Author(s): Elmira Kabdylkanova, Dinara Satmbekova, Moldir Koilybayeva, Elmira Kartbayeva, Lazzat Sarsenova, Bakhyt Iskakova, Bekbolat Baltabay

Email(s): elmirakabdylkanova94@gmail.com , ORCID:https://orcid.org/0000-0002-3203-282X , satmbekova.dinara@med-kaznu.com , ORCID:https://orcid.org/0000-0003-1087-3932 , koilybayeva.mk@gmail.com , ORCID:https://orcid.org/0000-0002-8401-9977 , e.kartbayeva@gmail.com , ORCID:https://orcid.org/0000-0003-0135-5818 , Lazzat.Sarsenova@kaznu.edu.kz , ORCID:https://orcid.org/0000-0001-8643-0703 , iskakova.bakhit@kaznmu.kz , ORCID:https://orcid.org/0009-0006-1769-1735 , bekbolatnis@gmail.com

DOI: 10.52711/0974-360X.2026.00690   

Address: Elmira Kabdylkanova1, Dinara Satmbekova1*, Moldir Koilybayeva2, Elmira Kartbayeva1, Lazzat Sarsenova1, Bakhyt Iskakova3, Bekbolat Baltabay4
1Al-Farabi Kazakh National University, Department of Medicine and Healthcare, Almaty, Kazakhstan.
2Asfendiyarov Kazakh National Medical University, Department of Pharmaceutical Technology, Almaty, Kazakhstan.
3Asfendiyarov Kazakh National Medical University, Department of Psychiatry and Narcology, Almaty, Kazakhstan.
4LLP “Pharm Consult Group”, Almaty, Kazakhstan.
*Corresponding Author

Published In:   Volume - 19,      Issue - 10,     Year - 2026


ABSTRACT:
Medicinal plants remain instrumental in healthcare due to their abundance of bioactive compounds. Endemic species, in particular, require targeted research, as many remain understudied despite evidence of their biological potential. Numerous anticancer drugs are derived from plants, highlighting the importance of studying underrepresented flora. The unique botanical diversity of Kazakhstan includes Eminium regelii, a rare endemic species of the Araceae family. Although experimental data are limited, early in vitro studies indicate potential anticancer properties. Phytochemical analysis identified luteolin and quercetin as active components. Unlike other species in this genus, E. regelii remains understudied, highlighting the need for further phytochemical and pharmacological research. Furthermore, nanodelivery systems offer a promising strategy for enhancing the solubility, absorption, and efficacy of these flavonoids in future studies. The aim of this review is to comprehensively analyze the therapeutic potential of Eminium regelii as a promising anticancer agent based on existing data.


Cite this article:
Elmira Kabdylkanova, Dinara Satmbekova, Moldir Koilybayeva, Elmira Kartbayeva, Lazzat Sarsenova, Bakhyt Iskakova, Bekbolat Baltabay. Endemic Plants of Kazakhstan: Emphasis on Eminium Regelii and its Anticancer Potential: A Review. Research Journal Pharmacy and Technology. 2026;19(10):4955-2. doi: 10.52711/0974-360X.2026.00690

Cite(Electronic):
Elmira Kabdylkanova, Dinara Satmbekova, Moldir Koilybayeva, Elmira Kartbayeva, Lazzat Sarsenova, Bakhyt Iskakova, Bekbolat Baltabay. Endemic Plants of Kazakhstan: Emphasis on Eminium Regelii and its Anticancer Potential: A Review. Research Journal Pharmacy and Technology. 2026;19(10):4955-2. doi: 10.52711/0974-360X.2026.00690   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-10-66


REFERENCES:
1.    Pankaj B et al. A Systematic Review on Anticancer Phytosomal Flavonoids. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(4): 343-6. doi: 10.52711/2231-5659.2023.00059 
2.    Manthan R et.al. Herbal Healer: A Comprehensive Review of the Overall Plant Profile and Medicinal Properties of Glycyrrhiza glabra. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(3): 299-3. doi: 10.52711/2231-5659.2024.00048
3.    Salykova A et al. Methodological guide for geobotanical research on rare, endemic, and medicinal plants: a case study of the Ranunculaceae family. ES Food Agrofor. 2024; https://doi.org/10.30919/esfaf1340
4.    Mat Jusoh MAA et al. A review of Malaysian medicinal plants with potential anticancer activity. Malays. Appl. Biol. 2023; 52(1): 1–34.https://doi.org/10.55230/mabjournal.v52i1.2274
5.    Adetunji TL et al. Global research trends and recent advances in medicinal plant-synthesized nanoparticles for cancer treatment. 2024; 13(20): 2836..https://doi.org/10.3390/plants13202836 
6.    Panyajai P et al.  Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG‑1a leukemic stem cells. BMC Complement. Med. Ther. 2025; 25(1): 87. https://doi.org/10.1186/s12906-025-04321-6 
7.    Abroudi M et al. Antiproliferative effects of Ferula assa-foetida's extract on PC12 and MCF7 cancer cells. Int J Biomed Eng Clin Sci.2020;6(3): 60–64. https://doi.org/10.11648/j.ijbecs.20200603.12 
8.    Ghadge D et al.. Design and Development of Solid Self-Microemulsifying Drug Delivery of Gefitinib. Asian J. Pharm. Tech. 2018; 8 (4): 193-199. doi:10.5958/2231-5713.2018.00031.4 
9.    Aumeeruddy MZ, Mahomoodally MF Global documentation of traditionally used medicinal plants in cancer management: A systematic review. S. Afr. J. Bot. 2021; 138: 424–494.https://doi.org/10.1016/j.sajb.2021.01.006
10.    Intarasam S et al. Cell viability enhancing and cellular protection activity of Vitex glabrata R.Br. crude fruits extract on TK6 and L929 cell lines. Thai J. Pharm. Sci. 2020; 44(4): 220–228. https://www.thaiscience.info/Journals/Article/TJPS/10996252.pdf
11.    Guo W et al. 2022 Medicinal plants for the treatment of gastrointestinal cancers from the metabolomics perspective. Front. Pharmacol. 2022; 13: 909755. https://doi.org/10.3389/fphar.2022.909755 
12.    Wang CZ et al. American ginseng attenuates colitis-associated colon carcinogenesis in mice: impact on gut microbiota and metabolomics. Cancer Prev. Res. 2016;9: 803–811. https://doi.org/10.1158/1940-6207.CAPR-15-0372
13.    Huang J et al. Integrating network pharmacology and experimental models to investigate the efficacy of Coptidis and Scutellaria containing Huanglian Jiedu decoction on hepatocellular carcinoma. Am. J. Chin. Med. 2020; 48: 161–182. https://doi.org/10.1142/S0192415X20500093 
14.    Dallavalle S et al.  Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors. Drug Resist. Updat. 2020; 50: 100682. https://doi.org/10.1016/j.drup.2020.100682 
15.    Garcia-Oliveira P et al. Status and challenges of plant-anticancer compounds in cancer treatment. Pharmaceuticals. 2021; 14(2): 157. https://doi.org/10.3390/ph14020157 
16.    Cech NB, Oberlies NH From plant to cancer drug: lessons learned from the discovery of taxol. Nat. Prod. Rep. 2023; 40(7): 1153–1157. https://doi.org/10.1039/D3NP00017F     
17.    Ohiagu FO et al. Anticancer activity of Nigerian medicinal plants: a review. Future J. Pharm. Sci. 2021; 7: 70. https://doi.org/10.1186/s43094-021-00222-6 
18.    Grudzinskaya LM et al. The Kazakhstan medicinal flora survey in leading families. Bulletin of Karaganda University. Biology. Medicine. Geography Series. 2020; 4(100): 39–51.https://doi.org/10.31489/2020bmg4/39-51
19.    Kubentayev SA et al. Revised checklist of endemic vascular plants of Kazakhstan. PhytoKeys. 2024; 238: 241–279. https://doi.org/10.3897/phytokeys.238.114475 
20.    Nendissa DR et al. Sustainable livestock grazing in Kazakhstan: practices, challenges, and environmental considerations. Casp. J. Environ. Sci. 2023; 21(4): 977–988. http://dx.doi.org/10.22124/CJES.2023.7156 
21.    Qaseem MF et al. Ethnobotanical evaluation of traditional medicinal plants among three rural communities of Goi and Dhanwa union council, District Kotli, Azad Jammu and Kashmir. Appl. Ecol. Environ. Res. 2019;16(2): 340–349.
22.    Mukasheva T Ethnobotanical survey of medicinal plant use in rural Kazakhstan.  J. Ethnopharmacol. 2021; 278: 114–23
23.    Pavlov NV (ed.).Flora Kazakhstana [Flora of Kazakhstan], Vol. 2. Izdatelstvo Akademii nauk Kazakhskoi SSR, Alma-Ata. 1958. p. 85. [In Russian]
24.    Sinitsin GS. Eminium Regelya – novoe lekarstvennoe rastenie Kazakhstana [Eminium regelii – a new medicinal plant of Kazakhstan]. Izvestiya Akademii Nauk KazSSR.1982; (2): 21–4. [In Russian]
25.    Pavlov NV (Ed.) Flora Kazakhstana [Flora of Kazakhstan], Vol. 2. Izdatelstvo Akademii Nauk KazSSR, Alma-Ata. 1961. p. 85.[In Russian]
26.    Abylaeva BA et al. Growing cell cultures of some rare local species of medicinal plants. BIO Web of Conferences. 2023 76: 03001. https://doi.org/10.1051/bioconf/20237603001
27.    Kazflora. Eminium regelii (Regel) Engl. [Internet]. Almaty: Kazflora; [cited 2025 Jul 24]. Available from: https://kazflora.kz/catalog/?ELEMENT_ID=208252
28.    Kutpanbaev SM. Kazakhstanda osetin taualg’y men kushala osimdikterinin’ keibіr bіologiyalyq er’ekshelіkterі [Some biological features of Delphinium and Aconitum species growing in Kazakhstan]. Vestnik Akademii Nauk KazSSR.1961.(2):83–7. [In Kazakh]
29.    Zharykbassova KS ey al. Rasprostranenie Eminiuma Regelia v Karatauskom gosudarstvennom zapovednike [Distribution of Eminium regelii in the Karatau State Nature Reserve]. Novosti nauki Kazakhstana. 2014; (3):107–119. [In Russian]
30.    Kukenov MK. Botanicheskoe resursosvedenie Kazakhstana [Botanical resource science of Kazakhstan].Gylym, Almaty. 1999.160 p. ISBN: 5-628-02497-X.[In Russian]
31.    Affifi FU, Abu-Dahab R Phytochemical screening and biological activities of Eminium spiculatum (Blume) Kuntze (family Araceae). Nat Prod Res 2012; 26(9): 878–882. 10.1080/14786419.2011.565558 
32.    Zharykbassova KS et al. Issledovanie i razrabotka tekhnologii kumysa, obladayushchego vysokimi immunomoduliruyushchimi svoystvami [Research and development of kumys technology with high immunomodulatory properties]. Novosti nauki Kazakhstana. 2015; (1):78–87. [In Russian]
33.    Sezik E et al. Folk medicine in Uzbekistan: I. Toshkent, Djizzax, and Samarqand provinces. J. Ethnopharmacol. 2004; 92(2–3):197–207. https://doi.org/10.1016/j.jep.2004.02.016 
34.    Zhetpisbayev BA et al.  Effectiveness of the influence of Eminium regelii extract on lipid peroxidation and antioxidant defense in central immunogenesis organs under combined exposure to fractional doses of gamma radiation and emotional stress  Medicine and  Ecology (Kazakhstan). 2018;(4): 111–120. [In Russian] https://medecol.qmu.kz/jour/article/view/86?locale=ru_RU 
35.    Gomathy S et al. Liquid chromatography-mass spectrometric method for simultaneous estimation of apigenin and luteolin from Achillea millefolium Linn. Asian J. Research Chem. 2016; 9(12): 629-632. doi: 10.5958/0974-4150.2016.00086.9
36.    Asgharian P et al. Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets. Cancer Cell Int. 2022; 22(1): 257. https://doi.org/10.1186/s12935-022-02677-w 
37.    Sandip GB et al. A Comprehensive Review on the Moringa oleifera. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(1): 87-1. doi: 10.52711/2231-5659.2025.00013
38.    Batiha GE et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020; 9(3): 374. https://doi.org/10.3390/foods9030374 
39.    K. Prasada Rao et al. Characterization and Antimicrobial activity of Some Flavones. Asian J. Research Chem. 6(2): February 2013; Page 163-165.
40.    Sushil DP et.al. Docking Studies and Synthesis of Novel Flavones Screened for Biological Activities like Anticancer and Antioxidant Activity. Asian J. Research Chem. 2015; 8(6): 399-406. doi: 10.5958/0974-4150.2015.00066.8
41.    Akshay R. Yadav, Shrinivas K. Mohite. Anticancer Activity of Psidium guajava Leaf Extracts on Breast Cancer Cell Line. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 298-300. doi: 10.5958/0975-4377.2020.00049.X
42.    Reenu Joseph et al. Anticancer effect of sequential extracts from Curcuma caesia rhizomes on human cancer cell lines and characterization of selected polyphenols in active extracts by LC-MS/MS. Asian Journal of Pharmaceutical Research. 2023; 13(4): 219-6. doi: 10.52711/2231-5691.2023.00041
43.    Singh A et al. Harnessing luteolin’s therapeutic potential in human disorders: medicinal significance, biological, clinical properties and analytical aspects. Pharmacol. Res. Mod. Chin. Med. 2024; 10:100401. https://doi.org/10.1016/j.prmcm.2024.100401 
44.    Rauf A, Wilairatana P, Joshi PB, Ahmad Z, Olatunde A, Hafeez N, Hemeg HA, Mubarak MS (2024) Revisiting luteolin: An updated review on its anticancer potential. Heliyon 10(5): e26701. https://doi.org/10.1016/j.heliyon.2024.e26701
45.    Xu J et al. Virtual screening and experimental validation of luteolin cocrystals for enhanced solubility. J. Mol. Struct. 2025; 1337: 142207. https://doi.org/10.1016/j.molstruc.2025.142207  
46.    Shang J et al. Nano-scale drug delivery systems for luteolin: advancements and applications. J. Mater. Chem. B. 2023;11: 11198–11216. https://doi.org/10.1039/D3TB01753B 
47.    Raksha B et al. Nanoencapsulation of luteolin: enhancing bioavailability and medicinal benefits. International Journal of Pharm. Pharm. Sci. 2023; 15: 1–12. https://doi.org/10.22159/ijpps.2023v15i12.49440
48.    Athar J, Ayesha M. Review of Synthesis of Silver Nanoparticles from different Medicinal Plants and their Pharmacological Activities. Asian J. Pharm. Tech. 2021; 11(1): 88-93. doi: 10.5958/2231-5713.2021.00015.5 
49.    Majumdar D et al. Luteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activity. Cancer Prev. Res. 2014; 7(1): 65–73. https://doi.org/10.1158/1940-6207.CAPR-13-0230
50.    Babacan EY et al. Orbitrap Mass Spectrometry-Based Profiling of Secondary Metabolites in Two Unexplored Eminium Species and Bioactivity Potential. Plants 2023; 12(12), 2252. https://doi.org/10.3390/plants12122252 
51.    Khalid M et al. Evaluating the antioxidant, antimicrobial, and anticancer effects of Eminium spiculatum plant extracts. Nat. Prod. Commun. 2024; 19(11): 1934578X241299230. https://doi.org/10.1177/1934578X241299230 
52.    Asma ST et al. Natural products/bioactive compounds as a source of anticancer drugs. Cancers 2022; 14(24): 6203. https://doi.org/10.3390/cancers14246203
53.    Bown D. Aroids: Plants of the Arum Family. Timber Press, Portland (OR).2000; 2nd ed:  pp.392. ISBN: 0881924857 
54.    Han M et al. Phytochemical study of the rhizome of Pinellia ternata and quantification of phenylpropanoids in commercial Pinellia tuber by RP-LC. Chromatographia. 2006; 64: 647–653. doi.org/10.1365/s10337-006-0103-8
55.    Meher RK et al. Analysis of anti‑cancer and anti‑inflammatory activity in Typhonium flagelliforme rhizome extract by induction of apoptosis: An in‑vitro study. Fitoterapia. 2025 182: 106470. https://doi.org/10.1016/j.fitote.2025.106470 
56.    Rekha S, Anila EI  In vitro cytotoxicity studies of surface-modified CaS nanoparticles on L929 cell lines using MTT assay. Mater. Lett. 2019; 236: 637–639. https://doi.org/10.1016/j.matlet.2018.11.009 
57.    Canga I et al. In vitro cytotoxic activity of African plants: a review. Molecules.2022; 27(15): 4989. https://doi.org/10.3390/molecules27154989 



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