Author(s):
Archana S. Patil, Siddharth S. Vernekar, Yadishma Gaude, Sunil Gurav, Gandla Kumaraswamy
Email(s):
archanapatil@klepharm.edu
DOI:
10.52711/0974-360X.2026.00660 
Address:
Archana S. Patil1*, Siddharth S. Vernekar1, Yadishma Gaude1, Sunil Gurav1, Gandla Kumaraswamy2
1Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
2Department of Pharmaceutical Analysis, Chaitanya Deemed to be University, Hanamakonda, Telangana - 506001, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
The objective of the present study was to develop and evaluate a simple and reliable UV-spectrophotometric method for the quantification of Cabotegravir, an antiretroviral drug. Cabotegravir exhibited maximum absorbance at 257 nm using methanol as the solvent, with a linear concentration range of 2–12 µg/ml. The proposed method was optimized and validated in accordance with ICH guidelines for parameters including linearity and range, robustness, specificity, sensitivity, ruggedness, and precision, with all results meeting the acceptance criteria. The method demonstrated excellent specificity, selectivity, linearity, precision, robustness, and repeatability, with percent RSD values below 2%. This novel analytical approach is straightforward, reproducible, and reliable, making it suitable for routine quality control analysis of pure Cabotegravir and its pharmaceutical formulations in the industry.
Cite this article:
Archana S. Patil, Siddharth S. Vernekar, Yadishma Gaude, Sunil Gurav, Gandla Kumaraswamy. Development and Validation of a UV-Spectrophotometric Method for the Quantification of Cabotegravir. Research Journal Pharmacy and Technology. 2026;19(10):4736-0. doi: 10.52711/0974-360X.2026.00660
Cite(Electronic):
Archana S. Patil, Siddharth S. Vernekar, Yadishma Gaude, Sunil Gurav, Gandla Kumaraswamy. Development and Validation of a UV-Spectrophotometric Method for the Quantification of Cabotegravir. Research Journal Pharmacy and Technology. 2026;19(10):4736-0. doi: 10.52711/0974-360X.2026.00660 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-10-36
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