medicinal plant raw materials by gas chromatography with mass spectrometric detection. Chemistry of Plant Raw Materials. 2018; 3: 149-157.
6. Kablanova D. A., Mirzadinov R. A. A., Akymbekova L. D. Ferula Kazakhstan and their national economic importance. Bulletin of Science and Education. 2020; 20-1 (98): 18-21.
7. Bukreeva T. V. and others. The component composition of alcohol extracts from the roots of ferula soongarica (apiaceae) . Plant Resources. 2016; 52(1): 151-156.
8. A.V. Pantyukhin, A.A. Arkhangelskaya et al. Development of the composition and technology of antimicrobial ointment. A.V. Sokolova-Merkuryeva, International Scientific Research Journal. 2017; 9(63).
9. Степанова, О.И. Разработка быстрорастворимых противомикробных лекарственных препаратов, содержащих твердые дисперсии: Автореф. Дис. на соискание ученой степени канд. фарм. наук / О.И. Степанова.– Москва: Изд-во Первый МГМУ им. И.М. Сеченова, 2015. – 20 с.
10. Turdiyeva Z. H. et al. Histochemical Analysis of The Aerial part of Ferula songarica growing in the Territory of the Karaganda Region (Central Kazakhstan). Research Journal of Pharmacy and Technology. 2023; 16(11): 5079-5084.
11. Sabiyeva A. et al. Histochemical analysis of aerial part of Dracocephalum ruyschiana L. and Dracocephalum nutans L. growing in the Territory of Central Kazakhstan. Research Journal of Pharmacy and Technology. 2022; 15(9): 3831-3835.
12. Sabiyeva A. et al. Anatomical study of Dracocephalum ruyschiana L. and Dracocephalum nutans L. Research Journal of Pharmacy and Technology. 2023; 16(3): 1193-1198.
13. Bazikov I. A. and others. Antimicrobial activity of liposomal gel with doxorubicin in the complex treatment of maxillofacial melanoma. Bacteriology. 2017; 2(1): 61-65.
14. Legonkova O. A. et al. The method of obtaining an antimicrobial gel. 2020.
15. Atazhanova G. et al. Component Composition and Antimicrobial Activity of Dracocephalum nutans L. Essential Oil. Research Journal of Pharmacy and Technology. 2023; 16(10) 4881-4885.
16. Levaya, Y. К., Atazhanova, G. А., Kacergius, Т., Ivasenko, S. А., Marchenko, A. B., Ishmuratova, M. Y., and Smagulov, М. К. (2024). Salvia dumetorum essential oil: GC-MS analysis, antibacterial activity and effect on the formation of Streptococcus mutans biofilms. Natural Product Research, 38(20), 3555–3561. https://doi.org/10.1080/14786419.2023.2256019
17. Badekova K. et al. Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice. Journal of Toxicology. 2023; 1: 6691-694.
18. Atazhanova, G. A., Badekova, K. Z., Ivasenko, S. A., Kacergius, T., Levaya, Y. K., Kurmantaeva, G. K. amd Smagulov, M. K. Influence of essential oils on the formation of Streptococcus mutans biofilms. Research Journal of Pharmacy and Technology. 2022; 15(11): 4959-4966.
19. Badekova, K. Z., Atazhanova, G. A., Ishmuratova, M. Y., Akhmetova, S. B., Brazhanova, A. K., amd Tazhina, A. M. Morpho-Anatomical study of Origanum vulgare L. Growing in the Akmola Region of Kazakhstan. Research Journal of Pharmacy and Technology. 2024; 17(7): 3013-3018.
20. Itzhanova K. I. et al. Technology of Application Dosage Form with Extract of Xanthium strumarium L. for use in Dental Practice. Research Journal of Pharmacy and Technology. 2024; 17(11): 5561-5566.
21. Medeshova A. et al. Development of Composition and Technology of suppositories based on substance from medicinal plant raw materials Rosmarinus officinalis L. Research Journal of Pharmacy and Technology. 2024; 17(11): 5452-5456.
22. Medeshova A. et al. Development and Rheological studies of gels with Essential oil of Chamomile (Chamomillae recutita L.) //Research Journal of Pharmacy and Technology. 2023; 16(11) 5161-5166.
23. Kirillov V, Pathak A, Zholdasbayev M, Atazhanova G, Sapiyeva A, Stikhareva T, Serafimovich M, Daulenova M. HPLC and GC/MS analysis of Prunus ulmifolia Franch. (syn. Aflatunia ulmifolia (Franch.) Vassilcz.) leaves growing in South-Eastern Kazakhstan. Nat Prod Res. 2022 Oct 27: 1-9.
24. Badekova K.Zh., Aitkenova A.A., Atayeva A.K. Database of Ethereal Oil Plants and Essential Oils of Kazakhstan. Medicine and ecology. 2020; 2: 78-81.
25. Kurmantayeva G. K. et al. Morphological and Anatomical Study of Aerial organs of Nepeta pannonica L. Research Journal of Pharmacy and Technology. 2024; 17(11): 5311-5316.
26. Akhmediya R.E., Ikhambayeva A.N., Akhmadyar N.S., Koshayeva Sh.K., Bikhert M.E. Non-steroid anti-inflammatory drugs: recommendations and precautions for safe use in a multidisciplinary surgical department. Medicine and Ecology. 2024; (3): 105-112. (In Russ.) https://doi.org/10.59598/ME-2305-6045-2024-112-3-105-112